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VHIO/Weizmann Institute of Science Joint Conference on Cell Communication in Translational Research, 22 – 23 January, 2015, Rehovot, Israel

Sponsors:

Please note: this is VHIO´s landing page for the forthcoming joint Weizmann Institute of Science – Vall d´Hebron Institute of Oncology Conference on Cell Communication in Translational Research, 22 – 23 January 2015, Rehovot, Israel. To visit the offical WIS-VHIO joint conference page please visit: http://wws.weizmann.ac.il/conferences/CCTR2015/

Conference Synopsis from the Co-Chairs

Cell communication is essential for life. Carried out in various ways, including through electromagnetic, chemical, and sensory signals, cellular communication underlies the development and activity of every cell. It is just beginning to be understood. However, what is well known is that cell communication can break down, resulting in various diseases and can also devolve into uncontrolled cell growth, often leading to cancer. Cancer can occur in many ways, but it always requires multiple signaling breakdowns. Often, cancer begins when a cell gains the ability to grow and divide even in the absence of a signal. Ordinarily this unregulated growth triggers a signal for self-destruction. But when the cell also loses the ability to respond to death signals, it divides out of control, forming a tumor. Later, cell communication events cause blood vessels to grow into the tumor, enabling it to grow larger. Additional signals allow the cancer to spread to other parts of the body. In cancer, the cellular communication systems provide potential targets for therapeutic intervention by “intercepting” signals and inhibiting the growth of tumors.

Basic research in biomedical sciences involves elucidating the mechanisms that drive diseases; clinical research addresses the complexity inherent in disease states, which is key to identifying the targets for pharmacological intervention. A combination of both these distinct approaches is needed for understanding human diseases, the majority of which are by nature multi-faceted and evolve over time. Translational research embodies such an amalgamation, by which lab science is translated to the intricacy of the ‘real’ world.

The goal of our VHIO/Weizmann Institute of Science Joint Conference on Cell Communication in Translational Research, 22 – 23 January, 2015, Rehovot, Israel, is to bring together researchers of these two intellectual powerhouses, as well as scientists from other institutions of excellence, in order to provide a platform for continuing dialogue and to subsequently launch productive collaborations addressing the questions and problems at the heart of the battle against cancer.

We look forward to warmly welcoming you all for this must-have conversation into the breakdown of cell communication, the consequential cancer growth and spread, and promising new therapeutic avenues against it.

Symposium Co-Chairs:

Scientific Program

Commencing with a welcome dinner on the evening of Wednesday, 21st January 2015 at the Weizmann Institute of Science, the official scientific program will run across one and a half days from Thursday 22nd January, 08:00 – 20:30h, including dinner following directly after the final session of the day, to Friday 23rd January, 08:30 – 12:30, with an optional informal, social opportunity thereafter to further enjoy the company of both speakers and participants alike.

Incorporating an outstanding panel of speakers, specially selected from among WIS and VHIO Faculty as well as other leading research institutes from Spain, the scientific program will be engineered to report on pioneering research into cancer molecular mechanisms and dedicated efforts towards precision cancer science and medicine:

22nd JANUARY 2015

08:00 - 08:45 Registration & Coffee

08:45 - 09:00 Welcome from the Co-Chairs Joaquín Arribas and Irit Sagi

09:00 - 10:25 SESSION I

09:00 - 09:35

Keynote: Yossi Yarden, Principal Investigator, Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel: It takes two to tango: HER2 and EGFR in cancer progression and therapy

09:35 - 10:00

Joaquín Arribas, ICREA Research Professor, Director of Preclinical Research, Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Spain: Targeting intercellular communication during breast cancer progression

10:00 - 10:25

Valery Krizhanovsky, Assistant Professor, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel: Senescent cells communicate via intercellular protein transfer

10:25 - 10:45 Coffee Break

10:50 - 12:30 SESSION II

10:50 - 11:15

Héctor G. Palmer, Principal Investigator, Stem Cells & Cancer Group,Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Spain: New molecular insights in colorectal cancer metastasis and treatment

11:15 - 11:40

Irit Sagi, Principal Investigator, Department of Biological RegulationDean, Feinberg Graduate School, Weizmann Institute of Science, Rehovot, Israel: Cell-Communication combinatorial programs contributing to formation of cancer metastasis niche

11:40 - 12:05

Alicia Arroyo, Group Leader, Matrix Metalloproeinases in Angiogenesiand Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain: MT-MMPs: multi- faceted proteases in angiogenesis and inflammatory disease

12:05 - 12:30

Michal Neeman, Principal Investigator, Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel: Tumor-Stroma communication in ovarian carcinoma

12:30 - 13:30 Lunch

13:30 - 15:10 SESSION III

13:30 - 13:55

Ravid Straussman, Assistant Professor, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel: The effects of crosstalk in the tumor microenvironment on chemoresistance

13:55 - 14:20

Joan Seoane, ICREA Research Professor, Director of Translational Research, Vall d´Hebron Institute of Oncology (VHIO), Barcelona Spain: Intratumor heterogeneity in brain tumors

14:20 - 14:45

Yardena Samuels, Principal Investigator, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel: The genetics of melanoma: searching for new therapeutic targets

14:45 - 15:10

Berta Strulovici, Head of The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot, Israel:Enabling basic and clinical research with novel technology platforms

15:10 - 15:40 Coffee Break

15:40 - 17:00 SESSION IV

Selected talks, chosen out of abstract submitters:

15:40 – 15:55

Jonathan Whitfield, Staff Scientist, Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain: Preclinical validation of Myc inhibition by a new generation of Omomyc-based inhibitors

16:00 – 16:20

Kim Pedersen, Post-Doctoral Fellow, Growth Factors Group, Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Spain: Pancreatic cancer heterogeneity and response to anti-MEK therapy

16:20 – 16:40

Dalit Barkan, Haifa University, Haifa, Israel: Integrin alpha V beta 3 expression in luminal breast cancer cells promotes their reversion to acinar-like structure in conjunction with their relevant microenvironment

16:40 – 17:00

Filip Bochner, Weizmann Institute of Science, Rehovot, Israel: A Novel Intravital Imaging Window for Longitudinal Microscopy of Mouse Ovary

17:00 - 18:25 Poster session and Student Flash Talks

18:25 - 20:25 Dinner

23rd JANUARY 2015

08:00 - 08:30 Gathering & Coffee

08:30 - 09:55 SESSION V

08:30 - 09:05

Keynote: Josep Tabernero, Director and Director of Clinical Research, Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Spain: Dissecting Colorectal Cancer in Multiple Targetable Subtypes

09:05 - 09:30

Diego Arango, Principal Investigator, CIBBIM – Nanomedicine Molecular Oncology, Vall d´Hebron Research Institute (VHIR), Barcelona Spain: RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

09:30 - 09:55

Mosche Oren, Principal Investigator, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel: p53 in the cross-talk between tumor and stroma

09:55 - 10:20 Coffee Break

10:20 - 11:50 SESSION VI

10:20 - 10:45 

Idit Shachar, Weizmann Institute of Science, Rehovot, Israel: The molecular mechanism regulating the cross-talk between CLL cells and their microenvironment

10:45 - 11:25

Selected abstract talks:

10:45 - 11:00

Adi Sagiv, Weizmann Institute of Science, Rehovot, Israel: Mechanisms of Communciation between Senescent cells and NK cells

11:00 - 11:25

Oriol Arqués, Graduate Student, Stem Cells & Cancer Group, Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Spain: Tankyrase inhibition blocks Wnt/b-catenin pathway and reverts resistance to PI3K and AKT inhibitors in the treatment of colorectal cancer

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11:25 - 11:50

Avigdor Scherz, Weizmann Institute of Science, Rehovot, Israel: Regressing cancer dissemination by local therapy and immune modulation - from bench to clinic

11:50 - 12:30 Closing Remarks: Joaquín Arribas and Irit Sagi

12:30             Trip to Jerusalem

13:30             Guided waling tour (in English) of Jerusalem

18:00             Expected arrival back at hotel in Rehovot

Abstract Submission & Registration

Abstract Submission and Registration are now closed. 

Contact

For any queries or questions please contact Amanda Wren directly: awren@vhio.net, Tel. +34 934893021, Mobile: +34 69520788.