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PRINCIPAL INVESTIGATORS

SANDRA PEIRÓ

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SANDRA PEIRÓ

Current positions

Academic Qualifications

  • PhD in Biochemistry, Barcelona University, Spain
  • BSc in Biochemistry, Barcelona University, Spain

Areas of Research

  • Biology and Biochemistry, chromatin structure, transcription regulation, epigenetics.

Prizes and Scholarships

  • 2015-Guest Professor, First CRG Course: The 3D structure of the genome: technical and computational approaches from 3C to Hi-C, CRG, Barcelona.
  • 2014-Awarded a Miguel Servet Contract II from the Spanish Ministry of Health.
  • 2013-Accreditation of Research, Agencia Catalana de Acreditació I Certificació.
  • 2013-Awarded Betty Hay Award TEMTIA for contributions to the field as a young female scientist who has established her laboratory within the last 5 years.
  • 2012-Assistant Professor, Faculty of Human Biology, Universitat Pompeu Fabra, Barcelona.
  • 2011–2015-Guest Professor, Genes & Function Course, Universitat Pompeu Fabra, Barcelona.
  • 2010-Assistant Professor, Faculty of Human Biology, Universitat Pompeu Fabra, Barcelona.
  • 2009-Awarded a Miguel Servet Contract from the Spanish Ministry of Health; selected from more than 250 applications.
  • 2007-Assistant Professor credentials, Agencia Catalana de Acreditació I Certificació.
  • 2005-Eukaryotic Gene Expression Course. One of 15 selected students from 50 international applicants. Cold Spring Harbor Laboratory, USA.
  • 2004-Awarded a Juan de la Cierva contract from the Spanish Ministry of Science and Innovation; selected from more than 250 applications
  • 2004-Awarded an AECC Investigator contract.
  • 1998–2001 Assistant Professor, Faculty of Medicine, Barcelona University, Barcelona.
  • 1996-First Award, Catalan Biology Society, Barcelona.

Most relevant scientific publications

  • Herranz N, Dave N, Millanes-Romero A, Pascual L, Morey L, Díaz VM, Lorenz-Fonfria V, Gutierrez-Gallego R, Jerónimo C, Itubide A, Di Croce L, García de Herreros A and Peiró S. Lysyl Oxidase-Like 2 (LOXL2) Oxidizes Trimethylated Lysine 4 in Histone H3. FEBS J. 2016
  • Itubide A, Pascual L, Fargas L, Cebrià JP, Alsina B, García de Herreros A and Peiró S. LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation. Mol Cell. 2015
  • Millanes-Romero A, Herranz  N,  Loubat  J,  Iturbide  A,  Perrera  V,  Gil  J,  Jenuwein  T,  García  de Herreros A and Peiró S. Regulation of Heterochromatin Transcription by Snail1/ LOXL2 During Epithelial to Mesenchymal Transition. Mol Cell. 2013.
  • Herranz N, Pasini D, Díaz V, Francí C, Gutierrez  A, Dave N, Escrivà M, Hernandez-Muñoz  I, di Croce  L,  Helin  K,  García  de  Herreros  A  and  Peiró  S.  Polycomb complex 2 is required for E- Cadherin repression by Snail1 transcription factor. Mol Cell Biol. 28: 47772-81. 2008. 
  • Escrivà M*, Peiró S* (co-authors),  Herranz N, Villagrasa P, Dave N, Montserrat-Sentís  B, Murray SA, Francí C, Gridley T, Virtanen I and García de Herreros A. Repression of PTEN phosphatase by Snail1  transcriptional  factor  during  gamma  radiation-induced  apoptosis. Mol Cell Biol. 28: 1528-40. 2008.

All publications

  • Herranz N, Dave N, Millanes-Romero A, Pascual L, Morey L, Díaz VM, Lorenz-Fonfria V, Gutierrez-Gallego R, Jerónimo C, Itubide A, Di Croce L, García de Herreros A and Peiró S. Lysyl Oxidase-Like 2 (LOXL2) Oxidizes Trimethylated Lysine 4 in Histone H3. FEBS J. 2016
  • Frigola J, Iturbide A, Lopez-Bigas N, Peiró S and Gonzalez-Pérez A. Altered oncomodules underline chromatin regulatory factors driver mutations. Oncotarget.  2016.
  • Beltran M, Aparicio-Prat E, Mazzolini R, Millanes-Romero A, Massó P, Jenner R, Díaz V, Peiró S and Garcia de Herreros A. Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucl Acids Res. 2015
  • Itubide A, Pascual L, Fargas L, Cebrià JP, Alsina B, García de Herreros A and Peiró S. LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation. Mol Cell. 2015
  • Itubide A, García de Herreros A and Peiró S. A new role for LOX and LOXL2 proteins in transcription regulation. FEBS Lett. Upcoming Special Issue: Epigenetics. 2014
  • Cebrià JP, Millanes-Romero A, García de Herreros A and Peiró S. The Essential Role of Heterochromatin Transcription in Cellular Transitions: The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case. Mol Cell Oncol. 2014.
  • Millanes-Romero A, Herranz  N,  Loubat  J,  Iturbide  A,  Perrera  V,  Gil  J,  Jenuwein  T, García  de Herreros A and Peiró S. Regulation of Heterochromatin Transcription by Snail1/ LOXL2 During Epithelial to Mesenchymal Transition. Mol Cell. 2013.
  • Villagrasa P, Díaz VM, Viñas-Castells R, Peiró S, Del Valle-Pérez B, Dave N, Rodríguez-Asiain  A, Casal JI, Lizcano JM, Duñach M, García de Herreros A. Akt2 interacts with Snail1 in the E-Cadherin promoter. Oncogene. 2011.
  • Dave N, Guaita-Esteruelas  S, Gutarra S, Frias À, Beltran M, Peiró S, de Herreros AG. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem. 2011.
  • Garcia  de  Herreros  A,  Peiró  S,  Nassour  M,  Savagner  P.  Snail  family  regulation  and  epithelial mesenchymal transitions in breast cancer progression. J. Mammary Gland Biol Neoplasia. 2010.
  • Herranz N, Pasini D, Díaz V, Francí C, Gutierrez  A, Dave N, Escrivà M, Hernandez-Muñoz  I, di Croce  L,  Helin  K,  García  de  Herreros  A  and  Peiró  S.  Polycomb  complex  2  is  required  for  E- Cadherin repression by Snail1 transcription  factor. Mol Cell Biol. 28: 47772-81. 2008. 
  • Escrivà M*, Peiró S* (co-authors),  Herranz N, Villagrasa P, Dave N, Montserrat-Sentís  B, Murray SA, Francí C, Gridley T, Virtanen I and García de Herreros A. Repression of PTEN phosphatase by Snail1  transcriptional  factor  during  gamma  radiation-induced  apoptosis. Mol Cell Biol. 28: 1528-40. 2008.
  • Mejias-Luque  R,  Peiró  S,  Vincent  A,  Van  Seuningen  I  and  de  Bolós  C.  IL-6  induces  MUC4 expression  through  go130/STAT3   pathway  in  gastric  cancer  cell  lines.  BBA  Mol Cell Res. 10: 1728-36. 2008.
  • Solanes G, Porta de la Riva M, Agustí C, Casagolda  D, Sanchez-Aguilera  F, Larriba MJ, Pons F, Peiró S, Escrivà M, Muñoz A, Duñach M, García de Herreros A and Baulida J. E-Cadherin controls b-catenin  and  NFkB  transcriptional  activity  in  mesenchymal  gene  expression. J Cell Sci. 121: 2224-34. 2008.
  • Wanami  L, Chen  H, Peiró  S, García  de Herreros  A and Bacheler R. Vascular  endothelial  growth factor-A stimulates Snail expression in breast tumor cells: Implications for tumor progression. Exp Cell Res. 13: 2448-53. 2008.
  • Ortiz-Zapater  E*, Peiró S* (co-authors),  Roda O, Coromines  JM, Aguilar S, Ampurdanes C, Real FX  and  Navarro  P. Tissue  plasminogen  activator  induces  pancreatic  cell proliferation  by  a non- catalytic mechanism that requires ERK1/2 activation through Epidermal Growth Factor receptor and Annexin A2. Am J Pathol. 170: 1573-84. 2007.
  • Peiró S, Escrivà M, Puig I, Barberà MJ, Dave N, Herranz N, Larriba MJ, Takkunen M, Francí C, Muñoz A, Virtanen I, Baulida J and García de Herreros A. Snail1 transcriptional  repressor binds to its own promoter and controls its expression. Nucl Acids Res. 34: 2077-84. 2006.
  • Palmer HG, Larriba MJ, Garicia JM, Ordoñez-Moran  P, Pena C, Peiró S, Puig I, Rodriguez De la Fuente  R, Bernad  A, Pollan  M, Bonilla  F, Gamallo  C, García  de Herreros  A and Muñoz  A. The transcription  factor  Snail1  represses  vitamin  D receptor expression  and responsiveness  in human colon cáncer. Nat Med. 10: 917-19. 2004.
  • Barberà MJ, Dominguez D, Puig I, Julien-Grille S, Guaita S, Baulida J, Francí C, Peiró S, Deehar S, Laure L and García de Herreros A. Regulation of Snail transcription during epitelial to mesenchymal transition of tumor cells. Oncogene. 23: 7345-54. 2004.
  • Iularu M, Demontis F, Corada M, Zanetta L, Drake C, Gariboldi M, Peiró S, Cano A, Navarro P, Cattelino A, Tognin S, Marchisio PC and Dejana E. VE-Cadherin expression and clustering maintain low levels of surviving in endothelial cells. Am J Pathol. 165: 181-9. 2004.
  • Llovera M, de Pablo Y, Egea J, Encinas M, Peiró S, Martín-Zanca D, Rocamora N and Comella JX. Trk is a calmodulin-binding protein: Implications for receptor processing.  J Neurochem. 88: 422. 2004