Jose-Javier Bravo-Cordero I High-resolution intravital microscopy reveals the plastic behavior of disseminated dormant cells and their niches
- Speaker: Jose-Javier Bravo-Cordero, Associate Professor (Investigator-Tenure Track) – Tisch Cancer Institute, Division of Hematology/Medical Oncology and Department of Medicine. The Icahn School of Medicine at Mt. Sinai Hospital.
- Talk title: High-resolution intravital microscopy reveals the plastic behavior of disseminated dormant cells and their niches
- Host: Héctor G. Palmer
- Date & time: Friday 23rd September, at 12:00 CET
- Auditorium of the Cellex Building
I am trained as a cell biologist and molecular biologist. My scientific career started as a graduate student at the Spanish National Cancer Institute (CNIO) in Madrid working on mechanisms of tumor cell invasion in 3D collagen matrices by using high-resolution confocal imaging. During my postdoc at the Albert Einstein College of Medicine I strengthen my knowledge and expertise on different imaging techniques such as FRET microscopy and intravital imaging. I studied spatiotemporal activation of RhoGTPases during invasive processes of tumor cells. In order to do that I design a series of imaging tools to study the regulation of GTPase activation in real time in living cells. From these studies, I defined molecular pathways as well as spatiotemporal kinetics of RhoGTPase signaling at invadopodia. My expertise ranges from microscopy to cell biology and mouse models. My studies, highly collaborative in nature, allow me to study tumor cell invasion in different tumor types, from different angles. These studies had uncovered novel functions and pathways in tumor cell invasion instrumental in understanding the early stages of metastasis. The work in my lab is focused on understanding how disseminated cancer cells construct niches to sustain dormancy at metastatic organs such as the lung, liver, brain and the bone marrow. The ultimate goal of my laboratory is to design therapeutic strategies to prevent metastatic recurrence by exploiting the mechanisms that cancer cells utilize to remain dormant at metastatic organs.