Ramon Amat
ramat@vhio.net
Current position
Senior researcher responsible for the Translational Genomics Laboratory in thoracic tumors of the Thoracic Tumors Group
Academic qualification
- PhD in Biochemistry and Molecular Biology, University of Barcelona, 2009. Thesis: Role of sirti1 in the transcriptional control of key genes of muscle energy metabolism
- Graduate in Biology, University of Barcelona, 2004.
Curriculum summary
I completed my PhD at the University of Barcelona in the laboratory of Dr. Francisco Villarroya, where I studied the role of Sirt1 in the transcriptional regulation of genes important for energy metabolism. After finishing my thesis, I continued to train in New York. First, a year in Dr. Lorraine Gudas’ laboratory where I studied the role of retinoic acid receptors in stem cell differentiation. Also in New York, in the laboratory of Dr. Robert Fisher I studied the role of Cyclin-dependent kinases in the regulation of transcription and also as targets in colorectal cancer. After 4 years in the US, I returned to Barcelona, to the laboratory of Dr. Francesc Posas (UFP/PRBB), where I led two lines of research on cellular stress. On the one hand, the impact of stress on chromatin conformation, and on the other I did a massive screening (using CRISPR/Cas9) to identify new essential stress response genes.
In 2019, I started working at VHIO as an associate researcher in the Translational Genomics of Thoracic Tumors laboratory under the umbrella of Dr. Enriqueta Felip, and since 2023 I have been a Senior Researcher. As head of the laboratory, I lead different translational projects focused on the study of molecular biomarkers of response to new therapies in lung cancer, through the characterization of patient samples using different “omics” techniques.
Prizes and grants
- 2014 Marie-Curie Cofund Program (Universitat Pompeu Fabra/European Commission).
- 2011 Beatriu de Pinós (Fase I i II) (Generalitat de Catalunya).
- 2005 Formación Personal Universitario (FPU), Ministerio de Educación y Ciencia
Projects
- 2023-2025 Proyectos de I+D+I en Salud (Instituto de Salud Carlos III). Dissecting the role of somatic copy number alterations as a molecular biomarker in NSCLC.
Most relevant scientific publications
- Carbonell C, Frigola J, Pardo N, Callejo A, Iranzo P, Valdivia A, Priano I, Cedrés S, Martinez-Marti A, Navarro A, Lenza L, Soleda M, Gonzalo-Ruiz J, Vivancos A, Sansó M, Carcereny E, Morán T, Amat R*, Felip E*. Dynamic changes in circulating tumor DNA assessed by shallow whole-genome sequencing associate with clinical efficacy of checkpoint inhibitors in NSCLC. Mol Oncol. 2023 Feb 28. doi: 10.1002/1878-0261.13409 *co-autors de correspondència
- Frigola J, Carbonell C, Irazno P, Pardo N, Callejo A, Cedres S, Martinez-Marti A, Navarro A, Soleda M, Jimenez J, Hernandez-Losa J, Vivancos A, Felip E, Amat R. High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC. J Immunother Cancer. 2022 Apr;10(4):e004197. doi: 10.1136/jitc-2021-004197.
- Serra SA, Stojakovic P, Amat R, Rubio-Moscardo F, Latorre P, Seisenbacher G, Canadell D, Böttcher R, Aregger M, Moffat J, de Nadal E, Valverde MA, Posas F. LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2025013118. doi: 10.1073/pnas.2025013118.
- Frigola J, Navarro A, Carbonell C, Callejo A, Iranzo P, Cedrés S, Martinez-Marti A, Pardo N, Saoudi-Gonzalez N, Martinez D, Jimenez J, Sansano I, Mancuso FM, Nuciforo P, Montuenga LM, Sánchez-Cespedes M, Prat A, Vivancos A, Felip E*, Amat R*. Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer. Mol Oncol. 2021 Apr;15(4):887-900. doi: 10.1002/1878-0261.12891. *co-autor de correspondència.
- Amat R, Böttcher R, Le Dily F, Vidal E, Quilez J, Cuartero Y, Beato M, de Nadal E, Posas F. Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock. Genome Res. 2019 Jan;29(1):18-28. doi: 10.1101/gr.238527.118. Epub 2018 Dec 6
- Kalan S*, Amat R*, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Rep. 2017 Oct 10;21(2):467-481. doi: 10.1016/j.celrep.2017.09.056. *co-primers autors de l’estudi.
- Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol. 2012 Nov;19(11):1108-15. doi: 10.1038/nsmb.2399
- Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. J Biol Chem. 2009 Aug 14;284(33):21872-21880. doi: 10.1074/jbc.M109.022749.