
At the Vall d’Hebron University Hospital’s Department of Radiation Oncology and VHIO, our clinicians and researchers are committed to enhancing patient care through research. Alongside our own research initiatives, we actively engage in numerous national and international projects. As active members of internationally recognized research organizations, such as the European Organisation for Research and Treatment of Cancer (EORTC), the International Society of Paediatric Oncology (SIOP), the GETUG radiation oncology group, and the Radiogenomics consortium, we collaborate to drive advancements in the field.
The VHIO Radiation Oncology Group is a high-technology, internationally connected team dedicated to improving multidisciplinary cancer care through research, innovation, and advanced clinical practice. The department comprises 16 physicians, 40 radiotherapists, and specialized nursing staff, and operates with ISO 9001:2015 and UNE 17009 quality and safety certifications. Equipped with four linear accelerators and a dual-energy CT scanner, the team treats a high volume of complex cases, including more than 80% of pediatric patients in Catalonia requiring radiotherapy, as well as referrals from other Spanish regions and abroad.
The group is strongly integrated into national and international research networks, including EORTC, GETUG, SIOP, Eurocare, IRAD, and the Radiogenomics Consortium, and maintains strategic collaborations with ICMAB-CSIC, UAB, and the Karolinska Proton Center. Within VHIO and VHIR, the team works closely with multiple groups in genetics, prostate cancer, radiomics, and head and neck cancer, supporting both clinical and translational research. In 2025 alone, the group co-authored 30 publications and participated in over 40 clinical trials.
Clinically, the department leads innovation in precision and personalized radiotherapy, implementing respiratory-controlled treatments, deep inspiration breath-hold for breast cancer, image-guided tracking in prostate cancer, adaptive radiotherapy for several tumor sites, stereotactic techniques for oncology and non-oncological indications, and hippocampal-sparing whole-brain irradiation. These approaches aim to maximize tumor control while minimizing toxicity. Internally, we are members of Task Forces focused on various pathologies to help promote research under the VHIR-VHIO umbrella.
Intramurally, we collaborate closely with several VHIO groups, including the Hereditary Cancer Genetics Group led by Judith Balmaña to decipher the genetic causes of underlying normal tissue toxicity after radiotherapy, and with VHIO’s Prostate Cancer Group directed by Joaquin Mateo, also previously co-directed by Joan Carles until July 2025), to study the transcriptomic and protein expression markers influenced by androgen deprivation. We are also expanding our research with VHIO’s Radiomics Group led by Raquel Perez-Lopez. Together with investigators at the MD Anderson Cancer Center, we are working on a patient-reported outcome measures (PROMs) project in head and neck cancer.
In 2025, the Radiation Oncology research group consolidated its international visibility through high-impact publications and active participation in major consortia such as REQUITE, VALIDATE, ARTFORCE, and PREDMORN. Research focuses include adaptive radiotherapy, dose painting, radiogenomics, NTCP modelling, toxicity prediction, and AI-driven projects such as RADGEN-HNC. The group has demonstrated strong competitiveness in funding and has expanded its team with new investigators and PhD projects.
Overall, the Hospital Vall d’Hebron Radiation Oncology Department and VHIO’s Radiation Oncology Group present a coherent and ambitious program that integrates physics, biology, imaging, and clinical oncology, with a clear strategic orientation toward precision, data-driven, and personalized radiotherapy.

- Translate new mechanistic insights into personalized radiation therapy and biomarker-driven strategies tailored to each patient’s clinical and molecular features.
- Increase and strengthen our participation in projects supported through competitive grants.
- Advance clinical research in radiogenomics, nanoparticles, polymorphisms and radioimmunotherapy (RIT), and expand our research in collaboration with VHIO’s Radiomics Group, led by Raquel Perez-Lopez.
- Continue upgrading our equipment to implement cutting-edge radiation oncology techniques, including rotational radiotherapy with volumetric modulated arc therapy (VMAT), radiosurgery (SRS), stereoatactic body radiation therapy (SBRT), respiratory control radiotherapy (RT4D), and image-guided radiotherapy (IGRT).
- Mantain the excellence in quality and safety by ISO 9001/2015 and UNE 17009:2013 certified accreditation program for radiation oncology, and the accreditation by the Organisation of European Cancer Institutes (OECI) for our onco-hematology program at the Vall d’Hebron University Hospital
- Develop digital health solutions and web-based/mobile phone applications for investigators, care providers, and patients.
- Collaborate with our Clinical Research Support Unit (CRSU) in the design and implementation of investigator-initiated clinical trials (IITs) and registries, and provide support for electronic data capture and statistical analysis.
Group Leader
Xavier Maldonado
Radiation Oncologists
Manel Altabas, Sergio Benavente, Josep Garre, André Geng, Alexandra Giraldo, Raquel Granado, Soraya Mico, Begoña Navalpotro, Monica Ramos, Enar Recalde, Victoria Reyes
Postdoctoral Researcher
Laia Humbert-Vidan
Translational Biomedical Scientist
Esperanza Medina
Most relevant scientific publications
- Aguado-Flor E, Reyes VM, Navarro V, Mollà M, Aguado-Barrera ME, Altabas M, Azria D, Baten A, Bourgier C, Bultijnck R, Chang-Claude J, De Santis MC, Dunning AM, Duran-Lozano L, Elliott RM, Farcy Jacquet MP, Giandini C, Giraldo A, Green S, Lambrecht M, Lopez-Pleguezuelos C, Monten C, Rancati T, Rattay T, Rosenstein BS, De Ruysscher D, Diez O, Seibold P, Sperk E, Symonds RP, Stobart H, Vega A, Veldeman L, Villacampa G, Webb AJ, Weltens C, Zunino P, Talbot CJ, West CM, Giralt J, Gutiérrez-Enríquez S; REQUITE consortium. Integrating genetic polymorphisms and clinical data to develop predictive models for skin toxicity in breast cancer radiation therapy. Breast. 2025 Aug;82:104506.
- Roubaud G, Kostine M, McDermott RS, Bernard-Tessier A, Maldonado X, Silva M, Fléchon A, Berthold DR, Ronchin P, Tombal BF, Mourey L, Gravis G, Escande A, Abadie-Lacourtoisie S, Maurina T, Climent MA, Ribault H, Bossi A, Foulon S, Fizazi K. Assessment of bone mineral density in men with de novo metastatic castration-sensitive prostate cancer treated with or without abiraterone acetate plus prednisone in the PEACE-1 phase 3 trial. Eur J Cancer. 2025 Mar 11;218:115293.
- de Leeuw ALMP, Hoebers FJP, Giralt J, Tao Y, Terhaard CHJ, Lee LW, Friesland S, Steenbakkers RJHM, Tans L, Kayembe MT, van Kranen SR, Bartelink H, Rasch CRN, Sonke JJ, Hamming-Vrieze O. Comparing adaptive and dose redistributed radiotherapy to conventional radiotherapy in head and neck cancer – Quality of life results from the phase III ARTFORCE trial. Radiother Oncol. 2025 Sep;210:111044.
- Rousseau A, Karimi M, Michiels S, Roubaud G, Maldonado X, Supiot S, McDermott R, Flechon A, Tombal B, Ronchin P, Berthold D, Berdah JF, Kacso G, Gravis G, Calabro F, Tartas S, Muracciole X, Ribault H, Fizazi K, Foulon S. Adjusting for abiraterone-prednisone cross-over in de novo metastatic castration-sensitive prostate cancer: a post-hoc analysis of the PEACE-1 trial.Eur J Cancer. 2025 Nov 17;230:116024.
- Bossi A, Foulon S, Maldonado X, Sargos P, MacDermott R, Kelly P, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Salem N, Calabro F, Berdah JF, Hasbini A, Silva M, Boustani J, Ribault H, Fizazi K; PEACE-1 investigators. Efficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. Lancet. 2024 Nov 23;404(10467):2065-2076.
- Ong WL, Romero T, Roy S, Nikitas J, Joseph D, Zapatero A, Malone S, Morgan SC, Steinberg ML, Valle LF, Zaorsky NG, Martin Ma T, Rettig MB, Nickols N, Jiang T, Reiter RE, Eleswarapu SV, Maldonado X, Sun Y, Nguyen PL, Millar JL, Martin JM, Spratt DE, Kishan AU; MARCAP Consortium Investigators. Testosterone Recovery Following Androgen Suppression and Prostate Radiotherapy (TRANSPORT): A Pooled Analysis of Five Randomized Trials from the Meta-Analysis of Randomized Trials in Cancer of the Prostate (MARCAP) Consortium. Eur Urol. 2024. doi: 10.1016/j.eururo.2024.09.009.
- de Leeuw ALMP, Giralt J, Tao Y, Benavente S, France Nguyen TV, Hoebers FJP, Hoeben A, Terhaard CHJ, Wai Lee L, Friesland S, Steenbakkers RJHM, Tans L, Heukelom J, Kayembe MT, van Kranen SR, Bartelink H, Rasch CRN, Sonke JJ, Hamming-Vrieze O. A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE). Radiother Oncol. 2024 Jul;196:110281.
- Timmermann B, Alapetite C, Dieckmann K, Kortmann RD, Lassen-Ramshad Y, Maduro JH, Ramos Albiac M, Ricardi U, Weber DC. ESTRO-SIOPE guideline: Clinical management of radiotherapy in atypical teratoid/rhabdoid tumors (AT/RTs). Radiother Oncol. 2024 Jul;196:110227.
- Kroeze SGC, Pavic M, Stellamans K, Lievens Y, Becherini C, Scorsetti M, Alongi F, Ricardi U, Jereczek-Fossa BA, Westhoff P, But-Hadzic J, Widder J, Geets X, Bral S, Lambrecht M, Billiet C, Sirak I, Ramella S, Giovanni Battista I, Benavente S, Zapatero A, Romero F, Zilli T, Khanfir K, Hemmatazad H, de Bari B, Klass DN, Adnan S, Peulen H, Salinas Ramos J, Strijbos M, Popat S, Ost P, Guckenberger M. Metastases-directed stereotactic body radiotherapy in combination with targeted therapy or immunotherapy: systematic review and consensus recommendations by the EORTC-ESTRO OligoCare consortium. Lancet Oncol. 2023 Mar;24(3):e121-e132.
- Ma TM, Sun Y, Malone S, Roach M 3rd, Dearnaley D, Pisansky TM, Feng FY, Sandler HM, Efstathiou JA, Syndikus I, Hall EC, Tree AC, Sydes MR, Cruickshank C, Roy S, Bolla M, Maingon P, De Reijke T, Nabid A, Carrier N, Souhami L, Zapatero A, Guerrero A, Alvarez A, Gonzalez San-Segundo C, Maldonado X, Romero T, Steinberg ML, Valle LF, Rettig MB, Nickols NG, Shoag JE, Reiter RE, Zaorsky NG, Jia AY, Garcia JA, Spratt DE, Kishan AU; Meta-Analysis of Randomized Trials in Cancer of the Prostate (MARCAP) Consortium Investigators. Sequencing of Androgen-Deprivation Therapy of Short Duration With Radiotherapy for Nonmetastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials. J Clin Oncol. 2023 Feb 1;41(4):881-892.
- Jandu HK, Veal CD, Fachal L, Luccarini C, Aguado-Barrera ME, Altabas M, Azria D, Baten A, Bourgier C, Bultijnck R, Colciago RR, Farcy-Jacquet MP, Chang-Claude J, Choudhury A, Dunning A, Elliott RM, Green S, Gutiérrez-Enríquez S, Herskind C, Lambrecht M, Monten C, Rancati T, Reyes V, Rosenstein BS, De Ruysscher D, Carmen De Santis M, Seibold P, Sperk E, Veldwijk M, Paul Symonds R, Stobart H, Taboada-Valladares B, Vega A, Veldeman L, Webb AJ, Weltens C, West CM, Rattay T, Talbot CJ; REQUITE consortium. Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer. Radiother Oncol. 2023 Oct;187:109806.
- Giraldo A, Geng AAA, Ramos M, Recalde E, Garre J, Maldonado X, Giralt J. et al. Evaluation of Pulmonary Functions by Spirometry after Stereotactic Body Radiotherapy in Lung Tumors. Medical Research Archives, [S.l.], v. 11, n. 6, june 2023. ISSN 2375-1924.
- Kishan AU, Steigler A, Denham JW, Zapatero A, Guerrero A, Joseph D, Maldonado X, Wong JK, Stish BJ, Dess RT, Pilar A, Reddy C, Wedde TB, Lilleby WA, Fiano R, Merrick GS, Stock RG, Demanes DJ, Moran BJ, Tran PT, Martin S, Martinez-Monge R, Krauss DJ, Abu-Isa EI, Pisansky TM, Choo CR, Song DY, Greco S, Deville C, McNutt T, DeWeese TL, Ross AE, Ciezki JP, Tilki D, Karnes RJ, Tosoian JJ, Nickols NG, Bhat P, Shabsovich D, Juarez JE, Jiang T, Ma TM, Xiang M, Philipson R, Chang A, Kupelian PA, Rettig MB, Feng FY, Berlin A, Tward JD, Davis BJ, Reiter RE, Steinberg ML, Elashoff D, Boutros PC, Horwitz EM, Tendulkar RD, Spratt DE, Romero T. Interplay Between Duration of Androgen Deprivation Therapy and External Beam Radiotherapy With or Without a Brachytherapy Boost for Optimal Treatment of High-risk Prostate Cancer: A Patient-Level Data Analysis of 3 Cohorts. JAMA Oncol. 2022 Mar 1;8(3):e216871.
- Zapatero A, Guerrero A, Maldonado X, Álvarez A, San-Segundo CG, Rodríguez MÁC, Solé JM, Olivé AP, Casas F, Boladeras A, de Vidales CM, de la Torre MLV, Vara S, Sanz JL, Calvo FA. High-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial. Lancet Oncol. 2022 May;23(5):671-681.
- Kishan AU, Sun Y, Hartman H, Pisansky TM, Bolla M, Neven A, Steigler A, Denham JW, Feng FY, Zapatero A, Armstrong JG, Nabid A, Carrier N, Souhami L, Dunne MT, Efstathiou JA, Sandler HM, Guerrero A, Joseph D, Maingon P, de Reijke TM, Maldonado X, Ma TM, Romero T, Wang X, Rettig MB, Reiter RE, Zaorsky NG, Steinberg ML, Nickols NG, Jia AY, Garcia JA, Spratt DE; MARCAP Consortium group. Androgen deprivation therapy use and duration with definitive radiotherapy for localised prostate cancer: an individual patient data meta-analysis. Lancet Oncol. 2022 Feb;23(2):304-316.
- Biau J, Nutting C, Langendijk JA, Frédéric-Moreau T, Thariat J, Piram L, Bellini R, Saroul N, Pham Dang N, O’Sullivan B, Giralt J, Blanchard P, Bourhis J, Lapeyre M. Radiographic-anatomy, natural history and extension pathways of parotid and submandibular gland cancers. Radiother Oncol. 2022 May;170:48-54.
- Vázquez M, Altabas M, Moreno DC, Geng AA, Pérez-Hoyos S, Giralt J. 30-Day Mortality Following Palliative Radiotherapy. Front Oncol. 2021 Apr 23;11:668481.
- Huijskens SC, Kroon PS, Gaze MN, Gandola L, Bolle S, Supiot S, Abakay CD, Alexopoulou A, Bokun J, Chojnacka M, Escande A, Giralt J, Harrabi S, Maduro JH, Mandeville H, Mussano A, Napieralska A, Padovani L, Scarzello G, Timmermann B, Claude L, Seravalli E, Janssens GO. Radical radiotherapy for paediatric solid tumour metastases: An overview of current European protocols and outcomes of a SIOPE multicenter survey. Eur J Cancer. 2021 Mar;145:121-131.
- Zapatero A, Álvarez A, Guerrero A, Maldonado X, González San Segundo C, Cabeza MA, Martín de Vidales C, Solé JM, Pedro Olivé A, Casas F, Boladeras A, Vázquez de la Torre ML, Vara S, Calvo FA. Prognostic value of testosterone castration levels following androgen deprivation and high-dose radiotherapy in localized prostate cancer: Results from a phase III trial. Radiother Oncol. 2021 Jul;160:115-119.
- Warren GW, Lim VS, Chowdhary M, Marwaha G, Abd Elbadee OM, Kirakli EK, Billiet C, Marin AG, Ramos M, Suppli MH, McGinnis GJ, Adjei AA. New Pulmonary Infiltrates Observed on Computed Tomography-Based Image Guidance for Radiotherapy Warrant Diagnostic Workup for Coronavirus Disease 2019. J Thorac Oncol. 2021 Nov;16(11):1946-1951.
- Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N, Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS. Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement. Radiother Oncol. 2020 Oct;151:314-321.
- Giralt J, Tao Y, Kortmann RD, Zasadny X, Contreras-Martinez J, Ceruse P, Arias de la Vega F, Lalla RV, Ozsahin EM, Pajkos G, Mazar A, Attali P, Bossi P, Vasseur B, Sonis S, Henke M, Bensadoun RJ. Randomized Phase 2 Trial of a Novel Clonidine Mucoadhesive Buccal Tablet for the Amelioration of Oral Mucositis in Patients Treated With Concomitant Chemoradiation Therapy for Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):320-328.
- Rattay T, Seibold P, Aguado- Barrera ME, Altabas M, Azria D, Barnett GC, Bultijnck R, Chang-Claude J, Choudhury A, Coles CE, Dunning AM, Elliott RM, Farcy Jacquet MP, Gutiérrez- Enríquez S, Johnson K, Müller A, Post G, Rancati T, Reyes V, Rosenstein BS, De Ruysscher D, de Santis MC, Sperk E, Stobart H, Symonds RP, Taboada- Valladares B, Vega A, Veldeman L, Webb AJ, West CM, Valdagni R, Talbot CJ; REQUITE consortium. External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort. Front Oncol. 2020 Oct 30;10:575909.
- López-Campos F, Linares- Espinós E, Maldonado Pijoan X, Sancho Pardo G, Morgan TM, Martínez-Ballesteros C, Martínez-Salamanca J, Couñago F. Genetic testing for the clinician in prostate cancer. Expert Rev Mol 2020 Sep;20(9):933-946.
- Verges R, Giraldo A, Seoane A, Toral E, Ruiz MC, Pons A, Giralt J. Does ITV vaginal procedure ensure dosimetric coverage during IMRT of post-operative gynaecological tumours without instructions concerning rectal filling? Rep Pract Oncol Radiother. 2018 Mar-Apr;23(2):136-142.
- Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2018 Apr;16(2):e491-e496.
- Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group. SIOPE – Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. Radiother Oncol. 2018 Aug;128(2):192-197.
- Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2018 Jan;126(1):3-24.
- Rueda A, Giralt J, Mañós M, Lozano A, Sistiaga A, García-Miragall E, Cacicedo J, Esteban F, Scola B, Contreras J, Ruiz A, Carral A, Sanchez-Aniceto G, Pastor M, Herranz JJ, Bernal M, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 2). Oral Oncol. 2017 Jul;70:65-72. doi: 10.1016/j.oraloncology.2017.04.005.
- Mañós M, Giralt J, Rueda A, Cabrera J, Martinez-Trufero J, Marruecos J, Lopez-Pousa A, Rodrigo JP, Castelo B, Martínez-Galán J, Arias F, Chaves M, Herranz JJ, Arrazubi V, Baste N, Castro A, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1). Oral Oncol. 2017 Jul;70:58-64. doi: 10.1016/j.oraloncology.2017.04.004.
- Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol. 2017 Dec 14. doi: 10.1007/s11523-017-0544-z.
- Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2017 Nov 24. pii: S0167-8140(17)32656-7. doi: 10.1016/j.radonc.2017.10.016.
- Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2017 Nov 30. pii: S1558-7673(17)30341-5. doi: 10.1016/j.clgc.2017.10.025.
- Casas F, Henríquez I, Bejar A, Maldonado X, Alvarez A, González-Sansegundo C, Boladeras A, Ferrer F, Hervás A, Herruzo I, Caro M, Rodriguez I, Ferrer C. Intermittent versus continuous androgen deprivation therapy to biochemical recurrence after external beam radiotherapy: a phase 3 GICOR study. Clin Transl Oncol. 2017 Mar;19(3):373-378. doi: 10.1007/s12094-016-1538-5.
- Martínez-Garcia M, Álvarez-Linera J, Carrato C, Ley L, Luque R, Maldonado X, Martínez-Aguillo M, Navarro LM, Vaz-Salgado MA, Gil-Gil M. SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017). Clin Transl Oncol. 2017 Oct 30. doi:10.1007/s12094-017-1763-6.
- Toledo M, Sarria-Estrada S, Quintana M, Maldonado X, Martinez-Ricarte F, Rodon J, Auger C, Aizpurua M, Salas-Puig J, Santamarina E, Martinez-Saez E. Epileptic features and survival in glioblastomas presenting with seizures. Epilepsy Res. 2017 Feb;130:1-6.doi:10.1016/j.eplepsyres.2016.12.013.
- Giraldo A, Benavente S, Ramos M, Vergés R, Coronil O, Arbeláez L, Maldonado X, Altabas M, Mollà M, Reyes V, Navalpotro B, Giralt J. Effectiveness of radiotherapy for metastatic spinal cord compression in patients with short life expectancy. Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):58-63.
- Regis L, Planas J, Carles J, Maldonado X, Comas I, Ferrer R, Morote J. Free Testosterone During Androgen Deprivation Therapy Predicts Castration-Resistant Progression Better Than Total Testosterone. 2017 Jan;77(1):114-120. doi: 10.1002/pros.23256.
- Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). A phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol. 2017 Nov 11. doi: 10.1007/s11523-017-0536-z.
- Cambra MJ, Farrús B, Moreno F, Anglada L, Arenas M, Ballester R, Casals J, Cusidó M, García V, Gutiérrez C, Mollà M, Pedro A, Reyes V, Sanz X. Management of breast ductal carcinoma in situ in Catalonia, Spain: Results from the Grup Oncologic Calalà-Occità-Catalonia survey with 9-year follow up. Breast. 2017 Oct;35:196-202. doi: 10.1016/j.breast.2017.08.002.
- Christiaens M, Collette S, Overgaard J, Gregoire V, Kazmierska J, Castadot P, Giralt J, Grant W, Tomsej M, Bar-Deroma R, Monti AF, Hurkmans CW, Weber DC. Quality assurance of radiotherapy in the ongoing EORTC 1219-DAHANCA-29 trial for HPV/p16 negative squamous cell carcinoma of the head and neck: Results of the benchmark case procedure. Radiother Oncol. 2017 Jun;123(3):424-430. doi: 10.1016/j.radonc.2017.04.019.
- Prades J, Algara M, Espinàs JA, Farrús B, Arenas M, Reyes V, García-Reglero V, Cambra MJ, Rubio E, Anglada L, Eraso A, Pedro A, Fuentes-Raspall MJ, Tuset V, Solà J, Borras JM. Understanding variations in the use of hypofractionated radiotherapy and its specific indications for breast cancer: A mixed-methods study. Radiother Oncol. 2017 Apr;123(1):22-28. doi: 10.1016/j.radonc.2017.01.014.
- Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, Morales La Madrid A, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM. Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group. Eur J Cancer. 2017 Mar;73:38-47. doi: 10.1016/j.ejca.2016.12.007.
- Gutiérrez Santamaría J, Masiá Gridilla J, Pamias Romero J, Giralt López-de-Sagredo J, Bescós Atín MS. Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment. J Craniomaxillofac Surg. 2017 Jan;45(1):93-98. doi: 10.1016/j.jcms.2016.10.019.
- Bonner JA, Mesia R, Giralt J, Psyrri A, Keilholz U, Rosenthal DI, Beier F, Schulten J, Vermorken JB.p16, HPV, and Cetuximab: What Is the Evidence? Oncologist. 2017 Jul;22(7):811-822. doi: 10.1634/theoncologist.2016-0433.
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- Zapatero, A, Guerrero A, Maldonado X, Alvarez A, Gonzàlez Sansegundo C, Cabeza MA, Macias V, Olivé P, Casas F, Boladeras A, Martin de Vidales C, Vázquez de la Torre M, Calvo F Late Radiation and cardiovascular adverse effects following androgen deprivation and high dose radiotherapy in prostate cáncer: Results fron DART 01/05 Randomized Phase III trial. Int J Radiation Oncol Biol Phys, 2016 Vol. 96, Issue 2, 341–348.
- Bonner J, Giralt J, Harari P, Spencer S, Schulten J, Hossain A, Chang SC, Chin S, Baselga J. Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: A Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2016 Sep 1;142(9):842-9.
- Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CM, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, Chang-Claude J, Seibold P, Popanda O, Overgaard M, Dearnaley D, Sydes MR, Azria D, Koch CA, Parliament M, Blackshaw M, Sia M, Fuentes-Raspall MJ, Ramon Y Cajal T, Barnadas A, Vesprini D, Gutiérrez-Enríquez S, Mollà M, Díez O, Yarnold JR, Overgaard J, Bentzen SM, Alsner J. International Radiogenomics Consortium (RgC). Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. Radiother Oncol. 2016 Dec;121(3):431-439.
- Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A. Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015;16(2):221-232.
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- Bosset JF, Calais G, Mineur L, Maingon P, Stojanovic-Rundic S, Bensadoun RJ, Bardet E, Beny A, Ollier JC, Bolla M, Marchal D, Van Laethem JL, Klein V, Giralt J, Clavère P, Glanzmann C, Cellier P, Collette L. Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol. 2014 Feb; 15(2): 184-90
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All publications
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- Humbert-Vidan L, Hansen CR, Petit S, Muñoz-Montplet C, Mohamed ASR, Saunders DP, Patel V, Verduijni GM, Heemsbergen WD, van der Schaaf A, Witjes M, de Vette S, Khan AA, Marruecos Querol J, Oliveras Cancio I, Oliver M, Reich P, Santi SA, Pearce AG, Lai SY, King AP, Langendijk JA, Johansen J, Moreno AC, Fuller CD, van Dijk LV, Guerrero Urbano T, et al. Multi-institutional Normal Tissue Complication Probability (NTCP) Prediction Model for Mandibular Osteoradionecrosis: Results from the PREDMORN Study. Int J Radiat Oncol Biol Phys. 2025; [Epub ahead of print]. doi:10.1016/j.ijrobp.2025.12.044
- de Pablo Garcia-Cuenca, A.; Rofin-Fontanet, P.; Lorente-Guerrero, J.; Balmana-Gelpi, J.; Carrasco-Lopez, E.; Temprana-Salvador, J.; Granado- Carrasco, R.; Brana-Garcia, I.; Vaquero Martinez, P.; Pujol-Pina, R.; et al. Head and Neck Cancer in Fanconi Anemia: Report of 11 Cases and a Systematic Review. Cancers. 2025, 17, 349. https://doi.org/10.3390/ cancers17030349
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- ICO-ICS PRAXIS para el tratamiento médico-quirúrgico y con irradiación de los tumores cutáneos. Actualización junio de 2025ISBN: 978-84-128170-5-8 ISBN: 978-84-128170-4-1 http://hdl.handle.net/11351/13729.
- Bossi A, Foulon S, Maldonado X, Sargos P, MacDermott R, Kelly P, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Salem N, Calabro F, Berdah JF, Hasbini A, Silva M, Boustani J, Ribault H, Fizazi K; PEACE-1 investigators. Efficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. Lancet. 2024 Nov 23;404(10467):2065-2076. doi: 10.1016/S0140-6736(24)01865-8. Erratum in: Lancet. 2025 May 10;405(10490):1665. doi: 10.1016/S0140-6736(25)00903-1.
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- de Leeuw ALMP, Giralt J, Tao Y, Benavente S, France Nguyen TV, Hoebers FJP, Hoeben A, Terhaard CHJ, Wai Lee L, Friesland S, Steenbakkers RJHM, Tans L, Heukelom J, Kayembe MT, van Kranen SR, Bartelink H, Rasch CRN, Sonke JJ, Hamming-Vrieze O. A multicentric randomized controlled phase III trial of adaptive and 18F-FDG-PET-guided dose-redistribution in locally advanced head and neck squamous cell carcinoma (ARTFORCE). Radiother Oncol. 2024 Jul;196:110281. doi: 10.1016/j.radonc.2024.110281.
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- Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2018 Apr;16(2):e491-e496. doi: 10.1016/j.clgc.2017.10.025.
- Martínez-Garcia M, Álvarez-Linera J, Carrato C, Ley L, Luque R, Maldonado X, Martínez-Aguillo M, Navarro LM, Vaz-Salgado MA, Gil-Gil M. SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017). Clin Transl Oncol. 2018 Jan;20(1):22-28. doi: 10.1007/s12094-017-1763-6.
- Rodríguez A, Algara M, Monge D, López-Torrecilla J, Caballero F, Morera R, Escó R, Pérez-Montero H, Ferrer C, Lara PC; Spanish Society of Oncology and Radiotherapy (SEOR) Analysis Group. Infrastructure and equipment for radiation oncology in the Spanish National Health System: analysis of external beam radiotherapy 2015-2020. Clin Transl Oncol. 2018 Mar;20(3):402-410. doi: 10.1007/s12094-017-1727-x. Collaboradors: Ortiz MJ, Expósito J, Palacios A, Herruzo I, Medina JA, Martinez M, Bayo E, Jaén J, Peracaula FJ, Pérez C, Ramos MI, González JA, López E, Begara J, Nuño C, Bezares AB, Serradilla A, Lazo A, Tejedor M, Méndez L, Juan G, Olay L, Pardo J, Mestre F, Otón C, Fuentes C, Prada P, Pérez L, Lozano E, Villas MV, Tripero J, Lobo R, Muñoz M, Tisaire JL, Fernández J, Teijeira M, Rodríguez JR, Pérez L, López F, Ceballos A, Cantalapiedra R, Biete A, Craven J, Pedro A, Giralt J, Guedea F, Villá S, Solé JM, Eraso A, Carceller JA, Arenas M, Guix B, Miralbell R, Casals J, Muñoz J, González P, Duarte MI, Jerez JP, Mariño A, Gómez A, Muñoz V, López MD, Zugazabeitia L, Ossola G, Mañas A, Cerezo L, Ramos A, Pérez-Regadera J, Lozano MA, de Las Heras M, Pérez A, Torre A, Samper P, Ludeña B, de Dios Sáez J, Azinovic I, Rubio C, Del Cerro E, Meiriño R, García-Alejo R, Carballo N, García R, Salinas J, Fontevilla A, Martinez R, Martinez E, Alia A, Ciria JP, Rosa J, Bilbao P, Martin JC, Casquero F, Arribas L, Tormo A, Algas A, Larrea L, Soler M, Garcia E, Soler P, Santos M, Vázquez G, Cañón RM, Miró A.
- Cabrera Rodríguez J, Cacicedo J, Giralt J, García Miragall E, Lloret M, Arias F, González Ruiz MA, Contreras J. GEORCC recommendations on target volumes in radiotherapy for Head Neck Cancer of Unkown Primary. Crit Rev Oncol Hematol. 2018 Oct;130:51-59. doi: 10.1016/j.critrevonc.2018.07.006.
- Verges R, Giraldo A, Seoane A, Toral E, Ruiz MC, Pons A, Giralt J. Does ITV vaginal procedure ensure dosimetric coverage during IMRT of post-operative gynaecological tumours without instructions concerning rectal filling? Rep Pract Oncol Radiother. 2018 Mar-Apr;23(2):136-142. doi: 10.1016/j.rpor.2018.01.006.
- Gnekow AK, Walker DA, Kandels D, Picton S, Giorgio Perilongo, Grill J, Stokland T, Sandstrom PE, Warmuth-Metz M, Pietsch T, Giangaspero F, Schmidt R, Faldum A, Kilmartin D, De Paoli A, De Salvo GL; Low Grade Glioma Consortium and the participating centers. Corrigendum to “A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma – A final report” [Eur J of Canc (2017) 206-225]. Eur J Cancer. 2018 Feb;90:156-157. doi: 10.1016/j.ejca.2017.11.017. Collaboradors: Gnekow AK, Slavc I, Perilongo G, Picton S, Walker D, Stokland T, Sandstrom PE, Clausen N, Arola M, Jonsson OG, Cruz O, Navajas A, Teijeiro A, Grill J, Kalifa C, Raquin MA, Verlooy J, Hans V, Pietsch T, Scheurlen W, Hainfellner J, Giangaspero F, Ironside J, Robson K, Skullerud K, Scheie D, Nn, Ruchoux MM, Jouvet A, Figarella-Branger D, Lellouch-Toubiana A, Warmuth-Metz M, Prayer D, Calderone M, Jaspan T, Bakke SJ, Vazquez E), Couanet D, Kortmann RD, Diekmann K, Scarzello G, Taylor R, Lote K, Giralt J, Carrie C, Habrand JL, Soerensen N, Czech T, Chumas P, Gustavson B, Zerah M, Wabbels B, Pinello ML, Fielder A, Simmons I, Christoffersen T, Calaminus G, Brockmann K, Straeter R, Ebinger F, Hernaiz-Driever P, Lackner H, Kennedy C, Glaser A, Stromberg B, Indiano JM, Rodary C, Bouffet E, Frappaz D, Faldum A, Emser A, De Salvo GL, Stephens S, Machin D, Le Deley MC, Egeland T, Freemann C, Schrappe M, Sposto R.
- Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol.2018 Feb;13(1):79. doi:10.1007/s11523-017-0544-z.
- Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2018 Jan;126(1):3-24. doi: 10.1016/j.radonc.2017.10.016.
- Lobon-Iglesias MJ, Santa-Maria Lopez V, Puerta Roldan P, Candela-Cantó S, Ramos-Albiac M, Gomez-Chiari M, Puget S, Bolle S, Goumnerova L, Kieran MW, Cruz O, Grill J, Morales La Madrid A. Tumor dissemination through surgical tracts in diffuse intrinsic pontine glioma. J Neurosurg Pediatr. 2018 Sep 7:1-6. doi: 10.3171/2018.6.PEDS17658.
- Matamalas A, Valverde C, Benavente S, Casas-Gomila L, Romagosa C, González-Tartière P, Pellisé F. Team Approach: Metastatic Disease of the Spine. JBJS Rev. 2018 May;6(5):e6. doi: 10.2106/JBJS.RVW.17.00118.
- Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group. SIOPE – Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. Radiother Oncol. 2018 Aug;128(2):192-197. doi: 10.1016/j.radonc.2018.04.016.
- CDK4/6 Inhibitors in Breast Cancer: Consensus Workshop on the Management of Concomitant Medication. Bellet, Meritxell; Ahmad, Faten; Valdivia, Carolina; Palomino-Doza , Julián; Gonzàlez, Xavier; Adrover, Encarna; Azaro, Analía; Vidal, Maria Martín, Anastasi; Escrivá-de-Romaní , Santiago; Perelló, Antonia; Hernando, Cristina; Lahuerta , Ainhara ; Zamora, Pilar; Reyes, Victoria ; Alcalde, María; Masanas, Helena; Ruíz, Isabel; Gil, Miguel; Seguí, Miguel and de la Peña, Lorena. Therapeutic Advances in Medical Oncology. Accepted in press.
- Rueda A, Giralt J, Mañós M, Lozano A, Sistiaga A, García-Miragall E, Cacicedo J, Esteban F, Scola B, Contreras J, Ruiz A, Carral A, Sanchez-Aniceto G, Pastor M, Herranz JJ, Bernal M, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 2). Oral Oncol. 2017 Jul;70:65-72. doi: 10.1016/j.oraloncology.2017.04.005.
- Mañós M, Giralt J, Rueda A, Cabrera J, Martinez-Trufero J, Marruecos J, Lopez-Pousa A, Rodrigo JP, Castelo B, Martínez-Galán J, Arias F, Chaves M, Herranz JJ, Arrazubi V, Baste N, Castro A, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1). Oral Oncol. 2017 Jul;70:58-64. doi: 10.1016/j.oraloncology.2017.04.004.
- Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol. 2017 Dec 14. doi: 10.1007/s11523-017-0544-z.
- Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2017 Nov 24. pii: S0167-8140(17)32656-7. doi: 10.1016/j.radonc.2017.10.016.
- Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2017 Nov 30. pii: S1558-7673(17)30341-5. doi: 10.1016/j.clgc.2017.10.025.
- Casas F, Henríquez I, Bejar A, Maldonado X, Alvarez A, González-Sansegundo C, Boladeras A, Ferrer F, Hervás A, Herruzo I, Caro M, Rodriguez I, Ferrer C. Intermittent versus continuous androgen deprivation therapy to biochemical recurrence after external beam radiotherapy: a phase 3 GICOR study. Clin Transl Oncol. 2017 Mar;19(3):373-378. doi: 10.1007/s12094-016-1538-5.
- Martínez-Garcia M, Álvarez-Linera J, Carrato C, Ley L, Luque R, Maldonado X, Martínez-Aguillo M, Navarro LM, Vaz-Salgado MA, Gil-Gil M. SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017). Clin Transl Oncol. 2017 Oct 30. doi:10.1007/s12094-017-1763-6.
- M.Molla, N.Anducas, M. Simó, A.Seoane, M.Ramos, G. Cuberas, M. Beltran, J. Castell, J. Giralt. A comparative study of the target volume definition in radiotherapy with “Slow CT Scan” vs 4D PET/CT Scan in early stages non-small cell lung cancer. Rev Esp Med Nucl Imagen Mol, available online 19 Apr 2016. DOI: 10.1016/j.remn.2016.02.003.
- Regis L, Planas J, Carles J, Maldonado X, Comas I, Ferrer R, Morote J. Free Testosterone During Androgen Deprivation Therapy Predicts Castration –Resistant Progression Better Than Total Testosterone. The Prostate, 2016, DOI 10.1002/pros.23526; 1-7
- F. Casas, I. Henríquez. A. Bejar, X. Maldonado, A. Alvarez,C. González-Sansegundo A. Boladeras, F. Ferrer, A. Hervás, I. Herruzo, M. Caro, I. Rodriguez, C. Ferrer. Intermittent versus continuous androgen deprivation therapy to biochemical recurrence after external beam radiotherapy: a phase 3 GICOR study. Clin Translat Oncol 2016; 1-6, First Online: 21 October 2016 DOI: 10.1007/s12094-016-1538-5
- Morales R, Suarez C., Martinez de Castro AM., Racca F., Valverde C., Maldonado X., Bastaros JM, Morote J., Carles J. Targeting fibroblast growth factor receptors and immune check point inhibitors of advanced bladder cancer: New direction and Hope. Cancer Treatment Reviews 50 (2016) 208-2016
- Zapatero, A., Guerrero A., Maldonado X., Alvarez A., Gonzàlez Sansegundo C, Cabeza MA., Macias V., Olivé P., Casas F., Boladeras A., Martin de Vidales C., Vázquez de la Torre M., Calvo F. Late Radiation and cardiovascular adverse effects following androgen deprivation and high dose radiotherapy in prostate cáncer: Results fron DART 01/05 Randomized Phase III trial. Int J. Radiat oncol Biol Phys, 2016 Vol. 96, Issue 2, 341–348
- Planas J, Celma A., Placer J., Maldonado X., Trilla E., Salvador C., LLorente D., Regis L., Cuadras M., Carles J., Morote J. Hormonal changes after localized prostate cancer treatment. Comparison between external beam radiation therapy and radical prostatectomy.” (ref. Acuro-d-16-00024r1), Actas Urol Esp, vol 40, Mayo 2016
- Gómez Caamaño A, Zapatero A, López Torrecilla J, Maldonado X. Management of prostate cancer patients following radiation therapy after radical surgery referred from urology to radiation oncology departments in Spain. Clin Transl Oncol Clin Transl Oncol. 2016 Sep;18(9):884-92. doi: 10.1007/s12094-015-1454-0.
- Morote J., Maldonado X., Morales R. Cáncer de próstata. Med Clin (Barc). Vol. 146 Núm. 03 Febrero 2016. pii: S0025-7753(15)00041-X. doi: 10.1016/j.medcli.2014.12.021. [Epub ahead of print]
- Mollà M, Saez J, Ramos M, Giraldo A, Seoane A, Andreu J, Simó M, Giralt J. Hypofractionated 3d Radiotherapy for inoperable T1-3 N0-1 non-small cell lung cancer. Br J Radiol. 2016 Mar 17:20150824. [Epub ahead of print] PMID: 26986457
- Barrera-Ochoa S, Gallardo-Calero I, Sallent A, López-Fernández A, Vergés R, Giralt J, Aguirre-Canyadell M, Velez R. New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research. Lab Anim. 2016 Jun 29. pii: 0023677216656221. [Epub ahead of print] PMID: 27357187
- Bonner JA, Giralt J, Harari PM, Baselga J, Spencer S, Bell D, Raben D, Liu J, Schulten J, Ang KK, Rosenthal DI. Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment from a phase 3 registration trial. Eur J Cancer. 2016 Jun 17;64:1-11. doi: 10.1016/j.ejca.2016.05.008. [Epub ahead of print] PMID: 27323346
- Bonner J, Giralt J, Harari P, Spencer S, Schulten J, Hossain A, Chang SC, Chin S, Baselga J. Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: A Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2016 Jul 7.
- J. Gutiérrez , J. Masiá , J. Pamias, J. Giralt, M.S. Bescós. Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment. Journal of Cranio-Maxillofacial Surgery. 2017 Jan;45(1):93-98. doi:10.1016/j.jcms.2016.10.019. Epub 2016 Nov 1.
- Giraldo A, Benavente S, Ramos M, Vergés R, Coronil O, Arbeláez L, Maldonado X, Altabas M, Mollà M, Reyes V, Navalpotro B, Giralt J. Effectiveness of radiotherapy for metastatic spinal cord compression in patients with short life expectancy. Reports of Practical Oncology & Radiotherapy 2017, 22;1: 58-63.
- Garcia del Muro X, de Alava E, Artigas V, Bague S, Braña A, Cubedo R, Cruz J, Mulet-Margalef N, Narvaez JA, Martinez Tirado O, Valverde C, Verges R, Viñals J, Martin-Broto J. Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS). Cancer Chemother Pharmacol. 2016 Jan;77(1):133-46. doi: 10.1007/s00280-015-2809-5. Epub 2015 Nov 12.
- Serrano C, Romagosa C, Hernández-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Vergés R, Domínguez R, Carles J, Ramón Y Cajal S. RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Cancer. 2016 Jan 1;122(1):99-107. doi: 10.1002/cncr.29733. Epub 2015 Oct 19.
- Barrera-Ochoa S, Gallardo-Calero I, López-Fernández A, Romagosa C, Vergés R, Aguirre-Canyadell M, Soldado F, Velez R. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats. Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. DOI: 10.1097/GOX.0000000000001073
- Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CM, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, Chang-Claude J, Seibold P, Popanda O, Overgaard M, Dearnaley D, Sydes MR, Azria D, Koch CA, Parliament M, Blackshaw M, Sia M, Fuentes-Raspall MJ, Ramon Y Cajal T, Barnadas A, Vesprini D, Gutiérrez-Enríquez S, Mollà M, Díez O, Yarnold JR, Overgaard J, Bentzen SM, Alsner J; International Radiogenomics Consortium (RgC). Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. Radiother Oncol. 2016 Dec;121(3):431-439. doi: 10.1016/j.radonc.2016.06.017. Epub 2016 Jul 18.
- Rosenthal DI, Harari PM, Giralt J, Bell D, Raben D, Liu J, Schulten J, Ang KK, Bonner JA. Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab. J. Clin. Oncol. 2016 Apr; 34(12): 1300-8
- Mesia R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J. Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015 Feb; 16(2): 208-20
- Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesia R, Zhang A, Oliner KS, VanderWalde A. Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015 Feb; 16(2): 221-32
- Bosset JF, Calais G, Mineur L, Maingon P, Stojanovic-Rundic S, Bensadoun RJ, Bardet E, Beny A, Ollier JC, Bolla M, Marchal D, Van Laethem JL, Klein V, Giralt J, Clavère P, Glanzmann C, Cellier P, Collette L. Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol. 2014 Feb; 15(2): 184-90
- Sclafani F, González D, Cunningham D, Hulkki Wilson S, Peckitt C, Giralt J, Glimelius B, Roselló Keränen S, Wotherspoon A, Brown G, Tait D, Oates J, Chau I. RAS mutations and cetuximab in locally advanced rectal cancer: results of the EXPERT-C trial. Eur. J. Cancer 2014 May; 50(8): 1430-6
- Angelini PD, Zacarias Fluck MF, Pedersen K, Parra-Palau JL, Guiu M, Bernadó Morales C, Vicario R, Luque-García A, Navalpotro NP, Giralt J, Canals F, Gomis RR, Tabernero J, Baselga J, Villanueva J, Arribas J. Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence.Cancer Res. 2013 Jan; 73(1): 450-8
- Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T, Verheij M, van den Brekel M, Vogel W, Slevin N, Deutsch E, Sonke JJ, Lambin P, Rasch C. Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer. BMC Cancer 2013; 13: 84
- Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C, Taylor R, Gandola L, Björk-Eriksson T, Giralt J, Oldenburger F, Pietsch T, Figarella-Branger D, Robson K, Forni M, Clifford SC, Warmuth-Metz M, von Hoff K, Faldum A, Mosseri V, Kortmann R. Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial. J. Clin. Oncol. 2012 Sep; 30(26): 3187-93
- Beltran M, Ramos M, Rovira JJ, Perez-Hoyos S, Sancho M, Puertas E, Benavente S, Ginjaume M, Giralt J. Dose variations in tumor volumes and organs at risk during IMRT for head-and-neck cancer. J Appl Clin Med Phys 2012; 13(6): 3723
- Rivera F, Galán M, Tabernero J, Cervantes A, Vega-Villegas ME, Gallego J, Laquente B, Rodríguez E, Carrato A, Escudero P, Massuti B, Alonso-Orduña V, Cardenal A, Sáenz A, Giralt J, Yuste AL, Antón A, Aranda E. Phase II trial of induction irinotecan-cisplatin followed by concurrent irinotecan-cisplatin and radiotherapy for unresectable, locally advanced gastric and oesophageal-gastric junction adenocarcinoma. Cancer Chemother. Pharmacol. 2011 Jan; 67(1): 75-82
- Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010 Jan; 11(1): 21-8
- Peters LJ, O’Sullivan B, Giralt J, Fitzgerald TJ, Trotti A, Bernier J, Bourhis J, Yuen K, Fisher R, Rischin D. Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02. J. Clin. Oncol. 2010 Jun; 28(18): 2996-3001
- Peters LJ, Fitzgerald TJ, Giralt J, O’Sullivan B, Bernier J, Trotti A, Bourhis J, Yuen K, Fisher R, Rischin D. Radiotherapy Protocol Compliance And Quality In The Treatment Of Advanced Head and Neck Cancer – Results From Trog 02.02 J Clin Oncol 2010 jun; 28(18): 2996-3001
- Rivera F, Galán M, Tabernero J, Cervantes A, Vega-Villegas ME, Gallego J, Laquente B, Rodríguez E, Carrato A, Escudero P, Massuti B, Alonso-Orduña V, Cardenal A, Sáenz A, Giralt J, Yuste AL, Antón A, Aranda E. Phase II trial of preoperative irinotecan-cisplatin followed by concurrent irinotecan-cisplatin and radiotherapy for resectable locally advanced gastric and esophagogastric junction adenocarcinoma.Int. J. Radiat. Oncol. Biol. Phys. 2009 Dec; 75(5): 1430-6
- Varela E, Antolín M, Guarner F, Verges R, Giralt J, Malagelada JR. Faecal DNA and calprotectin as biomarkers of acute intestinal toxicity in patients undergoing pelvic radiotherapy. Aliment. Pharmacol. Ther. 2009 Jul; 30(2): 175-85
- Benavente S, Verges R, Hermosilla E, Fumanal V, Casanova N, Garcia A, Ramón y Cajal S, Giralt J. Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2009 Dec; 75(5): 1316-22
- Guarner L, Navalpotro B, Molero X, Giralt J, Malagelada JR. Management of painful chronic pancreatitis with single-dose radiotherapy. Am. J. Gastroenterol. 2009 Feb; 104(2): 349-55
- Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2006 Feb; 354(6): 567-78
- Giralt J, de las Heras M, Cerezo L, Eraso A, Hermosilla E, Velez D, Lujan J, Espín E, Roselló J, Majo J, Benavente S, Armengol M, de Torres I. The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy: a multicenter, retrospective analysis. Radiother Oncol 2005 Feb; 74(2): 101-8
- Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N. Engl. J. Med. 2004 May; 350(19): 1945-52
Funded Projects
- RADGEN-HNC: Radiogenomic profiling and AI-based spatiotemporal modelling for early detection of radiation-induced multi-organ toxicity in patients with head and neck cancer. Principal Investigator: L. Humbert. Duration: 2025-2028.
- GRAPE – 101292396 – GAP-101292396. Gold Radiosensitizers for Advanced Proton thErapy (GRAPE) ERC Proof of Concept Lump Sum Grant 2025 (ERC-2025-PoC). Principal Investigators: Gerard Tobias, Esperanza Medina.
- Assessement of the clinical and biological factors associated with the risk of relapse in localized intermediate and high risk prostate cancer subjected to androgen deprivation and combined radiotherapy. FIS PI24/00527. Principal Investigator: X. Maldonado. Duration: 2024-2027.
- CAT_Clin_ART EU4H_2023_PJ_05:. Organisation of Clinical audit Campaigns as a tool to improve Quality and Safety of medical applications of ionising radiation. Funding entity: EU4Health 2024 Work Programme. European Commission. Team member PI WP4: X. Maldonado. Duration: 2024-2027.
- The role of circulating exosomes as a biomarker for risk stratification and treatment personalization in patients with prostate cancer after radical prostatectomy. Funding entity: IRAD_FEOR funding in cooperation with the Universidad de Navarra. Principal Investigator: X. Maldonado. Duration: 2024-2027.
- EPA (AG) 69/2018 (5413) IRONMAN-ES: Prospective observational study of clinical parameters and biomarkers in advanced prostate cancer in hospitals in Spain. Principal Investigator: J. Mateo. Ongoing.
- ENCANT – 101189443 – GAP-101189443. The ENCANT project, led by Gerard Tobías-Rossell (ICMAB-CSIC), focuses on increasing the effectiveness of cancer radiotherapy through the use of nanoparticles. Principal Investigator: M. Altabas. Duration: 2022-2025.
- RAdiogenomics Biorepository and Databank (RBD) PAR-11-167 Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (UM1). PI: S. Gutiérrez, SI: V. Reyes. Ongoing.
- FIS Detection of ctDNA from breast milk and methylome analysis for early diagnosis of breast cancer associated with pregnancy in high-risk populations: Meth-MMATERNA. SI: V. Reyes. Duration: 2024-2027.
- Deciphering the progression of ductal carcinoma in situ to avoid overtreatment of patients and improve the impact on sexual and reproductive health. Funding entity: TV3-Marato grant :33 / 102 SI: V. Reyes. Duration: 2024-2026.
- Risk assessment Tools for severe side Effects after breasT Radiotherapy: radiation safety through biological extended models and dIgital twinS-TETRIS. Funding Agency: European Commission. 1/10/2024-30/09/2027. SI: V. Reyes. Ref: 101166699.
- UMBRELLA SIOP-RTSG 2016 protocol. Registry of the treatment of all pediatric kidney tumors. Ongoing.
- New therapeutic approaches in head and neck cancer. Funding entity: FIS PI20/556. Co-PI: S. Benavente. Fundació Institut de Recerca de l’Hospital Univ. Vall d’Hebron. Duration: 2021-2023. Extended 2025.
- PIANOFORTE-EMPATHY proton project on assessing dose distribution in adaptive proton therapy. Co-PI: X. Maldonado. Duration: 2024-2027.
- ENCANT – Nanoengineered particles for enhanced cancer radiotherapy. Reference: 101189443. Funded by: European Commission. 1/01/2025-30/08/2026. Principal Investigator: Xavier Maldonado
- EURopeAn MEDical application and Radiation prOteCtion Concept: strategic research agenda aNd ROadmap interLinking to heaLth and digitisation aspects – EURAMED rocc-n-roll. EU Horizon 2020 research and innovation programme. Grant agreement no: 899995
- COGNITO: Evaluation of long-term cognitive effects in childhood cancer survivors. Reference: PR(AMI)389/2017. Principal Investigator: Monica Ramos. EU project 899995 – EURAMED
Non-Funded Projects
- Validation of a biomarker from prostate biopsies based on multimodal artificial intelligence and use of digital pathology. Secondary analysis of phase III clinical trial DART 01/5 TYPE: Research Project (LIB 14/2007) CODE: DART-AI. Co-PI: X. Maldonado. 2025-2026.
- PR(AG)451/2024 Estimation of the risk of developing a second cancer in pediatric patients receiving craniospinal proton beam radiotherapy treatment. Principal Investigator: M. Beltran, SI: Maldonado. 2025-2027.
- QUARTET; program for the quality control of pediatric treatments. It is a program subsidized by the SIOP (International Society of Pediatric Oncology) and with the technical support of the EORTC. Team member: M. Ramos. Duration: 2023-2028.
- EORTC Study 1811 E²-RADIatE: European Radiotherapy Infrastructure of EORTC-ESTRO” Cohort: OligoCare 1822- Pragmatic observational study to evaluate radical radiotherapy in patients with oligo-metastatic cancer. Team member: S. Benavente. Duration: 2024-2029.
- RADIOGENOMICS Biorepository and Databank (RBD) PAR-11-167 Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (UM1). In addition to DNA isolated from blood collected epidemiological data / records of patient outcomes related to the treatment. Co-PI: V. Reyes. Duration: 2022- ongoing.
- EORTC Research Project 2011. E2RADIatE – ReCare. A prospective observational cohort on high-dose re-irradiation. ReCare Consortium Team member: S. Benavente. Duration: 2024-2029.
- Validation of the MD Anderson Toxicity and QoL questionnaires (MDASI) in Head and Neck tumors treated with radiotherapy in the HU Vall d’Hebron. S. Benavente, R. Granado. Duration: 2025-2028.
- CPP BATEA-VHIO-FIDIS-FIHM. Preclinical development and clinical proofof-concept of GlioHook, an implantable medical device for the treatment of glioblastoma. Proyectos de Colaboración Público-Privada. Principal Investigators: F. Martínez Ricarte, M. Vieito, X. Maldonado. Duration: 2025-2028.
- Adaptive radiation therapy based on PET functional imaging for H&N cancer patients.
- Breast irradiation, comparisons and analysis of dose distribution and reproducibility in supine versus prone position.
- Phase II clinical Essay extracranial stereotactic radiotherapy in the treatment of locally advanced prostate cancer.
- Instrumentation radiotherapy of the spine and paraspinal tumors and metastases.
- Extracranial stereotactic radiotherapy in pancreatic cancer, commissioning and validation of the technique.
- Techniques for reducing toxicity: radiotherapy treatment in the pediatric patients with brain tumors.
