Francisco Martínez Jiménez
fmartinez@vhio.net
Current position
- Group Leader of VHIO´s Computational Immunogenomics Group
Academic Qualifications
- 2022 Postdoctoral fellow in cancer immunogenomics at the UMC Utrecht in Utrecht (PI: Edwin Cuppen).
- 2020 Postdoctoral fellow in cancer genomics at the Institute for Biomedical Research (IRB) in Barcelona (PI: Nuria López-Bigas).
- 2016 PhD in Biomedicine by the CNAG/CRG and Universitat Pompeu Fabra (supervisor Marc A.Martí-Renom).
- 2015 MSc in Pharmaceutical Industry and Biotechnology by the Universitat Pompeu Fabra.
- 2012 MSc in Computational Biology by the Universidad Complutense de Madrid.
- 2011 Degree in Computer Engineering by the Universidad Complutense de Madrid.
Areas of Research
- Tumor evolution and immune system interplay
- Development of patient tailored immunotherapies
- Differences between primary and metastatic tumors
- Implementation of WGS for cancer routine care
Prizes and Scholarships
- 2021, Premi Ciutat de Barcelona 2021, Life Sciences category (Article: In-silico saturation of cancer genes)
- 2021, Finalist of the best scientific article award from the Societat Catalana de Biologia (Article: Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer)
- 2020, MSKCC Emerging Leader in Computational Oncology award
- 2016, PhD with excellent cum laude in Biomedicine
Most relevant scientific publications
- Francisco Martínez-Jiménez*, Ali Movasati, Sascha Brunner, Luan Nguyen, Peter Priestley, Edwin Cuppen, Arne Van Hoeck. Pan-cancer whole genome comparison of primary and metastatic solid tumors. bioRxiv 2022.06.17.496528; doi: https://doi.org/10.1101/2022.06.17.496528
- Francisco Martínez-Jiménez*+, Peter Priestley*, Charles Shale, Jonathan Baber, Erik Rozemuller, Edwin Cuppen+. Genetic immune escape landscape in primary and metastatic cancer. bioRxiv 2022.02.23.481444; doi: https://doi.org/10.1101/2022.02.23.481444
- Muiños F*, Martínez-Jiménez F*, Pich O, Gonzalez-Perez A, Lopez-Bigas N. In-silico saturation mutagenesis of cancer genes. Nature. 2021 Aug;596(7872):428-432. doi: 10.1038/s41586-021-03771-1
- Martínez-Jiménez F*, Muiños F, Sentís I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, Mularoni L, Pich O, Bonet J, Kranas H, Gonzalez-Perez A, Lopez-Bigas N. A compendium of mutational cancer driver genes. Nature Rev Cancer. 2020 Oct;20(10):555-572. doi: 10.1038/s41568-020-0290-x
- Martínez-Jiménez F*, Muiños F, López-Arribillaga E, Lopez-Bigas N, Gonzalez-Perez A. Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer. Nature Cancer. 2020 Jan;1(1):122-135. doi: 10.1038/s43018-019-0001-2
- Martínez-Jiménez F*, Overington JP, Al-Lazikani B, Marti-Renom MA. Rational design of non-resistant targeted cancer therapies. Sci Rep. 2017 Apr 24;7:46632. doi: 10.1038/srep46632.
- Martínez-Jiménez F*, Marti-Renom MA. Ligand-target prediction by structural network biology using nAnnoLyze. PLoS Comput Biol. 2015 Mar 27;11(3):e1004157. doi: 10.1371/journal.pcbi.1004157
- Martínez-Jiménez F*, Papadatos G, Yang L, Wallace IM, Kumar V, Pieper U, Sali A, Brown JR, Overington JP, Marti-Renom MA. Target prediction for an open access set of compounds active against Mycobacterium tuberculosis. PLoS Comput Biol. 2013;9(10):e1003253. doi: 10.1371/journal.pcbi.1003253.For a full list of publications see (https://scholar.google.es/citations?user=LsbPuDwAAAAJ)
