Biosketch Paolo G. Nuciforo

Paolo G. Nuciforo

pnuciforo@vhio.net

Current position

Group Leader of VHIO´s Molecular Oncology Group

Academic Qualifications

1997 Degree in Medicine and Surgery from the University of Catania (Italy)
2002 Board certification in Pathology from the University of Milan (Italy)
2016, PhD Surgery and Morphological Sciences, UAB.

Areas of Research

Discovery and validation of novel biomarkers using tissue-based technologies.
Application of molecular pathology strategies to support early clinical drug development programs.
Multiplexed immunohistochemistry and digital image analysis for high-resolution, single cell, tissue biomarker contexture analyses.
Study tumor-associated microbiota and spatial interactions between bacteria, tumor cells, and immune cells in the tumor microenvironment.

Prizes and Scholarships

2003 winner of the “Alberto Azzarelli” prize for the best research work on soft tissue neoplasm
2005 winner of the AIRC fellowship

Projects

FUSOMAP: Development of microbiota-based diagnostic and prognostic models by mapping intratumoral Fusobacterium and associated gut microbiota in early-stage colorectal cancer – Mutua Madrileña and ISCIII.
Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions – COLOSSUS, H2020.
Opportunity: To Investigate the Microbiome’s Impact on Science and Treatment In Colorectal Cancer – OPTIMISTICC, Grand Challenge, Cancer Research UK.
Microbiota composition as risk predictor in cancer patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – La Marató TV3, 2021.

Most relevant scientific publications

Borgognone A, Serna G, Noguera-Julian M, Alonso L, Parera M, Català-Moll F, Sanchez L, Fasani R, Paredes R, Nuciforo P. Performance of 16S Metagenomic Profiling in Formalin-Fixed Paraffin-Embedded versus Fresh-Frozen Colorectal Cancer Tissues. Cancers (Basel). 2021 Oct 29;13(21):5421.
Griguolo G, Serna G, Pascual T, Fasani R, Guardia X, Chic N, Paré L, Pernas S, Muñoz M, Oliveira M, Vidal M, Llombart-Cussac A, Cortés J, Galván P, Bermejo B, Martínez N, López R, Morales S, Garau I, Manso L, Alarcón J, Martínez E, Villagrasa P, Prat A, Nuciforo P. Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. NPJ Precis Oncol. 2021 Mar 19;5(1):23.
Oliva M, Mulet-Margalef N, Ochoa-De-Olza M, Napoli S, Mas J, Laquente B, Alemany L, Duell EJ, Nuciforo P, Moreno V. Tumor-Associated Microbiome: Where Do We Stand? Int J Mol Sci. 2021 Feb 1;22(3):1446.
Cribiù FM, Erra R, Pugni L, Rubio-Perez C, Alonso L, Simonetti S, Croci GA, Serna G, Ronchi A, Pietrasanta C, Lunghi G, Fagnani AM, Piñana M, Matter M, Tzankov A, Terracciano L, Anton A, Ferrazzi E, Ferrero S, Iurlaro E, Seoane J, Nuciforo P. Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission. J Clin Invest. 2021 Mar 15;131(6):e145427.
Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. Griguolo G, Serna G, Pascual T, Fasani R, Guardia X, Chic N, Paré L, Pernas S, Muñoz M, Oliveira M, Vidal M, Llombart-Cussac A, Cortés J, Galván P, Bermejo B, Martínez N, López R, Morales S, Garau I, Manso L, Alarcón J, Martínez E, Villagrasa P, Prat A, Nuciforo P.NPJ Precis Oncol. 2021 Mar 19;5(1):23. doi: 10.1038/s41698-021-00163-6.
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission. Cribiù FM, Erra R, Pugni L, Rubio-Perez C, Alonso L, Simonetti S, Croci GA, Serna G, Ronchi A, Pietrasanta C, Lunghi G, Fagnani AM, Piñana M, Matter M, Tzankov A, Terracciano L, Anton A, Ferrazzi E, Ferrero S, Iurlaro E, Seoane J, Nuciforo P.J Clin Invest. 2021 Mar 15;131(6):e145427. doi: 10.1172/JCI145427.
Serna G, Ruiz-Pace F, Hernando J, Alonso L, Fasani R, Landolfi S, Comas R, Jimenez J, Elez E, Bullman S, Tabernero J, Capdevila J, Dienstmann R, Nuciforo P. Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer. Ann Oncol. 2020 Oct;31(10):1366-1375.
Serna G, Simonetti S, Fasani R, Pagliuca F, Guardia X, Gallego P, Jimenez J, Peg V, Saura C, Eppenberger-Castori S, Ramon Y Cajal S, Terracciano L, Nuciforo P. Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer. Breast. 2020 Oct;53:102-110.
Dienstmann R, Garralda E, Aguilar S, Sala G, Viaplana C, Ruiz-Pace F, González- Zorelle J, Grazia LoGiacco D, Ogbah Z, Ramos Masdeu L, Mancuso F, Fasani R, Jimenez J, Martinez P, Oaknin A, Saura C, Oliveira M, Balmaña J, Carles J, Macarulla T, Elez E, Alsina M, Braña I, Felip E, Tabernero J, Rodon J, Nuciforo P, Vivancos A. Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials. JCO Precis Oncol. 2020 May 14;4:PO.19.00398.
Serna G, Ruiz-Pace F, Cecchi F, Fasani R, Jimenez J, Thyparambil S, Landolfi S, Elez E, Vivancos A, Hembrough T, Tabernero J, Dienstmann R, Nuciforo P. Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer. Sci Rep. 2019 Sep 19;9(1):13568.
Saura C, Hlauschek D, Oliveira M, Zardavas D, Jallitsch-Halper A, de la Peña L, Nuciforo P, Ballestrero A, Dubsky P, Lombard JM, Vuylsteke P, Castaneda CA, Colleoni M, Santos Borges G, Ciruelos E, Fornier M, Boer K, Bardia A, Wilson TR, Stout TJ, Hsu JY, Shi Y, Piccart M, Gnant M, Baselga J, de Azambuja E. Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol. 2019 Sep;20(9):1226-1238. doi: 10.1016/S1470-2045(19)30334-1.
Oliveira M, Saura C, Nuciforo P, Calvo I, Andersen J, Passos-Coelho JL, Gil Gil M, Bermejo B, Patt DA, Ciruelos E, de la Peña L, Xu N, Wongchenko M, Shi Z, Singel SM, Isakoff SJ. FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer. Ann Oncol. 2019 Aug 1;30(8):1289-1297.
Nuciforo P, Thyparambil S, Aura C, Garrido-Castro A, Vilaro M, Peg V, Jimenez J, Vicario R, Cecchi F, Hoos W, Burrows J, Hembrough T, Ferreres JC, Perez-Garcia J, Arribas J, Cortes J, Scaltriti M. High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy. Mol Oncol. 2016;10(1):138-147.
Prat A, Galván P, Jiménez B, Buckingham W, Jeiranian HA, Schaper C, Vidal M, Alvarez M, Díaz S, Ellis C, Nuciforo P, Ferree S, Ribelles N, Adamo B, Ramón y Cajal S, Peg V, Alba E. Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay.Clin. Cancer Res. 2016 Feb; 22(3): 560-6
Arqués O, Chicote I, Puig I, Tenbaum SP, Argiles G, Dienstmann R, Fernández N, Caratù G, Matito J, Silberschmidt D, Rodón J, Landolfi S, Prat A, Espín E, Charco R, Nuciforo P, Vivancos A, Shao W, Tabernero J, Pálmer HG. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. Clin. Cancer Res. 2016 Feb; 22(3): 644-56
Scaltriti M, Nuciforo P, Bradbury I, Sperinde J, Agbor-Tarh D, Campbell C, Chenna A, Winslow J, Serra V, Parra JL, Prudkin L, Jimenez J, Aura C, Harbeck N, Pusztai L, Ellis C, Eidtmann H, Arribas J, Cortes J, de Azambuja E, Piccart M, Baselga J. High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Clin. Cancer Res. 2015 Feb; 21(3): 569-76
Prudkin L, Nuciforo P. Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic. Cell Oncol (Dordr) 2015 Feb; 38(1): 39-48
García-García C, Rivas MA, Ibrahim YH, Calvo MT, Gris-Oliver A, Rodriguez O, Grueso J, Anton P, Guzman M, Aura C, Nuciforo P, Jessen K, Argiles G, Dienstmann R, Bertotti A, Trusolino L, Matito J, Vivancos A, Chicote I, Pálmer HG, Tabernero J, Scaltriti M, Baselga J, Serra V. MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. Clin. Cancer Res. 2015 Dec; 21(24): 5499-510
Vicario R, Peg V, Morancho B, Zacarias-Fluck M, Zhang J, Martínez-Barriocanal Á, Navarro Jiménez A, Aura C, Burgues O, Lluch A, Cortes J, Nuciforo P, Rubio IT, Marangoni E, Deeds J, Boehm M, Schlegel R, Tabernero J, Mosher R, Arribas J. Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies. PLoS ONE 2015; 10(6): e0129876
Salgado R, Denkert C, Campbell C, Savas P, Nuciforo P, Nucifero P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart MJ, Michiels S, Bradbury I, Sotiriou C, Loi S. Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial. JAMA Oncol 2015 Jul; 1(4): 448-54
Herrero A, Pinto A, Colón-Bolea P, Casar B, Jones M, Agudo-Ibáñez L, Vidal R, Tenbaum SP, Nuciforo P, Valdizán EM, Horváth Z, Orfi L, Pineda-Lucena A, Bony E, Keri G, Rivas G, Pazos A, Gozalbes R, Pálmer HG, Hurlstone A, Crespo P. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 2015 Aug; 28(2): 170-82
Nuciforo P, Radosevic-Robin N, Ng T, Scaltriti M. Quantification of HER family receptors in breast cancer. Breast Cancer Res. 2015; 17: 53Nuciforo P, Thyparambil S, Aura C, Garrido-Castro A, Vilaro M, Peg V, Jimenez J, Vicario R, Cecchi F, Hoos W, Burrows J, Hembrough T, Ferreres JC, Perez-Garcia J, Arribas J, Cortes J, Scaltriti M. High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy. Mol Oncol. 2016;10(1):138-147. Epub 2015 Sep 15.
Salgado R, Denkert C, Campbell C, Savas P, Nuciforo P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart MJ, Michiels S, Bradbury I, Sotiriou C, Loi S. Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial. JAMA Oncol. 2015;1(4):448-454. Erratum in: JAMA Oncol. 2015;1(8):1172.
Nuciforo P, Radosevic-Robin N, Ng T, Scaltriti M. Quantification of HER family receptors in breast cancer. Breast Cancer Res. 2015;17:53.
Nuciforo PG, Aura C, Holmes E, Prudkin L, Jimenez J, Martinez P, Ameels H, de la Peña L, Ellis C, Eidtmann H, Piccart-Gebhart MJ, Scaltriti M, Baselga J. Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status. Ann Oncol. 2015;26(7):1494-1500.

All publications

Chic, Nuria ; Luen, Stephen J ; NUCIFORO, PAOLO GIOVANNI; Salgado, Roberto ; Fumagalli, Debora ; Hilbers, Florentine ; Wang, Yingbo ; de Azambuja, Evandro ; Làng, István ; DI COSIMO, SERENA; SAURA MANICH, CRISTINA; Huober, Jens ; PRAT APARICIO, ALEIX; Loi, Sherene. Tumor Cellularity and Infiltrating Lymphocytes (CelTIL) as a Survival Surrogate in HER2-Positive Breast Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE.1093/jnci/djab057
Frigola, Joan; NAVARRO MENDIVIL, ALEJANDRO; Carbonell, Caterina ; Callejo, Ana ; Iranzo, Patricia ; CEDRES PEREZ, SUSANA; MARTINEZ MARTI, ALEXANDRE; PARDO ARANDA, NURIA; Saoudi-Gonzalez, Nadia ; Martinez, Debora ; JIMENEZ, JOSE; Sansano, Irene ; MANCUSO, FRANCESCO MATTIA; NUCIFORO, PAOLO GIOVANNI; Montuenga, Luis M ; Sánchez-Cespedes, Montse ; PRAT APARICIO, ALEIX; VIVANCOS PRELLEZO, ANA; FELIP FONT, ENRIQUETA; AMAT FERRER, RAMON. Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer. MOLECULAR ONCOLOGY. 2021 April. 10.1002/1878-0261.12891
LIGERO HERNANDEZ, MARTA; Garcia-Ruiz, Alonso ; VIAPLANA DONATO, CRISTINA; VILLACAMPA JAVIERRE, GUILLERMO; Raciti, Maria V ; Landa, Jaid ; MATOS GARCIA, IGNACIO; MARTIN LIBERAL, JUAN JESUS; OCHOA DE OLZA AMAT, MARIA; HIERRO CARBO, CINTA; MATEO VALDERRAMA, JOAQUIN; Gonzalez, Macarena ; MORALES BARRERA, RAFAEL; SUAREZ RODRIGUEZ, CRISTINA; RODON AHNERT, JORDI; ELEZ FERNANDEZ, MARIA ELENA; BRAÑA GARCIA, IRENE; MUÑOZ COUSELO, EVA; OAKNIN BENZAQUEN, ANA MAZALTOB; FASANI, ROBERTA; NUCIFORO, PAOLO GIOVANNI; Gil, Debora ; RUBIO, ISABEL TERESA; SEOANE SUAREZ, JOAN; FELIP FONT, ENRIQUETA; Escobar, Manuel ; TABERNERO CATURLA, JOSEP; CARLES GALCERAN, JOAN; DIENSTMANN, RODRIGO; GARRALDA CABANAS, ELENA; PEREZ LOPEZ, RAQUEL. A CT-based Radiomics Signature Is Associated with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors. Radiology. 2021 April. 10.1148/radiol.2021200928
RUBIO PEREZ, CARLOTA; Planas-Rigol, Ester ; Trincado, Juan L ; BONFILL TEIXIDOR, ESTER; ARIAS PIÑEIRO, ALEXANDRA; Marchese, Domenica ; Moutinho, Catia ; SERNA ALONSO, GARAZI; Pedrosa, Leire ; IURLARO, RAFFAELLA; Martínez-Ricarte, Francisco ; ESCUDERO MONREAL, LAURA; Cordero, Esteban ; Cicuendez, Marta ; Ruiz, Sara ; Parra, Genís ; NUCIFORO, PAOLO GIOVANNI; Gonzalez, Josep ; Pineda, Estela ; Sahuquillo, Juan ; TABERNERO CATURLA, JOSEP; Heyn, Holger ; SEOANE SUAREZ, JOAN. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. NATURE COMMUNICATIONS. 2020 March. 10.1038/s41467-021-21789-x
Oliva, Marc ; MULET MARGALEF, NURIA; OCHOA DE OLZA AMAT, MARIA; Napoli, Stefania ; Mas, Joan ; Laquente, Berta ; Alemany, Laia ; Duell, Eric J ; NUCIFORO, PAOLO GIOVANNI; Moreno, Victor. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Tumor-Associated Microbiome: Where Do We Stand?. 2021 February. 10.3390/ijms22031446
Hudecek, J. ; Voorwerk, L. ; van Seijen, M. ; Nederlof, I. ; de Maaker, M. ; van den Berg, J. ; van de Vijver, K.K. ; Sikorska, K. ; Adams, S. ; Demaria, S. ; Viale, G. ; Nielsen, T.O. ; Badve, S.S. ; Michiels, S. ; Symmans, W.F. ; Sotiriou, C. ; Rimm, D.L. ; Hewitt, S.M. ; Denkert, C. ; Loibl, S. ; Loi, S. ; Bartlett, J.M.S. ; Pruneri, G. ; Dillon, D.A. ; Cheang, M.C.U. ; Tutt, A. ; Hall, J.A. ; Kos, Z. ; Salgado, R. ; Kok, M. ; Horlings, H.M. ; Hyytiäinen, A. ; Hida, A.I. ; Thompson, A. ; Lefevre, A. ; Lazar, A.J. ; Gown, A. ; Lo, A. ; Sapino, A. ; Madabhushi, A. ; Moreira, A. ; Richardson, A. ; Vingiani, A. ; Beck, A.H. ; Bellizzi, A.M. ; Guerrero, A. ; Grigoriadis, A. ; Ehinger, A. ; Garrido-Castro, A. ; Vincent-Salomon, A. ; Laenkholm, A.-V. ; Sharma, A. ; Cimino-Mathews, A. ; Srinivasan, A. ; Acs, B. ; Singh, B. ; Calhoun, B. ; Haibe-Kans, B. ; Solomon, B. ; Thapa, B. ; Nelson, B.H. ; Gallas, B.D. ; Castaneda, C. ; Ballesteros-Merino, C. ; Criscitiello, C. ; Boeckx, C. ; Colpaert, C. ; Quinn, C. ; Chennubhotla, C.S. ; Swanton, C. ; Solinas, C. ; Hiley, C. ; Drubay, D. ; Bethmann, D. ; Moore, D.A. ; Larsimont, D. ; Sabanathan, D. ; Peeters, D. ; Zardavas, D. ; Höflmayer, D. ; Johnson, D.B. ; Thompson, E.A. ; Brogi, E. ; Perez, E. ; ElGabry, E.A. ; Stovgaard, E.S. ; Blackley, E.F. ; Roblin, E. ; Reisenbichler, E. ; Bellolio, E. ; Balslev, E. ; Chmielik, E. ; Gaire, F. ; Andre, F. ; Lu, F.-I. ; Azmoudeh-Ardalan, F. ; Rojo, F. ; Gruosso, T. ; Ciompi, F. ; Peale, F. ; Hirsch, F.R. ; Klauschen, F. ; Penault-Llorca, F. ; Acosta Haab, G. ; Farshid, G. ; van den Eynden, G. ; Curigliano, G. ; Floris, G. ; Broeckx, G. ; Gonzalez-Ericsson ; Koeppen, H. ; Haynes, H.R. ; McArthur, H. ; Joensuu, H. ; Olofsson, H. ; Lien, H.-C. ; Chen, I.-C. ; Cree, I. ; Frahm, I. ; Brcic, I. ; Chan, J. ; Ziai, J. ; Brock, J. ; Wesseling, J. ; Giltnane, J. ; Kerner, J.K. ; Thagaard, J. ; Braybrooke, J.P. ; van der Laak, J.A.W.M. ; Lemonnier, J. ; Zha, J. ; Ribeiro, J. ; Lennerz, J.K. ; Carter, J.M. ; Saltz, J. ; Hartman, J. ; Hainfellner, J. ; Quesne, J.L. ; Juco, J.W. ; Reis-Filho, J. ; Sanchez, J. ; Sparano, J. ; Cucherousset, J. ; Araya, J.C. ; Adam, J. ; Balko, J.M. ; Saeger, K. ; Siziopikou, K. ; Willard-Gallo, K. ; Weber, K. ; Pogue-Geile, K.L. ; Steele, K.E. ; Emancipator, K. ; AbdulJabbar, K. ; El Bairi, K. ; Blenman, K.R.M. ; Allison, K.H. ; Korski, K. ; Pusztai, L. ; Comerma, L. ; Buisseret, L. ; Cooper, L.A.D. ; Shi, L. ; Kooreman, L.F.S. ; Molinero, L. ; Estrada, M.V. ; Lacroix-Triki, M. ; Al Bakir, M. ; Sebastian, M.M. ; van de Vijver, M. ; Balancin, M.L. ; Dieci, M.V. ; Mathieu, M.-C. ; Rebelatto, M.C. ; Piccart, M. ; Hanna, M.G. ; Goetz, M.P. ; Preusser, M. ; Khojasteh, M. ; Sanders, M.E. ; Regan, M.M. ; Barnes, M. ; Christie, M. ; Misialek, M. ; Ignatiadis, M. ; van Bockstal, M. ; Castillo, M. ; Amgad, M. ; Harbeck, N. ; Tung, N. ; Laudus, N. ; Sirtaine, N. ; Burchardi, N. ; Ternes, N. ; Radosevic-Robin, N. ; Gluz, O. ; Grimm, O. ; NUCIFORO, PAOLO GIOVANNI; Jank, P. ; Gonzalez-Ericsson, P. ; Kirtani, P. ; Jelinic, P. ; Watson, P.H. ; Savas, P. ; Francis, P.A. ; Russell, P.A. ; Singh, R. ; Kim, R.S. ; Pierce, R.H. ; Hills, R. ; Leon-Ferre, R. ; de Wind, R. ; Shui, R. ; De Clercq, S. ; Leung, S. ; Tabbarah, S. ; Souza, S.C. ; O’Toole, S. ; Swain, S. ; Dudgeon, S. ; Willis, S. ; Ely, S. ; Kim, S.-R. ; Bedri, S. ; Irshad, S. ; Liu, S.-W. ; Goel, S. ; Hendry, S. ; Bianchi, S. ; Bragança, S. ; Paik, S. ; Wienert, S. ; Fox, S.B. ; Luen, S.J. ; Naber, S. ; Schnitt, S.J. ; Sua, L.F. ; Lakhani, S.R. ; Fineberg, S. ; Soler, T. ; Gevaert, T. ; D’Alfonso, T. ; John, T. ; Sugie, T. ; Kurkure, U. ; Bossuyt, V. ; Manem, V. ; Cámara, V.P. ; Tong, W. ; Chen, W. ; Yang, W. ; Tran, W.T. ; Wang, Y. ; Yuan, Y. ; Allory, Y. ; Husain, Z. ; Bago-Horvath, Z. Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials. NPJ breast cancer. 2020 January. 10.1038/s41523-020-0155-1
Chic, Nuria ; Luen, Stephen J ; NUCIFORO, PAOLO GIOVANNI; Salgado, Roberto ; Fumagalli, Debora ; Hilbers, Florentine ; Wang, Yingbo ; de Azambuja, Evandro ; Làng, István ; DI COSIMO, SERENA; SAURA MANICH, CRISTINA; Huober, Jens ; PRAT APARICIO, ALEIX; Loi, Sherene. HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2020 January. 10.1093/jnci/djz042
CAPDEVILA CASTILLON, JAUME; MATOS GARCIA, IGNACIO; MANCUSO, FRANCESCO MATTIA; Iglesias, Carmela; NUCIFORO, PAOLO GIOVANNI; Zafon, Carles ; GARCIA PALMER, HECTOR; OGBAH, ZIGHEREDA; Muinos, Laura ; HERNANDO CUBERO, JORGE; Villacampa, Guillermo ; Peña, Carol E ; TABERNERO CATURLA, JOSEP; Brose, Marcia S ; Schlumberger, Martin ; VIVANCOS PRELLEZO, ANA. Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial. MOLECULAR CANCER THERAPEUTICS. 2020 January. 10.1158/1535-7163.MCT-19-0211
Cebrià-Costa, J P ; PASCUAL REGUANT, LAURA; Gonzalez-Perez, A ; Serra-Bardenys, G ; QUEROL PAÑOL, JESSICA; Cosín, M ; Verde, G ; Cigliano, R A ; Sanseverino, W ; Segura-Bayona, S ; Iturbide, A ; Andreu, D ; NUCIFORO, PAOLO GIOVANNI; Bernado-Morales, C ; RODILLA BENITO, VERONICA; ARRIBAS LOPEZ, JOAQUIN VICENTE; Yelamos, J ; de Herreros, A Garcia ; Stracker, T H ; PEIRO SALES, SANDRA. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. 2020 January. 10.1038/s41388-019-0969-1
NUCIFORO, PAOLO GIOVANNI; Townend, J. ; SAURA MANICH, CRISTINA; de Azumbaja, E. ; Hilbers, F. ; Manukyants, A. ; Werutsky, G. ; Bliss, J. ; Moebus, V. ; Colleoni, M. ; Aspitia, A.M. ; Di Cosimo, S. ; Van dooren, V. ; Kroep, J. ; Ferro, A. ; Cameron, D. ; Gelber, R. ; Piccart-Gebhart, M. ; Huober, J. Nine-year survival outcome of neoadjuvant lapatinib with trastuzumab for HER2-positive breast cancer (NeoALTTO, BIG 1-06): final analysis of a multicentre, open-label, phase 3 randomised clinical trial. EUROPEAN JOURNAL OF CANCER. 2020 January. 10.1016/S0959-8049(20)30560-8
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GARCIA VALVERDE, LUIS ALFONSO; Rosell, Jordi; Serna, Garazi ; VALVERDE MORALES, CLAUDIA M; CARLES GALCERAN, JOAN; NUCIFORO, PAOLO GIOVANNI; Fletcher, Jonathan A ; ARRIBAS LOPEZ, JOAQUIN VICENTE; Politz, Oliver ; SERRANO GARCIA, CESAR. Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor. MOLECULAR CANCER THERAPEUTICS. 2020 June. 1158/1535-7163.MCT-19-1069
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GRIS OLIVER, ALBERT; PALAFOX SANCHEZ, MARTA; MONTSERRAT VICENTE, LAIA; Brasó-Maristany, Fara ; Òdena, Andreu ; SANCHEZ GUIXE, MONICA; IBRAHIM, YASIR HUSSEIN; VILLACAMPA JAVIERRE, GUILLERMO; GRUESO GRAGERA, JUDIT; Parés, Mireia ; GUZMAN, MARTA; RODRIGUEZ FERREIRO, OLGA; Bruna, Alejandra ; Hirst, Caroline S ; Barnicle, Alan ; de Bruin, Elza C ; Reddy, Avinash ; Schiavon, Gaia ; ARRIBAS LOPEZ, JOAQUIN VICENTE; Mills, Gordon B ; Caldas, Carlos ; Dienstman, Rodrigo ; PRAT APARICIO, ALEIX; NUCIFORO, PAOLO GIOVANNI; Razavi, Pedram ; SCALTRITI, MAURIZIO; Turner, Nicholas C ; SAURA MANICH, CRISTINA; Davies, Barry R ; Oliveira, Mafalda ; SERRA ELIZALDE, VIOLETA. Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. CLINICAL CANCER RESEARCH. 1158/1078-0432.CCR-19-3324
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Zunder, Stéphanie M ; PEREZ LOPEZ, RAQUEL; de Kok, Bente M ; Raciti, Maria Vittoria ; van Pelt, Gabi W ; DIENSTMANN, RODRIGO; Garcia-Ruiz, Alonso ; Meijer, C Arnoud ; Gelderblom, Hans ; Tollenaar, Rob A ; NUCIFORO, PAOLO GIOVANNI; Wasser, Martin N ; Mesker, Wilma E. Correlation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer. EUROPEAN JOURNAL OF RADIOLOGY. 2020 December. 10.1016/j.ejrad.2020.109345
Prat A, Galván P, Jiménez B, Buckingham W, Jeiranian HA, Schaper C, Vidal M, Alvarez M, Díaz S, Ellis C, Nuciforo P, Ferree S, Ribelles N, Adamo B, Ramón y Cajal S, Peg V, Alba E. Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay.Clin. Cancer Res. 2016 Feb; 22(3): 560-6
Arqués O, Chicote I, Puig I, Tenbaum SP, Argiles G, Dienstmann R, Fernández N, Caratù G, Matito J, Silberschmidt D, Rodón J, Landolfi S, Prat A, Espín E, Charco R, Nuciforo P, Vivancos A, Shao W, Tabernero J, Pálmer HG. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. Clin. Cancer Res. 2016 Feb; 22(3): 644-56
Scaltriti M, Nuciforo P, Bradbury I, Sperinde J, Agbor-Tarh D, Campbell C, Chenna A, Winslow J, Serra V, Parra JL, Prudkin L, Jimenez J, Aura C, Harbeck N, Pusztai L, Ellis C, Eidtmann H, Arribas J, Cortes J, de Azambuja E, Piccart M, Baselga J. High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Clin. Cancer Res. 2015 Feb; 21(3): 569-76
Prudkin L, Nuciforo P. Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic. Cell Oncol (Dordr) 2015 Feb; 38(1): 39-48
García-García C, Rivas MA, Ibrahim YH, Calvo MT, Gris-Oliver A, Rodriguez O, Grueso J, Anton P, Guzman M, Aura C, Nuciforo P, Jessen K, Argiles G, Dienstmann R, Bertotti A, Trusolino L, Matito J, Vivancos A, Chicote I, Pálmer HG, Tabernero J, Scaltriti M, Baselga J, Serra V. MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. Clin. Cancer Res. 2015 Dec; 21(24): 5499-510
Vicario R, Peg V, Morancho B, Zacarias-Fluck M, Zhang J, Martínez-Barriocanal Á, Navarro Jiménez A, Aura C, Burgues O, Lluch A, Cortes J, Nuciforo P, Rubio IT, Marangoni E, Deeds J, Boehm M, Schlegel R, Tabernero J, Mosher R, Arribas J. Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies. PLoS ONE 2015; 10(6): e0129876
Salgado R, Denkert C, Campbell C, Savas P, Nuciforo P, Nucifero P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart MJ, Michiels S, Bradbury I, Sotiriou C, Loi S. Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial. JAMA Oncol 2015 Jul; 1(4): 448-54
Herrero A, Pinto A, Colón-Bolea P, Casar B, Jones M, Agudo-Ibáñez L, Vidal R, Tenbaum SP, Nuciforo P, Valdizán EM, Horváth Z, Orfi L, Pineda-Lucena A, Bony E, Keri G, Rivas G, Pazos A, Gozalbes R, Pálmer HG, Hurlstone A, Crespo P. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 2015 Aug; 28(2): 170-82
Nuciforo P, Radosevic-Robin N, Ng T, Scaltriti M. Quantification of HER family receptors in breast cancer. Breast Cancer Res. 2015; 17: 53
Prat A, Adamo B, Fan C, Peg V, Vidal M, Galván P, Vivancos A, Nuciforo P, Pálmer HG, Dawood S, Rodón J, Cajal SR, Campo JM, Felip E, Tabernero J, Cortes J. ERRATUM: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity. Sci Rep 2015; 5: 8179
Majewski IJ, Nuciforo P, Mittempergher L, Bosma AJ, Eidtmann H, Holmes E, Sotiriou C, Fumagalli D, Jimenez J, Aura C, Prudkin L, Díaz-Delgado MC, de La Peña L, Loi S, Ellis C, Schultz N, de Azambuja E, Harbeck N, Piccart-Gebhart M, Bernards R, Baselga J. PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer. J. Clin. Oncol. 2015 Apr; 33(12): 1334-9
De Mattos-Arruda L, Bidard FC, Won HH, Cortes J, Ng CK, Peg V, Nuciforo P, Jungbluth AA, Weigelt B, Berger MF, Seoane J, Reis-Filho JS. Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing. Mol Oncol 2014 Feb; 8(1): 150-8
Dienstmann R, Rodón J, Prat A, Pérez-García J, Adamo B, Felip E, Cortes J, Iafrate AJ, Nuciforo P, Tabernero J. Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Ann. Oncol. 2014 Mar; 25(3): 552-63
Parra-Palau JL, Morancho B, Peg V, Escorihuela M, Scaltriti M, Vicario R, Zacarias-Fluck M, Pedersen K, Pandiella A, Nuciforo P, Serra V, Cortes J, Baselga J, Perou CM, Prat A, Rubio IT, Arribas J. Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy. J. Natl. Cancer Inst. 2014 Nov; 106(11)
De Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CK, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V, Piscuoglio S, Oliveira M, Smolders Y, Patel P, Norton L, Tabernero J, Berger MF, Seoane J, Reis-Filho JS. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle. Ann. Oncol. 2014 Sep; 25(9): 1729-35
Prat A, Adamo B, Fan C, Peg V, Vidal M, Galván P, Vivancos A, Nuciforo P, Pálmer HG, Dawood S, Rodón J, Cajal SR, Ramón y Cajal S, del Campo JM, Ramony Cajal S, Felip E, Tabernero J, Cortes J. Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity. Sci Rep 2013; 3: 3544
Belloni B, Lambertini C, Nuciforo P, Phillips J, Bruening E, Wong S, Dummer R. Will PAXgene substitute formalin? A morphological and molecular comparative study using a new fixative system. J. Clin. Pathol. 2013 Feb; 66(2): 124-35
Serra V, Vivancos A, Puente XS, Felip E, Silberschmidt D, Caratù G, Parra JL, De Mattos-Arruda L, Grueso J, Hernandez-Losa J, Arribas J, Prudkin L, Nuciforo P, Scaltriti M, Seoane J, Baselga J. Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation. Cancer Discov 2013 Nov; 3(11): 1238-44
Lambertini C, Barzaghi-Rinaudo P, D’Amato L, Schulz S, Nuciforo P, Schmid HA. Evaluation of somatostatin receptor subtype expression in human neuroendocrine tumors using two sets of new monoclonal antibodies. Regul. Pept. 2013 Nov; 187: 35-41
Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B, Achsel T, Neri G, Neven P, Evans DG, Carmeliet P, Mazzone M, Bagni C. The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. EMBO Mol Med 2013 Oct; 5(10): 1523-36
Schmid HA, Lambertini C, van Vugt HH, Barzaghi-Rinaudo P, Schäfer J, Hillenbrand R, Sailer AW, Kaufmann M, Nuciforo P. Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors. Neuroendocrinology 2012; 95(3): 232-47
Zipser MC, Eichhoff OM, Widmer DS, Schlegel NC, Schoenewolf NL, Stuart D, Liu W, Gardner H, Smith PD, Nuciforo P, Dummer R, Hoek KS. A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status. Pigment Cell Melanoma Res 2011 Apr; 24(2): 326-33
Luise C, Capra M, Donzelli M, Mazzarol G, Jodice MG, Nuciforo P, Viale G, Di Fiore PP, Confalonieri S. An atlas of altered expression of deubiquitinating enzymes in human cancer. PLoS ONE 2011; 6(1): e15891
Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat. Cell Biol. 2009 Feb; 11(2): 133-42
Raynaud CM, Jang SJ, Nuciforo P, Lantuejoul S, Brambilla E, Mounier N, Olaussen KA, André F, Morat L, Sabatier L, Soria JC. Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. Ann. Oncol. 2008 Nov; 19(11): 1875-81
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