
Paolo G. Nuciforo
pnuciforo@vhio.net
Current position
- Group Leader of VHIO´s Molecular Oncology Group
Academic Qualifications
- 1997 Degree in Medicine and Surgery from the University of Catania (Italy)
- 2002 Board certification in Pathology from the University of Milan (Italy)
- 2016, PhD Surgery and Morphological Sciences, UAB.
Areas of Research
- Discovery and validation of novel biomarkers using tissue-based technologies.
- Application of molecular pathology strategies to support early clinical drug development programs.
- Multiplexed immunohistochemistry and digital image analysis for high-resolution, single cell, tissue biomarker contexture analyses.
- Study tumor-associated microbiota and spatial interactions between bacteria, tumor cells, and immune cells in the tumor microenvironment.
Prizes and Scholarships
- 2003 winner of the “Alberto Azzarelli” prize for the best research work on soft tissue neoplasm
- 2005 winner of the AIRC fellowship
Projects
- FUSOMAP: Development of microbiota-based diagnostic and prognostic models by mapping intratumoral Fusobacterium and associated gut microbiota in early-stage colorectal cancer – Mutua Madrileña and ISCIII.
- Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions – COLOSSUS, H2020.
- Opportunity: To Investigate the Microbiome’s Impact on Science and Treatment In Colorectal Cancer – OPTIMISTICC, Grand Challenge, Cancer Research UK.
- Microbiota composition as risk predictor in cancer patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – La Marató TV3, 2021.
Most relevant scientific publications
- Borgognone A, Serna G, Noguera-Julian M, Alonso L, Parera M, Català-Moll F, Sanchez L, Fasani R, Paredes R, Nuciforo P. Performance of 16S Metagenomic Profiling in Formalin-Fixed Paraffin-Embedded versus Fresh-Frozen Colorectal Cancer Tissues. Cancers (Basel). 2021 Oct 29;13(21):5421.
- Griguolo G, Serna G, Pascual T, Fasani R, Guardia X, Chic N, Paré L, Pernas S, Muñoz M, Oliveira M, Vidal M, Llombart-Cussac A, Cortés J, Galván P, Bermejo B, Martínez N, López R, Morales S, Garau I, Manso L, Alarcón J, Martínez E, Villagrasa P, Prat A, Nuciforo P. Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. NPJ Precis Oncol. 2021 Mar 19;5(1):23.
- Oliva M, Mulet-Margalef N, Ochoa-De-Olza M, Napoli S, Mas J, Laquente B, Alemany L, Duell EJ, Nuciforo P, Moreno V. Tumor-Associated Microbiome: Where Do We Stand? Int J Mol Sci. 2021 Feb 1;22(3):1446.
- Cribiù FM, Erra R, Pugni L, Rubio-Perez C, Alonso L, Simonetti S, Croci GA, Serna G, Ronchi A, Pietrasanta C, Lunghi G, Fagnani AM, Piñana M, Matter M, Tzankov A, Terracciano L, Anton A, Ferrazzi E, Ferrero S, Iurlaro E, Seoane J, Nuciforo P. Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission. J Clin Invest. 2021 Mar 15;131(6):e145427.
- Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. Griguolo G, Serna G, Pascual T, Fasani R, Guardia X, Chic N, Paré L, Pernas S, Muñoz M, Oliveira M, Vidal M, Llombart-Cussac A, Cortés J, Galván P, Bermejo B, Martínez N, López R, Morales S, Garau I, Manso L, Alarcón J, Martínez E, Villagrasa P, Prat A, Nuciforo P.NPJ Precis Oncol. 2021 Mar 19;5(1):23. doi: 10.1038/s41698-021-00163-6.
- Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission. Cribiù FM, Erra R, Pugni L, Rubio-Perez C, Alonso L, Simonetti S, Croci GA, Serna G, Ronchi A, Pietrasanta C, Lunghi G, Fagnani AM, Piñana M, Matter M, Tzankov A, Terracciano L, Anton A, Ferrazzi E, Ferrero S, Iurlaro E, Seoane J, Nuciforo P.J Clin Invest. 2021 Mar 15;131(6):e145427. doi: 10.1172/JCI145427.
- Serna G, Ruiz-Pace F, Hernando J, Alonso L, Fasani R, Landolfi S, Comas R, Jimenez J, Elez E, Bullman S, Tabernero J, Capdevila J, Dienstmann R, Nuciforo P. Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer. Ann Oncol. 2020 Oct;31(10):1366-1375.
- Serna G, Simonetti S, Fasani R, Pagliuca F, Guardia X, Gallego P, Jimenez J, Peg V, Saura C, Eppenberger-Castori S, Ramon Y Cajal S, Terracciano L, Nuciforo P. Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer. Breast. 2020 Oct;53:102-110.
- Dienstmann R, Garralda E, Aguilar S, Sala G, Viaplana C, Ruiz-Pace F, González- Zorelle J, Grazia LoGiacco D, Ogbah Z, Ramos Masdeu L, Mancuso F, Fasani R, Jimenez J, Martinez P, Oaknin A, Saura C, Oliveira M, Balmaña J, Carles J, Macarulla T, Elez E, Alsina M, Braña I, Felip E, Tabernero J, Rodon J, Nuciforo P, Vivancos A. Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials. JCO Precis Oncol. 2020 May 14;4:PO.19.00398.
- Serna G, Ruiz-Pace F, Cecchi F, Fasani R, Jimenez J, Thyparambil S, Landolfi S, Elez E, Vivancos A, Hembrough T, Tabernero J, Dienstmann R, Nuciforo P. Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer. Sci Rep. 2019 Sep 19;9(1):13568.
- Saura C, Hlauschek D, Oliveira M, Zardavas D, Jallitsch-Halper A, de la Peña L, Nuciforo P, Ballestrero A, Dubsky P, Lombard JM, Vuylsteke P, Castaneda CA, Colleoni M, Santos Borges G, Ciruelos E, Fornier M, Boer K, Bardia A, Wilson TR, Stout TJ, Hsu JY, Shi Y, Piccart M, Gnant M, Baselga J, de Azambuja E. Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol. 2019 Sep;20(9):1226-1238. doi: 10.1016/S1470-2045(19)30334-1.
- Oliveira M, Saura C, Nuciforo P, Calvo I, Andersen J, Passos-Coelho JL, Gil Gil M, Bermejo B, Patt DA, Ciruelos E, de la Peña L, Xu N, Wongchenko M, Shi Z, Singel SM, Isakoff SJ. FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer. Ann Oncol. 2019 Aug 1;30(8):1289-1297.
- Nuciforo P, Thyparambil S, Aura C, Garrido-Castro A, Vilaro M, Peg V, Jimenez J, Vicario R, Cecchi F, Hoos W, Burrows J, Hembrough T, Ferreres JC, Perez-Garcia J, Arribas J, Cortes J, Scaltriti M. High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy. Mol Oncol. 2016;10(1):138-147.
- Prat A, Galván P, Jiménez B, Buckingham W, Jeiranian HA, Schaper C, Vidal M, Alvarez M, Díaz S, Ellis C, Nuciforo P, Ferree S, Ribelles N, Adamo B, Ramón y Cajal S, Peg V, Alba E. Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay.Clin. Cancer Res. 2016 Feb; 22(3): 560-6
- Arqués O, Chicote I, Puig I, Tenbaum SP, Argiles G, Dienstmann R, Fernández N, Caratù G, Matito J, Silberschmidt D, Rodón J, Landolfi S, Prat A, Espín E, Charco R, Nuciforo P, Vivancos A, Shao W, Tabernero J, Pálmer HG. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. Clin. Cancer Res. 2016 Feb; 22(3): 644-56
- Scaltriti M, Nuciforo P, Bradbury I, Sperinde J, Agbor-Tarh D, Campbell C, Chenna A, Winslow J, Serra V, Parra JL, Prudkin L, Jimenez J, Aura C, Harbeck N, Pusztai L, Ellis C, Eidtmann H, Arribas J, Cortes J, de Azambuja E, Piccart M, Baselga J. High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Clin. Cancer Res. 2015 Feb; 21(3): 569-76
- Prudkin L, Nuciforo P. Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic. Cell Oncol (Dordr) 2015 Feb; 38(1): 39-48
- García-García C, Rivas MA, Ibrahim YH, Calvo MT, Gris-Oliver A, Rodriguez O, Grueso J, Anton P, Guzman M, Aura C, Nuciforo P, Jessen K, Argiles G, Dienstmann R, Bertotti A, Trusolino L, Matito J, Vivancos A, Chicote I, Pálmer HG, Tabernero J, Scaltriti M, Baselga J, Serra V. MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. Clin. Cancer Res. 2015 Dec; 21(24): 5499-510
- Vicario R, Peg V, Morancho B, Zacarias-Fluck M, Zhang J, Martínez-Barriocanal Á, Navarro Jiménez A, Aura C, Burgues O, Lluch A, Cortes J, Nuciforo P, Rubio IT, Marangoni E, Deeds J, Boehm M, Schlegel R, Tabernero J, Mosher R, Arribas J. Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies. PLoS ONE 2015; 10(6): e0129876
- Salgado R, Denkert C, Campbell C, Savas P, Nuciforo P, Nucifero P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart MJ, Michiels S, Bradbury I, Sotiriou C, Loi S. Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial. JAMA Oncol 2015 Jul; 1(4): 448-54
- Herrero A, Pinto A, Colón-Bolea P, Casar B, Jones M, Agudo-Ibáñez L, Vidal R, Tenbaum SP, Nuciforo P, Valdizán EM, Horváth Z, Orfi L, Pineda-Lucena A, Bony E, Keri G, Rivas G, Pazos A, Gozalbes R, Pálmer HG, Hurlstone A, Crespo P. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 2015 Aug; 28(2): 170-82
- Nuciforo P, Radosevic-Robin N, Ng T, Scaltriti M. Quantification of HER family receptors in breast cancer. Breast Cancer Res. 2015; 17: 53Nuciforo P, Thyparambil S, Aura C, Garrido-Castro A, Vilaro M, Peg V, Jimenez J, Vicario R, Cecchi F, Hoos W, Burrows J, Hembrough T, Ferreres JC, Perez-Garcia J, Arribas J, Cortes J, Scaltriti M. High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy. Mol Oncol. 2016;10(1):138-147. Epub 2015 Sep 15.
- Salgado R, Denkert C, Campbell C, Savas P, Nuciforo P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart MJ, Michiels S, Bradbury I, Sotiriou C, Loi S. Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial. JAMA Oncol. 2015;1(4):448-454. Erratum in: JAMA Oncol. 2015;1(8):1172.
- Nuciforo P, Radosevic-Robin N, Ng T, Scaltriti M. Quantification of HER family receptors in breast cancer. Breast Cancer Res. 2015;17:53.
- Nuciforo PG, Aura C, Holmes E, Prudkin L, Jimenez J, Martinez P, Ameels H, de la Peña L, Ellis C, Eidtmann H, Piccart-Gebhart MJ, Scaltriti M, Baselga J. Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status. Ann Oncol. 2015;26(7):1494-1500.
All publications
- Chic, Nuria ; Luen, Stephen J ; NUCIFORO, PAOLO GIOVANNI; Salgado, Roberto ; Fumagalli, Debora ; Hilbers, Florentine ; Wang, Yingbo ; de Azambuja, Evandro ; Làng, István ; DI COSIMO, SERENA; SAURA MANICH, CRISTINA; Huober, Jens ; PRAT APARICIO, ALEIX; Loi, Sherene. Tumor Cellularity and Infiltrating Lymphocytes (CelTIL) as a Survival Surrogate in HER2-Positive Breast Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE.1093/jnci/djab057
- Frigola, Joan; NAVARRO MENDIVIL, ALEJANDRO; Carbonell, Caterina ; Callejo, Ana ; Iranzo, Patricia ; CEDRES PEREZ, SUSANA; MARTINEZ MARTI, ALEXANDRE; PARDO ARANDA, NURIA; Saoudi-Gonzalez, Nadia ; Martinez, Debora ; JIMENEZ, JOSE; Sansano, Irene ; MANCUSO, FRANCESCO MATTIA; NUCIFORO, PAOLO GIOVANNI; Montuenga, Luis M ; Sánchez-Cespedes, Montse ; PRAT APARICIO, ALEIX; VIVANCOS PRELLEZO, ANA; FELIP FONT, ENRIQUETA; AMAT FERRER, RAMON. Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer. MOLECULAR ONCOLOGY. 2021 April. 10.1002/1878-0261.12891
- LIGERO HERNANDEZ, MARTA; Garcia-Ruiz, Alonso ; VIAPLANA DONATO, CRISTINA; VILLACAMPA JAVIERRE, GUILLERMO; Raciti, Maria V ; Landa, Jaid ; MATOS GARCIA, IGNACIO; MARTIN LIBERAL, JUAN JESUS; OCHOA DE OLZA AMAT, MARIA; HIERRO CARBO, CINTA; MATEO VALDERRAMA, JOAQUIN; Gonzalez, Macarena ; MORALES BARRERA, RAFAEL; SUAREZ RODRIGUEZ, CRISTINA; RODON AHNERT, JORDI; ELEZ FERNANDEZ, MARIA ELENA; BRAÑA GARCIA, IRENE; MUÑOZ COUSELO, EVA; OAKNIN BENZAQUEN, ANA MAZALTOB; FASANI, ROBERTA; NUCIFORO, PAOLO GIOVANNI; Gil, Debora ; RUBIO, ISABEL TERESA; SEOANE SUAREZ, JOAN; FELIP FONT, ENRIQUETA; Escobar, Manuel ; TABERNERO CATURLA, JOSEP; CARLES GALCERAN, JOAN; DIENSTMANN, RODRIGO; GARRALDA CABANAS, ELENA; PEREZ LOPEZ, RAQUEL. A CT-based Radiomics Signature Is Associated with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors. Radiology. 2021 April. 10.1148/radiol.2021200928
- RUBIO PEREZ, CARLOTA; Planas-Rigol, Ester ; Trincado, Juan L ; BONFILL TEIXIDOR, ESTER; ARIAS PIÑEIRO, ALEXANDRA; Marchese, Domenica ; Moutinho, Catia ; SERNA ALONSO, GARAZI; Pedrosa, Leire ; IURLARO, RAFFAELLA; Martínez-Ricarte, Francisco ; ESCUDERO MONREAL, LAURA; Cordero, Esteban ; Cicuendez, Marta ; Ruiz, Sara ; Parra, Genís ; NUCIFORO, PAOLO GIOVANNI; Gonzalez, Josep ; Pineda, Estela ; Sahuquillo, Juan ; TABERNERO CATURLA, JOSEP; Heyn, Holger ; SEOANE SUAREZ, JOAN. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. NATURE COMMUNICATIONS. 2020 March. 10.1038/s41467-021-21789-x
- Oliva, Marc ; MULET MARGALEF, NURIA; OCHOA DE OLZA AMAT, MARIA; Napoli, Stefania ; Mas, Joan ; Laquente, Berta ; Alemany, Laia ; Duell, Eric J ; NUCIFORO, PAOLO GIOVANNI; Moreno, Victor. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Tumor-Associated Microbiome: Where Do We Stand?. 2021 February. 10.3390/ijms22031446
- Hudecek, J. ; Voorwerk, L. ; van Seijen, M. ; Nederlof, I. ; de Maaker, M. ; van den Berg, J. ; van de Vijver, K.K. ; Sikorska, K. ; Adams, S. ; Demaria, S. ; Viale, G. ; Nielsen, T.O. ; Badve, S.S. ; Michiels, S. ; Symmans, W.F. ; Sotiriou, C. ; Rimm, D.L. ; Hewitt, S.M. ; Denkert, C. ; Loibl, S. ; Loi, S. ; Bartlett, J.M.S. ; Pruneri, G. ; Dillon, D.A. ; Cheang, M.C.U. ; Tutt, A. ; Hall, J.A. ; Kos, Z. ; Salgado, R. ; Kok, M. ; Horlings, H.M. ; Hyytiäinen, A. ; Hida, A.I. ; Thompson, A. ; Lefevre, A. ; Lazar, A.J. ; Gown, A. ; Lo, A. ; Sapino, A. ; Madabhushi, A. ; Moreira, A. ; Richardson, A. ; Vingiani, A. ; Beck, A.H. ; Bellizzi, A.M. ; Guerrero, A. ; Grigoriadis, A. ; Ehinger, A. ; Garrido-Castro, A. ; Vincent-Salomon, A. ; Laenkholm, A.-V. ; Sharma, A. ; Cimino-Mathews, A. ; Srinivasan, A. ; Acs, B. ; Singh, B. ; Calhoun, B. ; Haibe-Kans, B. ; Solomon, B. ; Thapa, B. ; Nelson, B.H. ; Gallas, B.D. ; Castaneda, C. ; Ballesteros-Merino, C. ; Criscitiello, C. ; Boeckx, C. ; Colpaert, C. ; Quinn, C. ; Chennubhotla, C.S. ; Swanton, C. ; Solinas, C. ; Hiley, C. ; Drubay, D. ; Bethmann, D. ; Moore, D.A. ; Larsimont, D. ; Sabanathan, D. ; Peeters, D. ; Zardavas, D. ; Höflmayer, D. ; Johnson, D.B. ; Thompson, E.A. ; Brogi, E. ; Perez, E. ; ElGabry, E.A. ; Stovgaard, E.S. ; Blackley, E.F. ; Roblin, E. ; Reisenbichler, E. ; Bellolio, E. ; Balslev, E. ; Chmielik, E. ; Gaire, F. ; Andre, F. ; Lu, F.-I. ; Azmoudeh-Ardalan, F. ; Rojo, F. ; Gruosso, T. ; Ciompi, F. ; Peale, F. ; Hirsch, F.R. ; Klauschen, F. ; Penault-Llorca, F. ; Acosta Haab, G. ; Farshid, G. ; van den Eynden, G. ; Curigliano, G. ; Floris, G. ; Broeckx, G. ; Gonzalez-Ericsson ; Koeppen, H. ; Haynes, H.R. ; McArthur, H. ; Joensuu, H. ; Olofsson, H. ; Lien, H.-C. ; Chen, I.-C. ; Cree, I. ; Frahm, I. ; Brcic, I. ; Chan, J. ; Ziai, J. ; Brock, J. ; Wesseling, J. ; Giltnane, J. ; Kerner, J.K. ; Thagaard, J. ; Braybrooke, J.P. ; van der Laak, J.A.W.M. ; Lemonnier, J. ; Zha, J. ; Ribeiro, J. ; Lennerz, J.K. ; Carter, J.M. ; Saltz, J. ; Hartman, J. ; Hainfellner, J. ; Quesne, J.L. ; Juco, J.W. ; Reis-Filho, J. ; Sanchez, J. ; Sparano, J. ; Cucherousset, J. ; Araya, J.C. ; Adam, J. ; Balko, J.M. ; Saeger, K. ; Siziopikou, K. ; Willard-Gallo, K. ; Weber, K. ; Pogue-Geile, K.L. ; Steele, K.E. ; Emancipator, K. ; AbdulJabbar, K. ; El Bairi, K. ; Blenman, K.R.M. ; Allison, K.H. ; Korski, K. ; Pusztai, L. ; Comerma, L. ; Buisseret, L. ; Cooper, L.A.D. ; Shi, L. ; Kooreman, L.F.S. ; Molinero, L. ; Estrada, M.V. ; Lacroix-Triki, M. ; Al Bakir, M. ; Sebastian, M.M. ; van de Vijver, M. ; Balancin, M.L. ; Dieci, M.V. ; Mathieu, M.-C. ; Rebelatto, M.C. ; Piccart, M. ; Hanna, M.G. ; Goetz, M.P. ; Preusser, M. ; Khojasteh, M. ; Sanders, M.E. ; Regan, M.M. ; Barnes, M. ; Christie, M. ; Misialek, M. ; Ignatiadis, M. ; van Bockstal, M. ; Castillo, M. ; Amgad, M. ; Harbeck, N. ; Tung, N. ; Laudus, N. ; Sirtaine, N. ; Burchardi, N. ; Ternes, N. ; Radosevic-Robin, N. ; Gluz, O. ; Grimm, O. ; NUCIFORO, PAOLO GIOVANNI; Jank, P. ; Gonzalez-Ericsson, P. ; Kirtani, P. ; Jelinic, P. ; Watson, P.H. ; Savas, P. ; Francis, P.A. ; Russell, P.A. ; Singh, R. ; Kim, R.S. ; Pierce, R.H. ; Hills, R. ; Leon-Ferre, R. ; de Wind, R. ; Shui, R. ; De Clercq, S. ; Leung, S. ; Tabbarah, S. ; Souza, S.C. ; O’Toole, S. ; Swain, S. ; Dudgeon, S. ; Willis, S. ; Ely, S. ; Kim, S.-R. ; Bedri, S. ; Irshad, S. ; Liu, S.-W. ; Goel, S. ; Hendry, S. ; Bianchi, S. ; Bragança, S. ; Paik, S. ; Wienert, S. ; Fox, S.B. ; Luen, S.J. ; Naber, S. ; Schnitt, S.J. ; Sua, L.F. ; Lakhani, S.R. ; Fineberg, S. ; Soler, T. ; Gevaert, T. ; D’Alfonso, T. ; John, T. ; Sugie, T. ; Kurkure, U. ; Bossuyt, V. ; Manem, V. ; Cámara, V.P. ; Tong, W. ; Chen, W. ; Yang, W. ; Tran, W.T. ; Wang, Y. ; Yuan, Y. ; Allory, Y. ; Husain, Z. ; Bago-Horvath, Z. Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials. NPJ breast cancer. 2020 January. 10.1038/s41523-020-0155-1
- Chic, Nuria ; Luen, Stephen J ; NUCIFORO, PAOLO GIOVANNI; Salgado, Roberto ; Fumagalli, Debora ; Hilbers, Florentine ; Wang, Yingbo ; de Azambuja, Evandro ; Làng, István ; DI COSIMO, SERENA; SAURA MANICH, CRISTINA; Huober, Jens ; PRAT APARICIO, ALEIX; Loi, Sherene. HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2020 January. 10.1093/jnci/djz042
- CAPDEVILA CASTILLON, JAUME; MATOS GARCIA, IGNACIO; MANCUSO, FRANCESCO MATTIA; Iglesias, Carmela; NUCIFORO, PAOLO GIOVANNI; Zafon, Carles ; GARCIA PALMER, HECTOR; OGBAH, ZIGHEREDA; Muinos, Laura ; HERNANDO CUBERO, JORGE; Villacampa, Guillermo ; Peña, Carol E ; TABERNERO CATURLA, JOSEP; Brose, Marcia S ; Schlumberger, Martin ; VIVANCOS PRELLEZO, ANA. Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial. MOLECULAR CANCER THERAPEUTICS. 2020 January. 10.1158/1535-7163.MCT-19-0211
- Cebrià-Costa, J P ; PASCUAL REGUANT, LAURA; Gonzalez-Perez, A ; Serra-Bardenys, G ; QUEROL PAÑOL, JESSICA; Cosín, M ; Verde, G ; Cigliano, R A ; Sanseverino, W ; Segura-Bayona, S ; Iturbide, A ; Andreu, D ; NUCIFORO, PAOLO GIOVANNI; Bernado-Morales, C ; RODILLA BENITO, VERONICA; ARRIBAS LOPEZ, JOAQUIN VICENTE; Yelamos, J ; de Herreros, A Garcia ; Stracker, T H ; PEIRO SALES, SANDRA. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. 2020 January. 10.1038/s41388-019-0969-1
- NUCIFORO, PAOLO GIOVANNI; Townend, J. ; SAURA MANICH, CRISTINA; de Azumbaja, E. ; Hilbers, F. ; Manukyants, A. ; Werutsky, G. ; Bliss, J. ; Moebus, V. ; Colleoni, M. ; Aspitia, A.M. ; Di Cosimo, S. ; Van dooren, V. ; Kroep, J. ; Ferro, A. ; Cameron, D. ; Gelber, R. ; Piccart-Gebhart, M. ; Huober, J. Nine-year survival outcome of neoadjuvant lapatinib with trastuzumab for HER2-positive breast cancer (NeoALTTO, BIG 1-06): final analysis of a multicentre, open-label, phase 3 randomised clinical trial. EUROPEAN JOURNAL OF CANCER. 2020 January. 10.1016/S0959-8049(20)30560-8
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