Published yesterday in Nature Cell Biology, research led by Roger Gomis, Head of the Growth Control and Cancer Metastasis Laboratory, Institute for Research in Biomedicine (IRB, Barcelona), in collaboration with several other leading centers across Spain including VHIO, has identified the genetic drivers promoting the latent asymptomatic state of breast cancer metastasis.
By advancing insights into the molecular basis underlying how the expression of certain genes contribute to metastatic spread, findings from this study represent an important next step in unlocking the many yet unresolved mysteries of metastastic cell spread.
First authored by Sylvia Gawrzak, formerly a PhD student at IRB Barcelona and currently a postdoc at the European Molecular Biology Laboratory (EMBL, Heidelberg, Germany), the researchers studied the most common type of breast cancer, estrogen-positive (ER+) that accounts for 70% of all breast cancer tumor cases. Characterised by a long period of latency with no symptom.
The team, including VHIO´s Violeta Serra, Principal Investigator of VHIO’s Experimental Therapeutics Group and Joaquín Arribas, Director of Preclinical Research at our Institute, ICREA Professor and Scientific Director of the virtual Center for the Biomedical Research Network in Oncology (CIBERONC), identified the protein kinase MSK1 as a key regulator of dormant or latent metastases.
Also in collaboration with Cristina Saura, Principal Investigator of VHIO’s Breast Cancer and Melanoma, Javier Cortés, Head of the Breast Cancer and Gynecological Tumors Department at Ramon y Cajal University Hospital in Madrid and Associate Translational Investigator at VHIO, results from this translational study performed in patient derived xenograft models (PDX), confirm that ER+ breast cancers that do not express MSK1 are associated with a higher risk of relapse earlier on.
Commenting for VHIO Communications, co-author Violeta Serra observes, “If precision medicine is to realize its true potential, we must collectively continue to raise the bar in more precisely predicting cancer’s next move as a strategy for reverting resistance to therapy and slamming the brakes on metastatic spread. Concerning the latter, this study may not only better identify those patients at most risk of disease relapse, but also lead to novel therapeutic avenues to mirror MSK1 kinase function towards prolonging the dormancy of metastatic breast cancer cells”.
To discover more about this study, also led in partnership with expert teams from the Hospital Clinic de Barcelona and Hospital del Mar, Barcelona, by co-authors Aleix Prat and Joan Albanell respectively, please see below.
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Source: Institute for Research in Biomedicine (IRB)
Researchers identify a protein that keeps metastatic breast cancer cells dormant
- A team of scientists headed by Roger Gomis at IRB Barcelona reveals one of the mechanisms that allows metastatic cells to leave a latent state.
The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body). A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light on the molecular basis underlying how the expression of certain genes facilitates the spread of metastatic lesions.
The team has studied the most common kind of breast tumour—estrogen-positive (ER +) and accounting for 80% of breast cancer tumour cases—that is characterised by a long period of latency with no symptoms. The study has been published today in Nature Cell Biology.
MSK1, the protein that keeps tumour cells dormant
The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases. Using clinical samples from patients, the scientists have confirmed that ER + breast cancer tumours that do not express MSK1 are associated with a risk of earlier relapse, while those that express this molecule will form metastases later.
“We are interested in understanding the mechanisms underlying metastasis and the time component of this process. Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,” explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.
The researchers believe that in the future this discovery may benefit patients in two ways. Firstly, it will help to identify those with an imminent risk of relapse and to adjust the treatment for this prognosis. Secondly, attempts could be made to design a treatment to mimic the function of MSK1 kinase, with the aim to maintain metastatic lesions in a latent and asymptomatic state for as long as possible.
The study published today was done in collaboration with the labs headed by Salvador Aznar Benitah and Angel R. Nebreda, both members of IRB Barcelona’s Oncology Programme, and with the labs led by Violeta Serra, at the Vall d’Hebrón Institute of Oncology (VHIO), Aleix Prat, at the Hospital Clínic de Barcelona, and Joan Albanell, at the Hospital del Mar. The first author of the article is Sylvia Gawrzak, a former “la Caixa” PhD student at IRB Barcelona who is currently doing a postdoc in EMBL, Heidelberg, Germany.
The study was funded by the Minstry of Economy and Competitiveness through ERDFs, the Generalitat de Catalunya through AGAUR, Worldwide Cancer Research and the Centro de Investigación Biomédica en Red de Oncología (CIBERONC) (Biomedical Research Networking Centre in Oncology), in which the researcher Roger Gomis participates.
Article of reference:
Sylwia Gawrzak, Lorenzo Rinaldi, Enrique J. Arenas, Fernando Salvador, Sara Gregorio, Federico Rojo, Ivan del Barco Barrantes, Juan Miguel Cejalvo, Marta Palafox, Marc Guiu, Antonio Berenguer-Llergo, Aikaterini Symeonidi, Jelena Urosevic, Anna Bellmunt, Daniela Kalafatovic, Anna Arnal-Estapé, Esther Fernández, Barbara Müllauer, Rianne Groeneveld, Konstantin Slobodnyuk, Camille Stephan-Otto Attolini,Cristina Saura, Joaquín Arribas, Javier Cortes, Ana Rovira, Montse Muñoz, Ana Lluch, Violeta Serra, Joan Albanell, Aleix Prat, Angel R. Nebreda, Salvador Aznar-Benitah & Roger R. Gomis
MSK1 regulates luminal cell differentiation and metastatic dormancy in breast cancer
Nature Cell Biology (2017) doi: 10.1038/s41556-017-0021-z
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