
Carolin Sauer
carolinsauer@vhio.net
Current position
- Group Leader of VHIO’s Cancer Genome Dynamics Group
Academic Qualifications
- 2022-2026: Postdoctoral Researcher and Marie Skłodowska Curie Actions (MSCA) fellow at the EMBL European Bioinformatics Institute, Cambridge, UK (PI: Isidro Cortés Ciriano)
- 2023-2025: Bye-Fellow and College Teaching Associate at Downing College, University of Cambridge, UK
- 2022-2025: Postdoctoral Affiliate at Newnham College, University of Cambridge, UK
- 2021-2025: Lead Trainer at the Centre for Research Informatics Training, University of Cambridge, UK
- 2017-2022: PhD in Medical Sciences at the University of Cambridge, Cancer Research UK Cambridge Institute (PI: James Brenton)
- 2015-2017: Research Assistant at the University of Manchester, UK (PI: David Ray)
- 2013-2017: BSc (Hons) in Biology at the University of Manchester, UK
Areas of Research
- Liquid biopsies for the analysis of cancer genome dynamics and evolution
- Early detection of cancers/relapse and monitoring of disease progression and treatment response
- Development of computational tools for the analysis cancer genomics
- Chromosomal instability and copy number aberrations
Prizes, Fellowships and Awards
- 2026-2029: La Caixa Junior Leader Fellowship
- 2023-2025: Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship
- 2022: Honourable Mention Award (PhD Thesis prize) from the Doctoral Research Award
- 2022: Nomination for the Milo Keynes Prize from the Department of Clinical Medicine (Cambridge) for outstanding thesis and viva performance
- 2017: Graduation price for best student in the BSc Hons Biology programme at the University of Manchester
- 2016: Society for Endocrinology Research Studentship funding
Most relevant scientific publications
Highlighted publications
(for full list of publications see Google Scholar or ORCID profiles)
Sauer CM, Tovey N, Ptasinska A, Hughes D, Stockton J, Zumalave S, Rust AG, Lynn C, Livellara V, Sevrin F, Lopez-Cortes A, Himsworth C, Muyas F, Nicolaidou M, Parry G, Paisana E, Cascão R, Waqar Ahmed S, Yasin SA, Rey Portela L, Balasubramanian P, Burke GAA, Vedi A, Faria CC, Marshall LV, Jacques TS, Hubank M, Hargrave D, George S, Angelini P, Anderson J, Chesler L, Beggs AD, Cortés-Ciriano I. Single-molecule cfDNA sequencing establishes clinical utility for ecDNA monitoring and multimodal liquid biopsy analysis. medRxiv. 2026. doi: 10.64898/2026.04.08.26350410
Elrick H*, Sauer CM*, Espejo Valle-Inclan J, Trevers K, Tanguy M, Zumalave S, De Noon S, Muyas F, Cascao R, Afonso A, Amary F, Tirabosco R, Giess A, Freeman T, Sosinsky A, Piculell K, Miller DT, Faria CC, Elgar G, Flanagan AM, Cortes-Ciriano I. SAVANA: reliable analysis of somatic structural variants and copy number aberrations in clinical samples using long-read sequencing. Nature Methods. 2025. 22, 1436-1446. doi: 10.1038/s41592-025-02708-0
Espejo Valle-Inclan J, De Noon S, Trevers K, Elrick H, van Belzen IAEM, Zumalave S, Sauer CM, Tanguy M, Butters T, Muyas F, Rust AG, Amary F, Tirabosco R, Giess A, Sosinsky A, Elgar G, Flanagan AM, Cortés-Ciriano I. Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution. Cell. 2025. 188, 352-370.e22. doi: 10.1016/j.cell.2024.12.005
Muyas F, Sauer C, Valle-Inclan JE, Li R, Rahbari R, Mitchell T, Hormoz S, Cortés-Ciriano I. De novo detection of somatic mutations in high-throughput single-cell profiling data sets. Nature Biotech. 2024. 42, 758–767. doi: 10.1038/s41587-023-01863-z
Sauer CM, Hall JA, Couturier D-L, Bradley T, Piskorz AM, Griffiths J, Sawle A, Eldridge M, Smith PS, Hosking K, Reinius MAV, Morrill Gavarró L, Mes-Masson A-M, Ennis D, Millan D, Hoyle A, McNeish IA, Jimenez-Linan M, Correia Martins F, Tischer J, Vias M, Brenton JD. Molecular landscape and functional characterization of centrosome amplification in ovarian cancer. Nature Communications. 2023. 14, 6505. doi: 10.1038/s41467-023-41840-3
Sauer CM*, Heider K*, Belic J, Boyle S, Hall J, Couturier D-L, An A, Vijayaraghavan A, Reinius MAV, Hosking K, Vias M, Rosenfeld N, and Brenton JD. Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models. EMBO Molecular Medicine. 2022. 14(8):e15729. doi: 10.15252/emmm.202215729