Biosketch Sandra Peiró

Biosketch Sandra Peiró
Sandra Peiró
speiro@vhio.net
LinkedIn
Current position
Academic Qualifications
  • PhD in Biochemistry, Barcelona University, Spain
  • BSc in Biochemistry, Barcelona University, Spain
Areas of Research

Biology and Biochemistry, chromatin structure, transcription regulation, epigenetics.

Prizes and Scholarships
  • 2015-Guest Professor, First CRG Course: The 3D structure of the genome: technical and computational approaches from 3C to Hi-C, CRG, Barcelona.
  • 2014-Awarded a Miguel Servet Contract II from the Spanish Ministry of Health.
  • 2013-Accreditation of Research, Agencia Catalana de Acreditació I Certificació.
  • 2013-Awarded Betty Hay Award TEMTIA for contributions to the field as a young female scientist who has established her laboratory within the last 5 years.
  • 2012-Assistant Professor, Faculty of Human Biology, Universitat Pompeu Fabra, Barcelona.
  • 2011–2015-Guest Professor, Genes & Function Course, Universitat Pompeu Fabra, Barcelona.
  • 2010-Assistant Professor, Faculty of Human Biology, Universitat Pompeu Fabra, Barcelona.
  • 2009-Awarded a Miguel Servet Contract from the Spanish Ministry of Health; selected from more than 250 applications.
  • 2007-Assistant Professor credentials, Agencia Catalana de Acreditació I Certificació.
  • 2005-Eukaryotic Gene Expression Course. One of 15 selected students from 50 international applicants. Cold Spring Harbor Laboratory, USA.
  • 2004-Awarded a Juan de la Cierva contract from the Spanish Ministry of Science and Innovation; selected from more than 250 applications
  • 2004-Awarded an AECC Investigator contract.
  • 1998–2001 Assistant Professor, Faculty of Medicine, Barcelona University, Barcelona.
  • 1996-First Award, Catalan Biology Society, Barcelona.
Projects
  1. Identificación y caracterización de nuevos elementos reguladores durante la adquisición de competencias metastásicas en un modelo de transición epitelio-mesénquima y en tumores de mama triple-negativos.
    Spanish Carlos III Health Institute (FIS)
    2019–2022
  2. Epigenetic Landscape Characterization of Cholangiocarcinomas.
    Fundació Marató TV3
    2020–2023
Most relevant scientific publications
  • Alcalà-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus- Muncunill , Ito Y, Blanco E, Golbano A, Crespí-Vázquez, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Masashi N, Pérez-Navarro E. Neuron type-specific increase in Lamin B1 contributes to nuclear dysfunction in Hubtington’s disease. EMBO Mol Med. 2021 Feb 5;13(2):e12105. Epub 2020 Dec 28.
  • Guerrero-Martinez J, Ceballos-Chávez M, Koehler F, Peiró S, Reyes JC. TGFβ Promotes Widespread Enhancer Chromatin Opening and Operates on Genomic Regulatory Domains. Nat Commun. 2020 Dec 3;11(1):6196.
  • Cebrià-Costa JP, Pascual-Reguant L, Gonzalez-Perez A, Serra-Bardenys G, Querol J, Cosín M, Verde G, Cigliano RA, Sanseverino W, Segura-Bayona S, Iturbide A, Andreu D, Nuciforo P, Bernado-Morales C, Rodilla V, Arribas J, Yelamos J, de Herreros AG, Stracker TH, Peiró S. LOXL2-mediated H3K4 oxidation reduced chromatin accessibility in triple negative breast cancer cells. Oncogene. 2020 Jan;39(1):79-121. Epub 2019 Aug 28.
  • Herranz N, Dave N, Millanes-Romero A, Pascual L, Morey L, Díaz VM, Lorenz-Fonfria V, Gutierrez-Gallego R, Jerónimo C, Itubide A, Di Croce L, García de Herreros A and Peiró S. Lysyl Oxidase-Like 2 (LOXL2) Oxidizes Trimethylated Lysine 4 in Histone H3. FEBS J. 2016
  • Itubide A, Pascual L, Fargas L, Cebrià JP, Alsina B, García de Herreros A and Peiró S. LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation. Mol Cell. 2015
  • Millanes-Romero A, Herranz  N,  Loubat  J,  Iturbide  A,  Perrera  V,  Gil  J,  Jenuwein  T,  García  de Herreros A and Peiró S. Regulation of Heterochromatin Transcription by Snail1/ LOXL2 During Epithelial to Mesenchymal Transition. Mol Cell. 2013.
  • Herranz N, Pasini D, Díaz V, Francí C, Gutierrez  A, Dave N, Escrivà M, Hernandez-Muñoz  I, di Croce  L,  Helin  K,  García  de  Herreros  A  and  Peiró  S.  Polycomb complex 2 is required for E- Cadherin repression by Snail1 transcription factor. Mol Cell Biol. 28: 47772-81. 2008.
  • Escrivà M*, Peiró S* (co-authors),  Herranz N, Villagrasa P, Dave N, Montserrat-Sentís  B, Murray SA, Francí C, Gridley T, Virtanen I and García de Herreros A. Repression of PTEN phosphatase by Snail1  transcriptional  factor  during  gamma  radiation-induced  apoptosis. Mol Cell Biol. 28: 1528-40. 2008.
All publications
  • Herranz N, Dave N, Millanes-Romero A, Pascual L, Morey L, Díaz VM, Lorenz-Fonfria V, Gutierrez-Gallego R, Jerónimo C, Itubide A, Di Croce L, García de Herreros A and Peiró S. Lysyl Oxidase-Like 2 (LOXL2) Oxidizes Trimethylated Lysine 4 in Histone H3. FEBS J. 2016
  • Frigola J, Iturbide A, Lopez-Bigas N, Peiró S and Gonzalez-Pérez A. Altered oncomodules underline chromatin regulatory factors driver mutations. Oncotarget.  2016.
  • Beltran M, Aparicio-Prat E, Mazzolini R, Millanes-Romero A, Massó P, Jenner R, Díaz V, Peiró S and Garcia de Herreros A. Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucl Acids Res. 2015
  • Itubide A, Pascual L, Fargas L, Cebrià JP, Alsina B, García de Herreros A and Peiró S. LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation. Mol Cell. 2015
  • Itubide A, García de Herreros A and Peiró S. A new role for LOX and LOXL2 proteins in transcription regulation. FEBS Lett. Upcoming Special Issue: Epigenetics. 2014
  • Cebrià JP, Millanes-Romero A, García de Herreros A and Peiró S. The Essential Role of Heterochromatin Transcription in Cellular Transitions: The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case. Mol Cell Oncol. 2014.
  • Millanes-Romero A, Herranz  N,  Loubat  J,  Iturbide  A,  Perrera  V,  Gil  J,  Jenuwein  T, García  de Herreros A and Peiró S. Regulation of Heterochromatin Transcription by Snail1/ LOXL2 During Epithelial to Mesenchymal Transition. Mol Cell. 2013.
  • Villagrasa P, Díaz VM, Viñas-Castells R, Peiró S, Del Valle-Pérez B, Dave N, Rodríguez-Asiain  A, Casal JI, Lizcano JM, Duñach M, García de Herreros A. Akt2 interacts with Snail1 in the E-Cadherin promoter. Oncogene. 2011.
  • Dave N, Guaita-Esteruelas  S, Gutarra S, Frias À, Beltran M, Peiró S, de Herreros AG. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem. 2011.
  • Garcia  de  Herreros  A,  Peiró  S,  Nassour  M,  Savagner  P.  Snail  family  regulation  and  epithelial mesenchymal transitions in breast cancer progression. J. Mammary Gland Biol Neoplasia. 2010.
  • Herranz N, Pasini D, Díaz V, Francí C, Gutierrez  A, Dave N, Escrivà M, Hernandez-Muñoz  I, di Croce  L,  Helin  K,  García  de  Herreros  A  and  Peiró  S.  Polycomb  complex  2  is  required  for  E- Cadherin repression by Snail1 transcription  factor. Mol Cell Biol. 28: 47772-81. 2008.
  • Escrivà M*, Peiró S* (co-authors),  Herranz N, Villagrasa P, Dave N, Montserrat-Sentís  B, Murray SA, Francí C, Gridley T, Virtanen I and García de Herreros A. Repression of PTEN phosphatase by Snail1  transcriptional  factor  during  gamma  radiation-induced  apoptosis. Mol Cell Biol. 28: 1528-40. 2008.
  • Mejias-Luque  R,  Peiró  S,  Vincent  A,  Van  Seuningen  I  and  de  Bolós  C.  IL-6  induces  MUC4 expression  through  go130/STAT3   pathway  in  gastric  cancer  cell  lines.  BBA  Mol Cell Res. 10: 1728-36. 2008.
  • Solanes G, Porta de la Riva M, Agustí C, Casagolda  D, Sanchez-Aguilera  F, Larriba MJ, Pons F, Peiró S, Escrivà M, Muñoz A, Duñach M, García de Herreros A and Baulida J. E-Cadherin controls b-catenin  and  NFkB  transcriptional  activity  in  mesenchymal  gene  expression. J Cell Sci. 121: 2224-34. 2008.
  • Wanami  L, Chen  H, Peiró  S, García  de Herreros  A and Bacheler R. Vascular  endothelial  growth factor-A stimulates Snail expression in breast tumor cells: Implications for tumor progression. Exp Cell Res. 13: 2448-53. 2008.
  • Ortiz-Zapater  E*, Peiró S* (co-authors),  Roda O, Coromines  JM, Aguilar S, Ampurdanes C, Real FX  and  Navarro  P. Tissue  plasminogen  activator  induces  pancreatic  cell proliferation  by  a non- catalytic mechanism that requires ERK1/2 activation through Epidermal Growth Factor receptor and Annexin A2. Am J Pathol. 170: 1573-84. 2007.
  • Peiró S, Escrivà M, Puig I, Barberà MJ, Dave N, Herranz N, Larriba MJ, Takkunen M, Francí C, Muñoz A, Virtanen I, Baulida J and García de Herreros A. Snail1 transcriptional  repressor binds to its own promoter and controls its expression. Nucl Acids Res. 34: 2077-84. 2006.
  • Palmer HG, Larriba MJ, Garicia JM, Ordoñez-Moran  P, Pena C, Peiró S, Puig I, Rodriguez De la Fuente  R, Bernad  A, Pollan  M, Bonilla  F, Gamallo  C, García  de Herreros  A and Muñoz  A. The transcription  factor  Snail1  represses  vitamin  D receptor expression  and responsiveness  in human colon cancer. Nat Med. 10: 917-19. 2004.
  • Barberà MJ, Dominguez D, Puig I, Julien-Grille S, Guaita S, Baulida J, Francí C, Peiró S, Deehar S, Laure L and García de Herreros A. Regulation of Snail transcription during epitelial to mesenchymal transition of tumor cells. Oncogene. 23: 7345-54. 2004.
  • Iularu M, Demontis F, Corada M, Zanetta L, Drake C, Gariboldi M, Peiró S, Cano A, Navarro P, Cattelino A, Tognin S, Marchisio PC and Dejana E. VE-Cadherin expression and clustering maintain low levels of surviving in endothelial cells. Am J Pathol. 165: 181-9. 2004.
  • Llovera M, de Pablo Y, Egea J, Encinas M, Peiró S, Martín-Zanca D, Rocamora N and Comella JX. Trk is a calmodulin-binding protein: Implications for receptor processing.  J Neurochem. 88: 422. 2004
Privacy Preferences
When you visit our website, it may store information through your browser from specific services, usually in form of cookies. Here you can change your privacy preferences. Please note that blocking some types of cookies may impact your experience on our website and the services we offer.
Privacy Policy
You have read and agreed to our privacy policy
Required