Genitourinary, Central Nervous System (CNS) Tumors, Sarcoma and Cancer of Unknown Primary Site Group

• Design and develop clinical trials covering all malignancies studied by our group. We seek to provide our patients with the most novel and optimal treatments including immune-based therapeutics, targeted  therapies and new chemotherapies.
• Conduct clinical trials at different stages of disease with emphasis on a histology-tailored design and multidisciplinary approach.
• Consolidate our biopsy program (mainly in bone), for patients with mCRPC to target genomic alterations including PI3K pathways, DNA repair genes, and androgen receptor alterations.
• Further consolidate our Kidney Cancer Task Force at VHIO in collaboration with researchers at the Vall d’Hebron Research Institute (VHIR) and Biomedical Research Institute of Bellvitge (IDIBELL).
• Microbiota studies as a biomarker for immunotherapies to treat bladder and kidney cancers.
• Expand our translational research platform for glioblastoma in collaboration with VHIO’s Gene Expression & Cancer Group.
• Develop our translational platform for GIST and expand research in collaboration with the Spanish Sarcoma Group (GEIS), and other European referral centers. We are also an active member of the European References Network (ERN).
• Develop new tools and techniques including liquid biopsy for our patients to more precisely tailor treatments against mCRPC, GIST and kidney cancer.

Most relevant scientific publications

• Sternberg CN, Castellano D, de Bono J, Fizazi K, Tombal B, Wülfing C, Kramer G, Eymard JC, Bamias A, Carles J, Iacovelli R, Melichar B, Sverrisdóttir Á, Theodore C, Feyerabend S, Helissey C, Poole EM, Ozatilgan A, Geffriaud-Ricouard C, de Wit R. Efficacy and Safety of Cabazitaxel Versus Abiraterone or Enzalutamide in Older Patients with Metastatic Castration-resistant Prostate Cancer in the CARD Study. Eur Urol. 2021 Oct;80(4):497-506.
• Neeb A, Herranz N, Arce-Gallego S, Miranda S, Buroni L, Yuan W, Athie A, Casals T, Carmichael J, Rodrigues DN, Gurel B, Rescigno P, Rekowski J, Welti J, Riisnaes R, Gil V, Ning J, Wagner V, Casanova-Salas I, Cordoba S, Castro N, Fenor de la Maza MD, Seed G, Chandran K, Ferreira A, Figueiredo I, Bertan C, Bianchini D, Aversa C, Paschalis A, Gonzalez M, Morales-Barrera R, Suarez C, Carles J, Swain A, Sharp A, Gil J, Serra V, Lord C, Carreira S, Mateo J, de Bono JS. Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. Eur Urol. 2021 Feb;79(2):200-211.
• Powles T, Carroll D, Chowdhury S, Gravis G, Joly F, Carles J, Fléchon A, Maroto P, Petrylak D, Rolland F, Cook N, Balar AV, Sridhar SS, Galsky MD, Grivas P, Ravaud A, Jones R, Cosaert J, Hodgson D, Kozarewa I, Mather R, McEwen R, Mercier F, Landers D. An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nat Med. 2021 May;27(5):793-801.
• Suárez C, Díaz-Mejía N, Morales-Barrera R, González M, Mateo J, Carles J. Metastatic nonclear renal cell carcinoma current review in evolving treatment strategies. Curr Opin Urol. 2021 May 1;31(3):242-248.
• Mateo J, Porta N, Bianchini D, McGovern U, Elliott T, Jones R, Syndikus I, Ralph C, Jain S, Varughese M, Parikh O, Crabb S, Robinson A, McLaren D, Birtle A, Tanguay J, Miranda S, Figueiredo I, Seed G, Bertan C, Flohr P, Ebbs B, Rescigno P, Fowler G, Ferreira A, Riisnaes R, Pereira R, Curcean A, Chandler R, Clarke M, Gurel B, Crespo M, Nava Rodrigues D, Sandhu S, Espinasse A, Chatfield P, Tunariu N, Yuan W, Hall E, Carreira S, de Bono JS. Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2020 Jan;21(1):162-174. Clinical Trial.
• Matos I, Martin-Liberal J, Garcia-Ruiz A, Hierro C, Ochoa de Olza M, Viaplana C, Azaro A, Vieito M, Braña I, Mur G, Ros J, Mateos J, Villacampa G, Berche R, Oliveira M, Alsina M, Elez E, Oaknin Ana, Munoz-Couselo E, Carles J, Felip E, Rodon J, Tabernero J, Dienstmann R, Perez-Lopez R, Garralda E. Capturing Hyperprogressive Disease with Immune-Checkpoint Inhibitors Using RECIST 1.1 Criteria. Clin Cancer Res. 2020 Apr 15;26(8):1846-1855.
• Morales-Barrera R, Suárez C, González M, Valverde C, Serra E, Mateo J, Raventos C, 03 Maldonado X, Morote J, Carles J. The future of bladder cancer therapy: Optimizing the inhibition of the fibroblast growth factor receptor. Cancer Treat Rev. 2020 Jun; 86. Article 102000.
• Fizazi K, Kramer G, Eymard JC, Sternberg CN, de Bono J, Castellano D, Tombal B, Whuelfing C, Liontos M, Carles J, Iacovelli R, Melichar B, Sverrisdottir A, Theodore C, Eyerabend S, Helissey C, Oudard S, Facchini G, Poole EM, Ozatilgan A, Geffriaud-Ricouard C, Bensfia S, de Wit R. Quality of life in patients with metastatic prostate cancer following treatment with cabazitaxel versus abiraterone or enzalutamide (CARD): an analysis of a randomised, multicentre, open-label, phase 4 study. Lancet Oncol. 2020 Nov;21(11):1513-1525.
• De Wit R, De Bono J, Sternberg CN, Fizazi K, Tombal B, Wulfing C, Kramer G, Eymard JC, Bamias A, Carles J, Iacovelli R, Melichar B, Sverrisdottir A, Theodore C, Feyerabend S, Helissey C, Ozatilgan A, Geffriaud-Ricouard C, Castellano D, CARD Investigators. Cabazitaxel versus abiraterone or enzalutamide in metastatic prostate cancer. N Engl J Med. 2019 Dec 26;381(26):2506-2518.
• Slovin S, Clark W, Carles J, Krivoshik A, Park JW, Wang F, George D. Seizure Rates in Enzalutamide-Treated Men With Metastatic Castration-Resistant Prostate Cancer and Risk of Seizure: The UPWARD Study. JAMA Oncol. 2018 May 4(5): 702-706.
• Carles J, Castellano D, Mendez-Vidal MJ, Mellado B, Saez MI, Gonzalez del Alba A, Perez-Gracia JL, Jimenez J, Suarez C, Sepulveda JM, Manneh R, Porras I, Lopez C, Morales-Barrera R, Arranz JA. Circulating tumor cells as a biomarker of survival and response to Radium-223 therapy: Experience in a cohort of patients with metastatic castration-resistant prostate cancer. Clin Genitourin Cancer. 2018 Dec;16(6):e1133-e1139.
• Miller K, Carles J, Gschwend JE, Van Poppel H, Diels J, Brookman-May SD. The Phase 3 COU-AA-302 Study of Abiraterone Acetate Plus Prednisone in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Stratified Analysis Based on Pain, Prostate-specific Antigen, and Gleason Score. Eur Urol. 2018 Jul 74 (1): 17-23.
• Carles J, Pichler A, Korunkova H, Tomova A, Ghosn M, El Karak F, Makdessi J, Koroleva I, Barnes G, Bury D, Ozatilgan A, Hitier S, Katolicka J. An observational, multicentre study of cabazitaxel in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (CAPRISTANA). BJU Int. 2019 Mar;123(3):456-464. Epub 2018 Sep 16.
• Eisenberger M, Hardy-Bessard AC, Kim CS, Géczi L, Ford D, Mourey L, Carles J, Parente P, Font A, Kacso G, Chadjaa M, Zhang W, Bernard J, de Bono J. Phase III Study Comparing a Reduced Dose of Cabazitaxel (20 mg/m2) and the Currently Approved Dose (25 mg/m2) in Postdocetaxel Patients With Metastatic Castration-Resistant Prostate Cancer-PROSELICA. J Clin Oncol. 2017 Oct 1;35(28):3198-3206.
• García-Donas J, Font A, Pérez-Valderrama B, Virizuela JA, Climent MÁ, Hernando-Polo S, Arranz JÁ, Del Mar Llorente M, Lainez N, Villa-Guzmán JC, Mellado B, Del Alba AG, Castellano D, Gallardo E, Anido U, Del Muro XG, Domènech M, Puente J, Morales-Barrera R, Pérez-Gracia JL, Bellmunt J. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial. Lancet Oncol. 2017 May;18(5):672-681.
• Necchi A, Sonpavde G, Lo Vullo S, Giardiello D, Bamias A, Crabb SJ, Harshman LC, Bellmunt J, De Giorgi U, Sternberg CN, Cerbone L, Ladoire S, Wong YN, Yu EY, Chowdhury S, Niegisch G, Srinivas S, Vaishampayan UN, Pal SK, Agarwal N, Alva A, Baniel J, Golshayan AR, Morales-Barrera R, Bowles DW, Milowsky MI, Theodore C, Berthold DR, Daugaard G, Sridhar SS, Powles T, Rosenberg JE, Galsky MD, Mariani L; RISC Investigators. Nomogram-based Prediction of Overall Survival in Patients with Metastatic Urothelial Carcinoma Receiving First-line Platinum-based Chemotherapy: Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC). Eur Urol. 2017 Feb;71(2):281-289.
• Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A. A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors. Cancer Discov.2017 Jan;7(1):102-113.
• Saad F, Carles J, Gillessen S, Heidenreich A, Heinrich D, Gratt J, Lévy J, Miller K, Nilsson S, Petrenciuc O, Tucci M, Wirth M, Federhofer J, O’Sullivan JM; Radium-223 International Early Access Program Investigators. Radium-223 and concomitant therapies in patients with metastatic castration-resistant prostate cancer: an international, early access, open-label, single-arm phase 3b trial. Lancet Oncol. 2016 Sep;17(9):1306-16.
• Moran S, Martínez-Cardús A, Sayols S, Musulén E, Balañá C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Miró M, Matias-Guiu X, Pazo-Cid R, Antón A, Lopez-Lopez R, Soler G, Longo F, Guerra I, Fernandez S, Assenov Y, Plass C, Morales R, Carles J, Bowtell D, Mileshkin L, Sia D, Tothill R, Tabernero J, Llovet JM, Esteller M. Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. Lancet Oncol. 2016 Oct;17(10):1386-1395.
• Jiménez-Valerio G, Martínez-Lozano M, Bassani N, Vidal A, Ochoa-de-Olza M, Suárez C, García-Del-Muro X, Carles J, Viñals F, Graupera M, Indraccolo S, Casanovas O. Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients. Cell Rep. 2016 May 10;15(6):1134-43.
• Morales-Barrera R, Suárez C, de Castro AM, Racca F, Valverde C, Maldonado X, Bastaros JM, Morote J, Carles J. Targeting fibroblast growth factor receptors and immune checkpoint inhibitors for the treatment of advanced bladder cancer: New direction and New Hope. Cancer Treat Rev. 2016 Nov; 50: 208-216.
• Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Srinivas S, Morales-Barrera R, Carles J, Al-Wardat R, Al-Rabi K, Maakoseh M.  Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model. Clin Genitourin Cancer 2016 Jun; 14(3): 255-60
• Serrano C, Romagosa C, Hernandez-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Verges R, Domínguez R, Carles J, Ramón y Cajal S.  RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Cancer 2016 Jan; 122(1): 99-107
• Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE.  Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015 Feb; 16(2): 152-60
• De Mattos-Arruda L, Mayor R, Ng CK, Weigelt B, Martínez-Ricarte F, Torrejón D, Oliveira M, Arias A, Raventós C, Tang J, Guerini-Rocco E, Martínez-Sáez E, Lois S, Marín O, de la Cruz X, Piscuoglio S, Towers R, Vivancos A, Peg V, Ramón y Cajal S, Carles J, Rodón J, González-Cao M, Tabernero J, Felip E, Sahuquillo J, Berger MF, Cortes J, Reis-Filho JS, Seoane J.  Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat Commun 2015; 6: 8839
• Smith MR, Rathkopf DE, Mulders PF, Carles J, Van Poppel H, Li J, Kheoh T, Griffin TW, Molina A, Ryan CJ.  Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. J. Urol. 2015 Nov; 194(5): 1277-84
• Suárez C, Morales-Barrera R, Ramos V, Nuñez I, Valverde C, Planas J, Morote J, Maldonado X, Carles J.  Role of immunotherapy in castration-resistant prostate cancer (CRPC). BJU Int. 2014 Mar; 113(3): 367-75
• Morales-Barrera R, Suárez C, Valverde C, Nuñez I, Maldonado X, Morote J, Carles J.  Do patients with metastatic urothelial carcinoma benefit from docetaxel as second-line chemotherapy? Clin Transl Oncol 2014 Jan; 16(1): 102-6
• Simonetti S, Serrano C, Hernandez-Losa J, Bagué S, Orellana R, Valverde C, Lleonart ME, Aizpurua M, Carles J, Ramón y Cajal S, Romagosa C.  Schwannomas, benign tumors with a senescent phenotype.Histol. Histopathol. 2014 Jun; 29(6): 721-30
• Prior C, Pérez-Gracia JL, García-Donas J, Rodriguez-Antona C, Guruceaga E, Esteban E, Suárez C, Castellano D, del Alba AG, Lozano MD, Carles J, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Gurpide A, Lopez-Picazo JM, Hernandez AG, Mellado B, Martínez E, Moreno F, Font A, Calvo A.  Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS ONE 2014; 9(1): e86263

All publications

• Characterizing CDK12-Mutated Prostate Cancers. Rescigno P, Gurel B, Pereira R, Crespo M, Rekowski J, Rediti M, Barrero M, Mateo J, Bianchini D, Messina C, de la Maza MD, Fenor C, Khobe CJ, Guo C, Paschalis A, Sharp A, Seed G, Figueiredo I, Lambros M, Miranda S, Ferreira A, Bertan C, Riisnaes R, Porta N, Yuan W, Carreira S, de Bono J. S Clin Can Res. 2021 Jan; 27 (2): 566-574.
• Genetic counseling in prostate cancer How to implement it in daily clinical practice?. Borque-Fernando A, Espilez R, Miramar D, Corbaton D, Rodriguez A, Castro E, Mateo J, Rello L, Mendez A, Gil Sanz M. J. Actas Urol Españolas. 2021 Jan; 45 (1): 8-20.
• miRNA landscape in primary tumors and matched metastases in gastrointestinal stromal tumors. Ravegnini G, Serrano C, Ricci R, Zhang Q, Terrenato I, Graziosi A, Valori G, Landolfi S, Hrelia P, Angelini S. Epigenomics. 2021 Jan; 13 (5): 369 – 377.
• Ripretinib in gastrointestinal stromal tumor: the long-awaited step forward. Lostes-Bardaji MJ, García-Illescas D, Valverde C, Serrano C. Ther Adv Med Oncol. 2021 Jan;  713:1758835920986498.
• A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study. Martínez-Trufero J, De Sande-González LM, Luna P, Martin-Broto J, Álvarez R, Marquina G, Diaz-Beveridge R, Poveda A, Cano JM, Cruz-Jurado J, López Pousa A, Vaz Salgado MA, Valverde-Morales CM, Sevilla I, Martínez-García J, Rubio-Casadevall J, De Juan A, Carrasco JA, Moura DS, Gurruchaga-Sotes I, Gutiérrez A. Cancers. 2021 Feb 14; 13(4):792.
• Advanced prostate cancer with ATM loss: PARP and ATR inhibitors. Neeb A, Herranz N, Arce-Gallego S, Miranda S, Buroni L, Yuan W, Athie  A, Casals T, Carmichael J, Nava Rodrigues D, Gurel B, Rescigno P, Rekowski J, Welti J, Riisnaes R, Gil V, Ning J, Wagner V, Casanova-Salas I, Cordoba S, Castro N, Fenor de la Maza MD, Seed G, Chandran K, Ferreira A, Figueiredo I, Bertan C, Bianchini D, Aversa C, Paschalis A, Gonzalez M, Morales-Barrera R, Suarez C, Carles J, Swain A, Sharp A, Gil J, Serra V, Lord C, Carreira S, Mateo J, de Bono J. Eur Urol. 2021 Feb; 79 (2): 200 – 211.
• Avapritinib in Patients With Advanced Gastrointestinal Stromal Tumors Following at Least 3 Prior Lines of Therapy.Avapritinib in Patients With Advanced Gastrointestinal Stromal Tumors Following at Least 3 Prior Lines of Therapy. George S, Jones RL, Bauer S, Kang YK, Schöffski P, Eskens F, Mir O, Cassier PA, Serrano C, Tap WD, Trent J, Rutkowski P, Patel S, Chawla SP, Meiri E, Gordon M, Zhou T, Roche M, Heinrich MC, von Mehren M. Oncologist. 2021 Feb; 26 (4): E639 – E649.
• Liquid Biopsy in Gastrointestinal Stromal Tumors: Ready for Prime Time? Gómez-Peregrina D, García-Valverde A, Pilco-Janeta D, Serrano C. Treat Options Oncol. 2021 Feb; 22 (4): 32.
• The very favorable metastatic renal cell carcinoma (mRCC) risk group: Data from the International Metastatic RCC Database Consortium (IMDC). Schmidt AL, Wanling X, Gan CL, Wells C, Dudani S, Donskov F, Porta C, Suárez C, Szabados B, Wood L, Ruiz Morales JM, Tran B, Bjarnason GA, Yuasa T, Beuselinck B, Hansen AR, Agarwal N, Bakouny Z, Chin Heng DY, Choueiri TK. J Clin Oncol. 2021 Feb, 39 (6). Meeting abstract.
• Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial. Jones RL, Serrano C, von Mehren M, George S, Heinrich MC, Kang YK, Schöffski P, Cassier PA, Mir O, Chawla SP, Eskens FALM, Rutkowski P, Tap WD, Zhou T, Roche M, Bauer S. Eur J Cancer. 2021 Mar; 145: 132 – 142.
• Emerging drugs for the treatment of gastrointestinal stromal tumors. Pilco-Janeta D, García-Valverde A, Gómez-Peregrina D, Serrano C. Expert Opin Emerg Drugs. 2021 Mar; 26 (1): 53 – 62.
• Minimizing acquisition -related radiomics variability by image resampling and batch effect correction to allow for large-scale data analysis Eur. M Ligero, O Jordi-Ollero, K Bernatowicz, A Garcia-Ruiz, E Delgado-Muñoz, D Leiva, R Mast, C Suárez, R Sala-Llonch, N Calvo, M Escobar, A Navarro-Martin, G Villacampa, R Dienstmann, R Perez-Lopez. Eur Radiol. 2021 Mar; 31 (3):  1460 – 1470.
• Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma. Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, Suárez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Żołnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ. N Engl J Med. 2021 Mar; 384 (9): 829 – 841.
• A CT-based Radiomics Signature Is Associated with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors. Ligero M, Garcia Ruiz A, Viaplana C, Villacampa G, Raciti V, Landa J, Matos I, Liberal JM, Ochoa de-Olza M, Hierro C, Mateo J, Gonzalez M, Morales-Barrera R, Suárez C, Rodon J, Elez E, Braña I, Munoz-Couselo E, Oaknin A, Fasani R, Nuciforo P, Gil D, Rubio Perez C, Seoane J, Felip E, Escobar M, Tabernero J, Carles J, Dienstmann R, Garralda E, Perez-Lopez R. Radiology. 2021 Apr; 299 (1): 109 – 119.
• Association between BRCA2 alterations and intraductal and cribriform histologies in prostate cancer. Lozano R, Salles DC, Sandhu S, Aragon IM, Thorne H, Lopez-Campos F, Rubio-Briones J, Gutierrez-Pecharroman AM, Maldonado L, di Domenico T, Sanz A, Prieto JD, Garcia I, Pacheco M, Garces T, Llacer C, Romero-Laorden N, Zambrana F, Lopez-Casas PP, Lorente D, Mateo J Pritchard CC, Antonarakis ES, Olmos D, Lotan TL, Castro E. Eur J Can. 2021 Apr;147:74-83.
• Atezolizumab in locally advanced or metastatic urothelial cancer: a pooled analysis from the Spanish patients of the IMvigor 210 cohort 2 and 211 studies. Sotelo M, Alonso-Gordoa T, Gajate P, Gallardo E, Morales-Barrera R, Pérez-Gracia JL, Puente J, Sánchez P, Castellano D, Durán I. Clin Transl Oncol. 2021 Apr; 23(4):882-891.
• Genomic Testing in Patients with Metastatic Castration-resistant Prostate Cancer: A Pragmatic Guide for Clinicians. Merseburger AS, Waldron N, Ribal MJ, Heidenreich A, Perner S, Fizazi K, Sternberg CN, Mateo J, Wirth MP, Castro E, Olmos D, Petrylak DP, Chowdhury S. Eur Urol. 2021 Apr; 79 (4): 519 – 529.
• Powles T, Carroll D, Chowdhury S, Gravis G, Joly F, Carles J, Fléchon A, Maroto P, Petrylak D, Rolland F, Cook N, Balar AV, Sridhar SS, Galsky MD, Grivas P, Ravaud A, Jones R, Cosaert J, Hodgson D, Kozarewa I, Mather R, McEwen R, Mercier F, Landers D. An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nat Med. 2021 May;27(5):793-801.
• Efficacy and Safety of Atezolizumab Plus Bevacizumab Following Disease Progression on Atezolizumab or Sunitinib Monotherapy in Patients with Metastatic Renal Cell Carcinoma in IMmotion150: A Randomized Phase 2 Clinical. Powles T, Atkins MB, Escudier B, Motzer RJ, Rini BI, Fong L, Joseph RW, Pal SK, Sznol M, Hainsworth J, Stadler WM, Hutson TE, Ravaud A, Bracarda S, Suárez C, Choueiri TK, Reeves J, Cohn A, Ding B, Leng N, Hashimoto K, Huseni M, Schiff C, Mc Dermott DF. Eur Urol. 2021 May; 79 (5): 665 – 673.
• Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS). Grivas P, Loriot Y, Morales-Barrera R, Teo MY, Zakharia Y, Feyerabend S, Vogelzang NJ, Grande E, Adra N, Alva A, Necchi A, Rodriguez-Vida A, Gupta S, Josephs DH, Srinivas S, Wride K, Thomas D, Simmons A, Loehr A, Dusek RL, Nepert D, Chowdhury S. BMC Cancer. 2021 May; 24 21(1):593.
• Metastatic non clear renal cell carcinoma current review in evolving treatment strategies.  Suárez C, Díaz-Mejía N, Morales-Barrera R, González M, Mateo J, Carles J. Curr Opin Urol. 2021 May 1; 31(3): 242-248.
• SEOM clinical guideline for management of adult medulloblastoma (2020). Luque R, Benavides M, Del Barco S, Egaña L, García-Gómez J, Martínez-García M, Pérez-Segura P, Pineda E, Sepúlveda JM, Vieito M. Clin Transl Oncol. 2021 May;23(5):940-947.
• SEOM Clinical Guideline of management of soft-tissue sarcoma (2020). De Juan Ferré A, Álvarez Álvarez R, Casado Herráez A, Cruz Jurado J, Estival González A, Martín-Broto J, Martínez Marín V, Moreno Vega A, Sebio García A, Valverde Morales C. Clin Transl Oncol. 2021 May; 23(5):922-930.
• Value of Early Circulating Tumor Cells Dynamics to Estimate Docetaxel Benefit in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients. Lozano R, Lorente D, Aragon IM, Romero-Laorden N, Nombela P, Mateo J, Reid AHM, Cendon Y, Bianchini D, Llacer C, Sandhu SK, Sharp A, Rescigno P, Garces T, Pacheco MI, Flohr P, Massard C, Lopez-Casas PP, Castro Elena, de Bono JS, Olmos David. Cancers. 2021 May. 13 (10): 2334.
• A New Prognostic Model in Patients with Advanced Urothelial Carcinoma Treated with First-line Immune Checkpoint Inhibitors. Khaki AR, Li A, Diamantopoulos LN, Miller NJ, Carril-Ajuria L, Castellano D, De Kouchkovsky I, Koshkin V, Park J, Alva A, Bilen MA, Stewart T, Santos V, Agarwal N, Jain J, Zakharia Y, Morales-Barrera R, Devitt M, Nelson A, Hoimes CJ, Shreck E, Gartrell BA, Sankin A, Tripathi A, Zakopoulou R, Bamias A, Rodriguez-Vida A, Drakaki A, Liu S, Kumar V, Lythgoe MP, Pinato DJ, Murgic J, Fröbe A, Joshi M, Isaacsson Velho P, Hahn N, Alonso Buznego L, Duran I, Moses M, Barata P, Galsky MD, Sonpavde G, Yu EY, Shankaran V, Lyman GH, Grivas P. Eur Urol Oncol. 2021 Jun; 4 (3):464-472.
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• Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS). Garcia del Muro X, de Alava E, Artigas V, Bague S, Braña A, Cubedo R, Cruz J, Mulet-Margalef N, Narvaez JA, Martinez Tirado O, Valverde C, Verges R, Viñals J, Martin-Broto J; Spanish Group for Research on Sarcoma.  Cancer Chemother Pharmacol. 2016 Jan;77(1):133-46.
• RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Serrano C, Romagosa C, Hernández-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Vergés R, Domínguez R, Carles J, Ramón Y Cajal S. Cancer. 2016 Jan 1;122(1):99-107.
• A Phase 2 Open Label, Single-Arm Trial to Evaluate the Combination of Cetuximab Plus Taxotere, Cisplatin, and 5-Flurouracil as an Induction Regimen in Patients With Unresectable Squamous Cell Carcinoma of the Head and Neck. Mesía R, Vázquez S, Grau JJ, García-Sáenz JA, Lozano A, García C, Carles J, Irigoyen A, Mañós M, García-Paredes B, del Barco E, Taberna M, Escobar Y, Cruz JJ; Spanish Head and Neck Cancer Cooperative Group (TTCC).  Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):289-96.
• Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study. Lainez N, García-Donas J, Esteban E, Puente J, Sáez MI, Gallardo E, Pinto-Marín Á, Vázquez-Estévez S, León L, García-Carbonero I, Suárez-Rodríguez C, Molins C, Climent-Duran MA, Lázaro-Quintela M, González Del Alba A, Méndez-Vidal MJ, Chirivella I, Afonso FJ, López-Brea M, Sala-González N, Domenech M, Basterretxea L, Santander-Lobera C, Gil-Arnáiz I, Fernández O, Caballero-Díaz C, Mellado B, Marrupe D, García-Sánchez J, Sánchez-Escribano R, Fernández Parra E, Villa Guzmán JC, Martínez-Ortega E, Belén González M, Morán M, Suarez-Paniagua B, Lecumberri MJ, Castellano D.  BMC Cancer. 2016 Feb 22;16:135.
• Expert Recommendations for First-Line Management of Metastatic Renal Cell Carcinoma in Special Subpopulations. Puente J, García Del Muro X, Pinto Á, Láinez N, Esteban E, Arranz JÁ, Gallardo E, Méndez MJ, Maroto P, Grande E, Suárez C.  Target Oncol. 2016 Apr;11(2):129-4.
• Validation of the International Metastatic Renal-Cell Carcinoma Database Consortium (IMDC) prognostic model for first-line pazopanib in metastatic renal carcinoma: the Spanish Oncologic Genitourinary Group (SOGUG) SPAZO study. Pérez-Valderrama B, Arranz Arija JA, Rodríguez Sánchez A, Pinto Marín A, Borrega García P, Castellano Gaunas DE, Rubio Romero G, Maximiano Alonso C, Villa Guzmán JC, Puertas Álvarez JL, Chirivella González I, Méndez Vidal MJ, Juan Fita MJ, León-Mateos L, Lázaro Quintela M, García Domínguez R, Jurado García JM, Vélez de Mendizábal E, Lambea Sorrosal JJ, García Carbonero I, González del Alba A, Suárez Rodríguez C, Jiménez Gallego P, Meana García JA, García Marrero RD, Gajate Borau P, Santander Lobera C, Molins Palau C, López Brea M, Fernández Parra EM, Reig Torras O, Basterretxea Badiola L, Vázquez Estévez S, González Larriba JL. Ann Oncol. 2016 Apr;27(4):706-11.
• Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer. Agarwal N, Machiels JP, Suárez C, Lewis N, Higgins M, Wisinski K, Awada A, Maur M, Stein M, Hwang A, Mosher R, Wasserman E, Wu G, Zhang H, Zieba R, Elmeliegy M. Oncologist. 2016 May;21(5):535-6.
• Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients. Jiménez-Valerio G, Martínez-Lozano M, Bassani N, Vidal A, Ochoa-de-Olza M, Suárez C, García-Del-Muro X, Carles J, Viñals F, Graupera M, Indraccolo S, Casanovas O.  Cell Rep. 2016 May 10;15(6):1134-43.
• Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model. Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Srinivas S, Morales-Barrera R, Carles J, Al-Wardat R, Al-Rabi K, Maakoseh M. Clin Genitourin Cancer. 2016 Jun;14(3):255-60.
• Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models. López de Maturana E, Picornell A, Masson-Lecomte A, Kogevinas M, Márquez M, Carrato A, Tardón A, Lloreta J, García-Closas M, Silverman D, Rothman N, Chanock S, Real FX, Goddard ME, Malats N; SBC/EPICURO Study Investigators.  BMC Cancer. 2016 Jun 3;16:351.
• Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study. Maurel J, López-Pousa A, Calabuig S, Bagué S, Del Muro XG, Sanjuan X, Rubió-Casadevall J, Cuatrecasas M, Martinez-Trufero J, Horndler C, Fra J, Valverde C, Redondo A, Poveda A, Sevilla I, Lainez N, Rubini M, García-Albéniz X, Martín-Broto J, de Alava E.  Clin Sarcoma Res. 2016 Jun 29;6:10.
• Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment. Masson-Lecomte A, López de Maturana E, Goddard ME, Picornell A, Rava M, González-Neira A, Márquez M, Carrato A, Tardon A, Lloreta J, Garcia-Closas M, Silverman D, Rothman N, Kogevinas M, Allory Y, Chanock SJ, Real FX, Malats N; SBC/EPICURO Study Investigators.  Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1144-50.
• A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma. Brandes AA, Carpentier AF, Kesari S, Sepulveda-Sanchez JM, Wheeler HR, Chinot O, Cher L, Steinbach JP, Capper D, Specenier P, Rodon J, Cleverly A, Smith C, Gueorguieva I, Miles C, Guba SC, Desaiah D, Lahn MM, Wick W. Neuro Oncol. 2016 Aug;18(8):1146-56.
• Radium-223 and concomitant therapies in patients with metastatic castration-resistant prostate cancer: an international, early access, open-label, single-arm phase 3b trial. Saad F, Carles J, Gillessen S, Heidenreich A, Heinrich D, Gratt J, Lévy J, Miller K, Nilsson S, Petrenciuc O, Tucci M, Wirth M, Federhofer J, O’Sullivan JM; Radium-223 International Early Access Program Investigators. Lancet Oncol. 2016 Sep;17(9):1306-16.
• Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. Moran S, Martínez-Cardús A, Sayols S, Musulén E, Balañá C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Miró M, Matias-Guiu X, Pazo-Cid R, Antón A, Lopez-Lopez R, Soler G, Longo F, Guerra I, Fernandez S, Assenov Y, Plass C, Morales R, Carles J, Bowtell D, Mileshkin L, Sia D, Tothill R, Tabernero J, Llovet JM, Esteller M. Lancet Oncol. 2016 Oct;17(10):1386-1395.
• Targeting fibroblast growth factor receptors and immune checkpoint inhibitors for the treatment of advanced bladder cancer: New direction and New Hope. Morales-Barrera R, Suárez C, de Castro AM, Racca F, Valverde C, Maldonado X, Bastaros JM, Morote J, Carles J. Cancer Treat Rev. 2016 Nov; 50: 208-216.
• Hormonal changes after localized prostate cancer treatment. Comparison between external beam radiation therapy and radical prostatectomy. Planas J, Celma A, Placer J, Maldonado X, Trilla E, Salvador C, Lorente D, Regis L, Cuadras M, Carles J, Morote J. Actas Urol Esp. 2016 Nov;40(9):549-555.
• SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016). Poveda A, Martinez V, Serrano C, Sevilla I, Lecumberri MJ, de Beveridge RD, Estival A, Vicente D, Rubió J, Martin-Broto J.Clin Transl Oncol. 2016 Dec;18(12):1221-1228.
• SEOM Clinical Guideline of management of soft-tissue sarcoma (2016). López-Pousa A, Martin Broto J, Martinez Trufero J, Sevilla I, Valverde C, Alvarez R, Carrasco Alvarez JA, Cruz Jurado J, Hindi N, Garcia Del Muro X.  Clin Transl Oncol. 2016 Dec;18(12):1213-1220.
• Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Srinivas S, Morales-Barrera R, Carles J, Al-Wardat R, Al-Rabi K, Maakoseh M.  Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model. Clin Genitourin Cancer 2016 Jun; 14(3): 255-60
• Serrano C, Romagosa C, Hernandez-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Verges R, Domínguez R, Carles J, Ramón y Cajal S.  RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Cancer 2016 Jan; 122(1): 99-107
• Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE.  Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015 Feb; 16(2): 152-60
• De Mattos-Arruda L, Mayor R, Ng CK, Weigelt B, Martínez-Ricarte F, Torrejón D, Oliveira M, Arias A, Raventós C, Tang J, Guerini-Rocco E, Martínez-Sáez E, Lois S, Marín O, de la Cruz X, Piscuoglio S, Towers R, Vivancos A, Peg V, Ramón y Cajal S, Carles J, Rodón J, González-Cao M, Tabernero J, Felip E, Sahuquillo J, Berger MF, Cortes J, Reis-Filho JS, Seoane J.  Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat Commun 2015; 6: 8839
• Smith MR, Rathkopf DE, Mulders PF, Carles J, Van Poppel H, Li J, Kheoh T, Griffin TW, Molina A, Ryan CJ.  Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. J. Urol. 2015 Nov; 194(5): 1277-84
• Suárez C, Morales-Barrera R, Ramos V, Nuñez I, Valverde C, Planas J, Morote J, Maldonado X, Carles J.  Role of immunotherapy in castration-resistant prostate cancer (CRPC). BJU Int. 2014 Mar; 113(3): 367-75
• Morales-Barrera R, Suárez C, Valverde C, Nuñez I, Maldonado X, Morote J, Carles J.  Do patients with metastatic urothelial carcinoma benefit from docetaxel as second-line chemotherapy? Clin Transl Oncol 2014 Jan; 16(1): 102-6
• Simonetti S, Serrano C, Hernandez-Losa J, Bagué S, Orellana R, Valverde C, Lleonart ME, Aizpurua M, Carles J, Ramón y Cajal S, Romagosa C.  Schwannomas, benign tumors with a senescent phenotype.Histol. Histopathol. 2014 Jun; 29(6): 721-30
• Prior C, Pérez-Gracia JL, García-Donas J, Rodriguez-Antona C, Guruceaga E, Esteban E, Suárez C, Castellano D, del Alba AG, Lozano MD, Carles J, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Gurpide A, Lopez-Picazo JM, Hernandez AG, Mellado B, Martínez E, Moreno F, Font A, Calvo A.  Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS ONE 2014; 9(1): e86263
• Castellano DE, Bellmunt J, Maroto JP, Font-Pous A, Morales-Barrera R, Ghanem I, Suárez C, Martín Lorente C, Etxaniz O, Capdevila L, Coronado C, Alfaro V, Siguero M, Fernández-Teruel C, Carles J. Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen. Cancer Chemother. Pharmacol. 2014 Apr; 73(4): 857-67
• Rathkopf DE, Smith MR, de Bono JS, Logothetis CJ, Shore ND, de Souza P, Fizazi K, Mulders PF, Mainwaring P, Hainsworth JD, Beer TM, North S, Fradet Y, Van Poppel H, Carles J, Flaig TW, Efstathiou E, Yu EY, Higano CS, Taplin ME, Griffin TW, Todd MB, Yu MK, Park YC, Kheoh T, Small EJ, Scher HI, Molina A, Ryan CJ, Saad F.  Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302). Eur. Urol. 2014 Nov; 66(5): 815-25
• Foro P, Algara M, Lozano J, Rodriguez N, Sanz X, Torres E, Carles J, Reig A, Membrive I, Quera J, Fernandez-Velilla E, Pera O, Lacruz M, Bellosillo B.  Relationship between radiation-induced apoptosis of T lymphocytes and chronic toxicity in patients with prostate cancer treated by radiation therapy: a prospective study. Int. J. Radiat. Oncol. Biol. Phys. 2014 Apr; 88(5): 1057-63
• Morote J, Planas J, Maldonado X, Carles J.  Non-metastatic castration-resistant prostate cancer (CPRCM0), an old scenario with renewed clinical interest. Actas Urol Esp 2014 Sep; 38(7): 419-20
• Bellmunt J, Suárez C, Gallardo E, Rodón J, Pons F, Bonfill T, Beltran M, Moya I, Galtes S, Albanell J, Carles J.  Phase I study of sunitinib in combination with gemcitabine and capecitabine for first-line treatment of metastatic or unresectable renal cell carcinoma. Oncologist 2014 Sep; 19(9): 917-8
• Morote J, Celma A, Planas J, Placer J, de Torres I, Olivan M, Carles J, Reventos J, Doll A.  Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness. Int J Mol Sci 2014; 15(8): 13615-23
• Serrano C, Simonetti S, Hernandez-Losa J, Valverde C, Carrato C, Bagué S, Orellana R, Somoza R, Moliné T, Carles J, Huguet P, Romagosa C, Ramón y Cajal S.  BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumours. Histopathology 2013 Feb; 62(3): 499-504
• Morote J, Ropero J, Planas J, Bastarós JM, Delgado G, Placer J, Celma A, de Torres IM, Carles J, Reventos J, Doll A.  Metabolic syndrome increases the risk of aggressive prostate cancer detection. BJU Int. 2013 Jun; 111(7): 1031-6
• Mesia R, Rueda A, Vera R, Lozano A, Medina JA, Aguiar D, Árias F, Triana G, Carles J, Lopez-Lopez R.  Adjuvant therapy with cetuximab for locally advanced squamous cell carcinoma of the oropharynx: results from a randomized, phase II prospective trial. Ann. Oncol. 2013 Feb; 24(2): 448-53
• Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE.  Abiraterone in metastatic prostate cancer without previous chemotherapy. N. Engl. J. Med. 2013 Jan; 368(2): 138-48
• de la Piedra C, Alcaraz A, Bellmunt J, Meseguer C, Gómez-Caamano A, Ribal MJ, Vazquez F, Anido U, Samper P, Esteban E, Álvarez-Ossorio JL, Lara PC, San José LA, Contreras JA, del Alba AG, González-Gragera B, Tabernero AJ, González-Enguita C, Fernández JM, García-Escudero A, Gómez-Veiga F, Méndez MJ, Segarra J, Virizuela JA, Carles J, Lassa A, Calderero V, Constela M, Delgado D, Mañas A, Murias A, Reynes G, Rodriguez B, Rubio G, Sánchez E, Unda M, Solsona E, Martínez-Javaloyas JM, Comet-Batlle J, Quicios C, Martín-Fernández M, Mahillo-Fernández I, Morote J. Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study. Br. J. Cancer 2013 Jun; 108(12): 2565-72
• Alcaraz A, González-López R, Morote J, de la Piedra C, Meseguer C, Esteban E, Climent M, González-Gragera B, Álvarez-Ossorio JL, Chirivella I, Mellado B, Lara PC, Vazquez F, Contreras JA, Carles J, Murias A, Calderero V, Comet-Batlle J, González-Del Alba A, León-Mateos L, Mañas A, Segarra J, Lassa A, González-Enguita C, Méndez MJ, Samper P, Unda M, Mahillo-Fernández I, Bellmunt J.  Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study.Br. J. Cancer 2013 Jul; 109(1): 121-30
• Serrano C, Morales R, Suárez C, Nuñez I, Valverde C, Rodón J, Humbert J, Padrós O, Carles J. Emerging therapies for urothelial cancer. Cancer Treat. Rev. 2012 Jun; 38(4): 311-7
• Castellano D, Carles J, Esteban E, Trigo JM, Climent MA, Maroto JP, del Muro XG, Font A, Paz-Ares L, Arranz JA, Bellmunt J.  Recommendations for the optimal management of early and advanced urothelial carcinoma. Cancer Treat. Rev. 2012 Aug; 38(5): 431-41
• Carles J, Castellano D, Climent MA, Maroto P, Medina R, Alcaraz A.  Castration-resistant metastatic prostate cancer: current status and treatment possibilities. Clin Transl Oncol 2012 Mar; 14(3): 169-76
• Carles J, Chirivella I, Climent MA, Gallardo E, Gonzalez Del Alba A, Maroto JP, Mellado B, García del Muro FX.  Evaluation of patients with metastatic renal cell carcinoma after failure of first-line treatment. Cancer Metastasis Rev. 2012 Sep; 31 Suppl 1: S3-9
• Morales-Barrera R, Bellmunt J, Suárez C, Valverde C, Guix M, Serrano C, Gallen M, Carles J.  Cisplatin and gemcitabine administered every two weeks in patients with locally advanced or metastatic urothelial carcinoma and impaired renal function. Eur. J. Cancer 2012 Aug; 48(12): 1816-21
• Cózar JM, Solsona E, Morote J, Miñana B, Maroto JP, Gonzalez Del Alba A, Climent MA, Carles J, Alcaraz A, Castellano D.  [Recomendations on the management of controversies in advanced castrate-resistant prostate cancer]. Actas Urol Esp 2012; 36(10): 569-77
• Alcaraz A, Medina R, Maroto P, Climent MA, Castellano D, Carles J.  [Castration-resistant prostate cancer: where are we going?]. Actas Urol Esp 2012 Jun; 36(6): 367-74
• Morales R, Font A, Carles J, Isla D.  SEOM clinical guidelines for the treatment of invasive bladder cancer. Clin Transl Oncol 2011 Aug; 13(8): 552-9
• Bellmunt J, González-Larriba JL, Prior C, Maroto P, Carles J, Castellano D, Mellado B, Gallardo E, Pérez-Gracia JL, Aguilar G, Villanueva X, Albanell J, Calvo A.  Phase II study of sunitinib as first-line treatment of urothelial cancer patients ineligible to receive cisplatin-based chemotherapy: baseline interleukin-8 and tumor contrast enhancement as potential predictive factors of activity. Ann. Oncol. 2011 Dec; 22(12): 2646-53
• Morales-Barrera R, Valverde C, Rodón J, Pérez J, Maldonado X, Suárez C, Trilla E, Carles J.  Bilateral testicular germ cell tumours: a single hospital experience. Clin Transl Oncol 2010 Apr; 12(4): 299-302
• Carles J, Nogué M, Sole JM, Foro P, Domènech M, Suarez M, Gallardo E, García D, Ferrer F, Gelabert-Mas A, Gayo J, Fabregat X.  Phase II study of vinorelbine and estramustine in combination with conformational radiotherapy for patients with high-risk prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 2010 Mar; 76(4): 1085-91
• Serrano C, Suárez C, Andreu J, Carles J.  Acute aortic dissection during sorafenib-containing therapy.Ann. Oncol. 2010 Jan; 21(1): 181-2
• Pérez-García J, Morales R, Valverde CM, Rodón J, Suárez C, Semidey ME, Garcia-Patos V, Bartralot R, Serra M, Carles J.  Eccrine porocarcinoma presenting with scrotal lymphedema: a case report and review of systemic treatment. Ann. Oncol. 2010 Apr; 21(4): 907
• Bellmunt J, Maroto-Rey P, Trigo JM, Carles J, Guillem V, López-Martín JA, Antón-Torres A, Urruticoechea L.  A phase II trial of first-line sorafenib in patients with metastatic renal cell carcinoma unwilling to receive or with early intolerance to immunotherapy: SOGUG Study 06-01. Clin Transl Oncol 2010 Jul; 12(7): 503-8
• Suárez C, Morales R, Muñoz E, Rodón J, Valverde CM, Carles J.  Molecular basis for the treatment of renal cell carcinoma. Clin Transl Oncol 2010 Jan; 12(1): 15-21
• Bellmunt J, Trigo JM, Calvo E, Carles J, Pérez-Gracia JL, Rubió J, Virizuela JA, López R, Lázaro M, Albanell J.  Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06). Lancet Oncol. 2010 Apr; 11(4): 350-7
• Carles J, Morales R, Perez JM, Suárez C, Rodón J, Valverde C.  Management and interpretation of novel toxicities of molecular targeted therapies: renal toxicities. Eur. J. Cancer 2009 Sep; 45 Suppl 1: 309-17
• Bellmunt J, Théodore C, Demkov T, Komyakov B, Sengelov L, Daugaard G, Caty A, Carles J, Jagiello-Gruszfeld A, Karyakin O, Delgado FM, Hurteloup P, Winquist E, Morsli N, Salhi Y, Culine S, von der Maase H.  Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J. Clin. Oncol. 2009 Sep; 27(27): 4454-61
• Bellmunt J, Macià F, Malmusi D, Llorente JA, Carles J, Lloreta J, Foro P, Gelabert A, Albanell J, Castells X.  Impact of PSA implementation and combined radiation and hormonal therapy (RT+HT) on outcome of prostate cancer patients. Eur. J. Cancer 2009 Nov; 45(16): 2804-9
• Bellmunt J, Carles J, Albanell J.  Predictive modelling in hormone-refractory prostate cancer (HRPC). Clin Transl Oncol 2009 Feb; 11(2): 82-5
• Martínez P, Valverde C, Morales R, Rodón J, Suárez C, Baselga J, Carles J.  Docetaxel activity in second line treatment for urothelial carcinoma: a retrospective analysis European Journal of Cancer Supplements 2009 September; 7(2): 448
• Carles J, Font A, Mellado B, Domènech M, Gallardo E, González-Larriba JL, Catalan G, Alfaro J, Gonzalez Del Alba A, Nogué M, Lianes P, Tello JM.  Weekly administration of docetaxel in combination with estramustine and celecoxib in patients with advanced hormone-refractory prostate cancer: final results from a phase II study. Br. J. Cancer 2007 Nov; 97(9): 1206-10
• Carles J, Esteban E, Climent M, Font A, González-Larriba JL, Berrocal A, Garcia-Ribas I, Marfa X, Fabregat X, Albanell J, Bellmunt J.  Gemcitabine and oxaliplatin combination: a multicenter phase II trial in unfit patients with locally advanced or metastatic urothelial cancer. Ann. Oncol. 2007 Aug; 18(8): 1359-62

1. GISTomics: estudio de los perfiles genómicos y transcriptómicos en pacientes con GIST multirresistente con finalidad terapéutica.
   PI: César Serrano.
   Entity: Instituto de Salud Carlos III (ISCIII).
   Duration: 01/01/2021 – 31/12/2024.
2. Molecular landscape of resistance to KIT/PDGFRA inhibition in gastrointestinal stromal tumors.
   PI: César Serrano.
   Entity: Asociación Española Contra el Cáncer (AECC).
3. Patrones evolutivos de resistencia a la inhibición de KIT en GIST.
   PI: César Serrano.
   Entity: Instituto de Salud Carlos III (ISCIII).
4. DIVAS- DIssecting VAsculas Sarcomas
   PIs: Claudia Valverde and César Serrano.
   Entity: Asociación Angio-Vyda.
5. Relevancia biológica y clínica de estudios transcriptómicos en GIST.
   PI, Co-PI: Daniel Pilco Janeta, César Serrano.
   Entity: SENESCYT.
6. P-FIS 2019: Biomarkers based on DNA repair defects for prostate cancer Stratification.
   PI, Co-PI: Sara Arce, Joaquin Mateo.
   Entity: Instituto de Salud Carlos III (ISCIII).
7. Leveraging the AR-DDR interaction in advanced prostate cancer towards precision design of combination therapies with PARP inhibitors.
   Entity:  Asociación Española Contra el Cáncer (AECC).
8. PERIS FELLOWSHIP 2019: Combined analysis of liquid biopsies to monitor tumor evolution and anticancer therapy response.
   PI, Co-PI: Irene Casanova-Salas, Joaquin Mateo.
   Entity: PERIS.
   Participation: Coordinator.
9. FIS: Prostate cancer molecular profiles associated with DNA repair defects towards the development of precision medicine strategies.
   Entity: Instituto de Salud Carlos III (ISCIII)/ FIS Program.
   PI: Joaquin Mateo.
10. Clinical Qualification of DNA Repair Defects as Biomarkers in Metastatic Prostate Cancer Using Integrated Genomics and Tissue-Based Functional Assays.
    PI, Co-PIs: Joaquin Mateo, Colin Pritchard, David Olmos.
    Entity: U.S. Department of Defense (DoD).
11. Novel approaches to liquid biopsy in prostate cancer to inform precision medicine. Vall d’ Hebron Institute of Oncology.
    Entity: Fundación FERO.
    PI: Joaquín Mateo.
    Duration: 02/09/2019 – 01/09/2021.
12. Co-targeting androgen receptor signalling and DNA damage repair for precisión therapy in advanced prostate cancer (AR-DDR).
    PI: Joaquín Mateo.
    Entity: European Commission H2020 Program.
13. Impact of Centralization of Pathological Diagnosis in Expert Centers in Sarcoma.
    Entity: Fundación Mari Paz Jiménez Casado.
    PI: Cleofé Romagosa (Claudia Valverde).
14. Testing the malignant peripheral nerve sheath tumor vulnerability to precision therapies directed to recurrent genomic alterations.
    Entity: Fundació la Marató TV3.
    PI: Eduard Serres (Claudia Valverde).