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Grupo de Oncology Data Science (ODysSey)

Oncology Data Science (ODysSey) Group

El Grupo ODysSey del VHIO promueve la investigación traslacional en oncología de precisión mediante la integración de datos de perfiles moleculares del cáncer con los resultados clínicos de los pacientes oncológicos tratados en el Hospital Universitario Vall d’Hebron (HUVH).

Para analizar macrodatos y datos reales, diseñamos y mantenemos bases de datos clinicomoleculares integrales y desarrollamos sistemas personalizados de apoyo a la toma de decisiones para los investigadores interesados en los análisis correlativos para la generación de hipótesis y la validación de biomarcadores. También prestamos ayuda a los investigadores en el cálculo del tamaño de la muestra, el diseño del ensayo clínico y los análisis estadísticos posteriores.

Nuestro equipo también participa en proyectos internacionales de análisis de datos multiómicos y fomenta la investigación colaborativa en oncología computacional. Nos dedicamos a poner en contacto a los investigadores del cáncer que trabajan en la elaboración de modelos de predicción y pronóstico, la identificación de los impulsores del cáncer, la determinación del subtipo molecular, la heterogeneidad de las metástasis primarias, las firmas de microambientes y la farmacibilidad en tumores sólidos.

En colaboración con Susana Aguilar, Jennifer González y el Grupo de Genómica del Cáncer, el Grupo de Oncología Molecular, el Grupo de Desarrollo Clínico Precoz de Fármacos del VHIO y la Unidad de Investigación en Terapia Molecular del Cáncer (UITM) – CaixaResearch, codirigimos el programa interno de Preselección del VHIO.

Rodrigo Dientsmann
Jefe de grupo

Facilitar los estudios correlativos clinicomoleculares en el VHIO:

  • Desarrollo y mantenimiento de bases de datos clinicomoleculares y programas informáticos de apoyo a la toma de decisiones como recursos para médicos, patólogos moleculares e investigadores traslacionales.
  • Ofrecer orientación a oncólogos médicos y biólogos del cáncer sobre el diseño y la interpretación de los estudios correlativos de biomarcadores, así como sobre el desarrollo y la validación de pruebas basadas en la ómica que tengan una aplicación clínica directa.

Promover la medicina basada en la evidencia y el reclutamiento para ensayos clínicos:

  • Formación médica continua con informes estandarizados de alteraciones genómicas y reuniones semanales del Consejo de Tumores Moleculares. Facilitamos el intercambio de datos entre un gran número de expertos para la revisión de los historiales médicos de los pacientes y los perfiles moleculares del cáncer con el fin de informar y orientar con mayor precisión las decisiones terapéuticas.
  • Desarrollo y mantenimiento de OncoTrialsTrack (https://oncotrialstrack.vhio.net), una herramienta que facilita a los profesionales sanitarios la difícil y larga tarea de encontrar el ensayo clínico más adecuado para los pacientes con cáncer y ponerse en contacto con los investigadores para discutir y remitir el caso.

Investigación colaborativa sobre macrodatos y datos reales:

  • Generación de bases de datos de alta calidad que permitan el estudio de asociaciones complejas entre la ómica tumoral, la sensibilidad a los fármacos y el resultado del paciente.
  • Fomentar las interacciones entre científicos de oncología computacional e investigadores preclínicos y clínicos para promover la identificación de subtipos de cáncer y factores de farmacibilidad.
Oncology Data Science (ODysSey) Group
Jefe de grupo
Rodrigo Dientsmann
Bioestadístico
Guillermo Villacampa
Ingeniera biomédica
Anna Pedrola
Conservadoras de datos
Raquel Comas
Magdalena Guardiola
Fiorella Ruiz
Cristina Viaplana
Carla Sanchez
Sara Torres

Publicaciones científicas más relevantes

  • Tamborero D, Dienstmann R, Rachid MH, Boekel J, Baird R, Braña I, De Petris L, Yachnin J,Massard C, Opdam FL, Schlenk R, Vernieri C, Garralda E, Masucci M, Villalobos X, Chavarria E; Cancer Core Europe consortium, Calvo F, Fröhling S, Eggermont A, Apolone G, Voest EE, Caldas C, Tabernero J, Ernberg I, Rodon J, Lehtiö J. Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal. Nat Med. 2020;26(7):992-994.
  • Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I,Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F. Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group. Ann Oncol. 2020;S0923- 7534(20):39971-3.
  • Wagner AH, Walsh B, Mayfield G, Tamborero D, Sonkin D, Krysiak K, Deu-Pons J, Duren RP, Gao J, McMurry J, Patterson S, Del Vecchio Fitz C, Pitel BA, Sezerman OU, Ellrott K, Warner JL, Rieke DT, Aittokallio T, Cerami E, Ritter DI, Schriml LM, Freimuth RR, Haendel M, Raca G, Madhavan S, Baudis M, Beckmann JS, Dienstmann R, Chakravarty D, Li XS, Mockus S, Elemento O, Schultz N, Lopez- Bigas N, Lawler M, Goecks J, Griffith M, Griffith OL, Margolin AA; Variant Interpretation for Cancer Consortium. A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer. Nat Genet. 2020;52(4):448-457.
  • Dienstmann R, Garralda E, Aguilar S, Sala G, Viaplana C, Ruiz-Pace F, González-Zorelle J, Grazia LoGiacco D, Ogbah Z, Ramos Masdeu L, Mancuso F, Fasani R, Jimenez J, Martinez P, Oaknin A, Saura C, Oliveira M, Balmaña J, Carles J, Macarulla T, Elez E, Alsina M, Braña I, Felip E, Tabernero J, Rodon J, Nuciforo P, Vivancos A. Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials. JCO Precis Oncol. 2020 May 14;4:PO.19.00398.
  • Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J. Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer. Ann Oncol. 2019 Oct 1;30(10):1622-1629.
  • Dienstmann R, Connor K, Byrne AT; COLOSSUS Consortium. Precision Therapy in RAS Mutant Colorectal Cancer. Gastroenterology 2020;158(4):806-811.
  • Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S, Tabernero J. Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 2017;7(2):79-92.
  • Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J. Prediction of overall survival in stage II and III colon cancer beyond the American Joint Commission on Cancer TNM system: a retrospective, pooled biomarker study. Ann Oncol. 2017;28(5):1023-1031.
  • Dienstmann R, Elez E, Argiles G, Matos I, Sanz-Garcia E, Ortiz C, Macarulla T, Capdevila J, Alsina M, Sauri T, Verdaguer H, Vilaro M, Ruiz-Pace F, Viaplana C, Garcia A, Landolfi S, Palmer HG, Nuciforo P, Rodon J, Vivancos A, Tabernero J. Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights. Mol Oncol. 2017;11(9):1263-1272.
  • Dienstmann R, Tabernero J. Cancer: A precision approach to tumor treatment. Nature. 2017 Aug 3;548(7665):40-41.
  • Dienstmann R, Jang IS, Bot B, Friend S, Guinney J. Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors. Cancer Discov 2015 Feb; 5(2): 118-23
  • Dienstmann R, Patnaik A, Garcia-Carbonero R, Cervantes A, Benavent M, Roselló S, Tops BB, van der Post RS, Argiles G, Skartved NJ, Hansen UH, Hald R, Pedersen MW, Kragh M, Horak ID, Braun S, Van Cutsem E, Tolcher AW, Tabernero J. Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer. Cancer Discov 2015 Jun; 5(6): 598-609
  • Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S. The consensus molecular subtypes of colorectal cancer. Nat. Med. 2015 Nov; 21(11): 1350-6

Todas las publicaciones

  • Evidence-based neoadjuvant endocrine therapy for breast cancer. Dienstmann R, Bines J. Clin Breast Cancer 2006;7(4):315-20.
  • Phase II trial of neoadjuvant chemotherapy using alternating doublets in non-small cell lung cancer. Martins RG, Dienstmann R, Biasi P, Dantas K, Santos VO, Toscano E, Roriz W, Zamboni M, Sousa A, Ferreira CG, Small I, Moreira D, Zukin M. Clin Lung Cancer 2007;8(4):257-63.
  • Phase II trial of neoadjuvant gemcitabine and cisplatin in patients with invasive bladder carcinoma. Herchenhorn D, Dienstmann R, Peixoto FA, Campos FS, Santos VO, Moreira DM, Cardoso H, Small I, Ferreira CG. Int Braz J Urol 2007;33(5):630-8.
  • Palliative percutaneous nephrostomy in recurrent cervical cancer: Retrospective analysis of 50 consecutive cases Dienstmann R, Pinto CS, Pereira MT, Small I, Ferreira CG. J Pain Symptom Manage 2008;36(2):185-90.
  • XAF1 mRNA expression improves progression-free and overall survival for patients with advanced bladder cancer treated with neoadjuvant chemotherapy Pinho MB, Costas F, Sellos J, Dienstmann R, Andrade PB, Herchenhorn D, Peixoto FA, Santos VO, Small IA, Guimarães DP, Ferreira CG. Urol Oncol 2009;27(4):382-90.
  • Necitumumab (IMC-11F8), a fully human IgG1 mAb directed against epidermal growth factor receptor for the intravenous treatment of cancer. Dienstmann R, Tabernero J. Curr Opin Investig Drugs 2010;11(12):1434-41.
  • Recent developments in anti-cancer Agents targeting PI3K, Akt and mTORC1/2. Dienstmann R, Rodon J, Tabernero J. Recent Pat Anticancer Drug Discov 2011;6(2):210-36.
  • Targeting the PI3K-Akt-mTOR pathway – beyond rapalogs. Markman B, Dienstmann R, Tabernero J. Oncotarget 2010;1(7):530-43.
  • BRAF as a target for cancer therapy. Dienstmann R, Tabernero J. Anticancer Agents Med Chem 2011;11(3):285-95.
  • Molecular predictors of response to chemotherapy in colorectal cancer. Dienstmann R, Vilar E, Tabernero J. Cancer J 2011;17(2):114-26.
  • Personalizing therapy with targeted agents in non-small cell lung cancer. Dienstmann R, Martinez P, Felip E. Oncotarget 2011;2(3):165-77.
  • Combined modality therapy of stage IIIC breast cancer. Dienstmann R, Branco LG, Rezende LM, Freitas LC, Lima CF, Rodrigues GJ, Noronha Filho H, Sarmento RMB, Small I, Bines J. Breast J 2011;17(3):331-3.
  • Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development. Dienstmann R, Felip E. Expert Opin Biol Ther 2011;11(9):1223-31.
  • The development of molecular biomarkers in the individualized treatment of colorectal cancer. De Mattos-Arruda L, Dienstmann D, Tabernero J. Clin Colorectal Cancer 2011;10(4):279-89.
  • Risk-benefit assessment of bevacizumab in the treatment of breast cancer. Dienstmann R, Ades F, Saini KS, Metzger-Filho O. Drug Saf 2012;35(1):15-25.
  • Toxicity as biomarker of efficacy of molecular targeted therapies: focus on EGFR and VEGFR inhibiting anticancer agents. Dienstmann R, Braña I, Rodon J, Tabernero J. Oncologist 2011;16(12):1729-40.
  • Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer. Dienstmann R, De Dosso S, Felip E, Tabernero J. Mol Oncol 2012;6(1):15-26.
  • Application of monoclonal antibodies as cancer therapy in solid tumors. Dienstmann R, Markman B, Tabernero J. Curr Clin Pharmacol 2012;7(2):137-45.
  • Panitumumab: summary of clinical development in colorectal cancer and future directions. Argiles G, Dienstmann R, Tabernero J. Future Oncol 2012;8(4):373-89.
  • Molecular prescreening to select patient population in early clinical trials. Rodón J, Saura C, Dienstmann R, Vivancos A, Cajal SR, Baselga J, Tabernero J. Nat Rev Clin Oncol 2012;9(6):359-66
  • Molecular profiling of patients with colorectal cancer and matched targeted therapy in Phase 1 clinical trials. Dienstmann R, Serpico D, Rodon J, Saura C, Macarulla T, Elez ME, Alsina M, Capdevila J, Perez-Garcia J, Sánchez-Ollé G, Aura C, Prudkin L, Landolfi S, Hernández-Losa J, Vivancos A, Tabernero J. Mol Cancer Ther 2012;11(9):2062-71.
  • Drug development in the era of personalized oncology: from population-based trials to enrichment and prescreening strategies. Dienstmann R, Rodon J, Tabernero J. Am Soc Clin Oncol Educ Book 2012;32:168-72.
  • Development of PI3K inhibitors: lessons learned from early clinical trials. Rodon J, Dienstmann R, Serra V, Tabernero J. Nat Rev Clin Oncol 2013;10(3):143-53.
  • Biomarker-driven patient selection for early clinical trials. Dienstmann R, Rodon J, Barretina J, Tabernero J. Curr Opin Oncol 2013;25(3):305-12.
  • The genomic medicine frontier in human solid tumors: prospects and challenges. Dienstmann R, Rodon J, Barretina J, Tabernero J. J Clin Oncol 2013;31(15):1874-84.
  • Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E, Cortes J, Iafrate AJ, Nuciforo P, Tabernero J. Annals Oncol 2014;25(3):552-63.
  • Activity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial. Bines  J, Dienstmann R, Obadia RM, Branco LGB, Quintella DC, Castro TM, Camacho PG, Soares F, Costa MEF. Annals Oncol 2014;25(4):831-6.
  • Tumor Growth Rate (TGR) analysis in Phase I clinical trials–Letter. Dienstmann R, Tabernero J. Clin Cancer Res 2014;20(9):2495-6.
  • Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors. Dienstmann R, Rodon J, Serra V, Tabernero J. Mol Cancer Ther 2014;13(5):1021-31.
  • Standardized decision support in sequencing reports of somatic cancer variants. Dienstmann R, Dong F, Borger D, Dias-Santagata D, Ellisen LW, Le LP, Iafrate AJ. Mol Oncol 2014;8(5):859-873.
  • The evolution of our molecular understanding of colorectal cancer: what we are doing now, what the future holds, and how tumor profiling is just the beginning. Dienstmann R, Salazar R, Tabernero J. Am Soc Clin Oncol Educ Book 2014;34:91-9.
  • Optimal design of trials to demonstrate the utility of genomically-guided therapy: putting Precision Cancer Medicine to the test. Dienstmann R, Rodon J, Tabernero J. Mol Oncol 2014;S1574-7891(14)00150-1.
  • Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors. Soria JC, DeBraud F, Bahleda R, Adamo B, Andre F, Dienstmann R, Delmonte A, Cereda R, Isaacson J, Litten J, Allen A, Dubois F, Saba C, Robert R, D’Incalci M, Zucchetti M, Camboni MG, Tabernero J. Ann Oncol 2014;25(11):2244-51.
  • Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes. Sinicrope FA, Shi Q, Smyrk TC, Thibodeau SN, Dienstmann R, Guinney J, Bot BM, Tejpar S, Delorenzi M, Goldberg RM, Mahoney M, Sargent DJ, Alberts SR. Gastroenterology 2015;148(1):88-99.
  • Social interactomes for enabling research communities. Guinney J, Dienstmann R, Ferté C, Friend S, McCormick F. Cancer Discov 2014;4(11):1265-8.
  • Stepwise group sparse regression (SGSR): gene-set-based pharmacogenomic predictive models with stepwise selection of functional priors. Jang IS, Dienstmann R, Margolin AA, Guinney J. Pac Symp Biocomput 2015;20:32-43.
  • Intrinsic cancer subtypes – next steps into personalized medicine. Santos C, Sanz-Pamplona R, Nadal E, Grasselli J, Pernas S, Dienstmann R, Moreno V, Tabernero J, Salazar R. Cell Oncol (Dordr) 2015;38(1):3-16.
  • Genomic testing in colorectal cancer: how much is enough? Dienstmann R, Salazar R, Tabernero J. Oncology (Williston Park) 2015;29(3):186-8.
  • A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3. Mau-Sørensen M, Dittrich C, Dienstmann R, Lassen U, Büchler W, Martinius H, Tabernero J. Cancer Chemother Pharmacol 2015;75(5):1065-73.
  • Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors. Dienstmann R, Jang IS, Bot B, Friend S, Guinney J. Cancer Discovery 2015;5(2):118-23.
  • Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients. Dienstmann R, Salazar R, Tabernero J. J Clin Oncol 2015; 33(16):1787-96.
  • Safety and pharmacokinetics/pharmacodynamics of the first-in-class dual action HER3/EGFR antibody MEHD7945A in patients with locally advanced or metastatic epithelial tumors. Juric D, Dienstmann R, Cervantes A, Hidalgo M, Messersmith W, Blumenschein Jr. GR, Tabernero J, Roda D, Calles A, Jimeno A, Wang A, Bohórquez SS, Leddy C, Littman C, Kapp AV, Shames DS, Penuel E, Amler LC, Pirzkall A, Baselga J. Clin Cancer Res 2015;21(11):2462-70.
  • Heterogeneity of driver genes and therapeutic implications in colorectal cancer. Dienstmann R, Cervantes A. Annals Oncol 2015;26(8):1523-5.
  • Overcoming Resistance to anti-EGFR Therapy in Colorectal Cancer. Dienstmann R, Salazar R, Tabernero J. Am Soc Clin Oncol Educ Book 2015;35:e149-56.
  • Safety and activity of the first-in-class Sym004 anti-EGFR antibody mixture in patients with refractory colorectal cancer. Dienstmann R, Patnaik A, Garcia-Carbonero R, Cervantes A, Benavent M, Roselló S, Tops BB, van der Post RS, Argilés G, Skartved NJ, Hansen UH, Hald R, Pedersen MW, Kragh M, Horak ID, Braun S, Van Cutsem E, Tolcher AW, Tabernero J. Cancer Discov 2015;5(6):598-609.
  • Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced solid tumors. Tabernero J, Bahleda R, Dienstmann R, Infante JR, Mita A, Italiano A, Calvo E, Moreno V, Adamo B, Gazzah A, Zhong B, Platero SJ, Smit H, Stuyckens K, Chatterjee-Kishore M, Rodon J, Peddareddigari V, Luo FR, Soria J-C. J Clin Oncol 2015;33(30):3401-8.
  • The consensus molecular subtypes of colorectal cancer. Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S. Nat Med 2015;21(11):1350-6.
  • MEK plus PI3K/mTORC1/2 therapeutic efficacy is impacted by TP53 mutation in preclinical models of colorectal cancer. García-García C, Rivas MA, Ibrahim YH, Calvo MT, Gris-Oliver A, Rodríguez O, Grueso J, Antón P, Guzmán M, Aura C, Nuciforo P, Jessen K, Argilés G, Dienstmann R, Bertotti A, Trusolino L, Matito J, Vivancos A, Chicote I, Palmer HG, Tabernero J, Scaltriti M, Baselga J, Serra V. Clin Cancer Res 2015;21(24):5499-510.
  • Tankyrase inhibition blocks Wnt/β-catenin pathway and reverts resistance to PI3K and AKT inhibitors in the treatment of colorectal cancer. Arques O, Chicote I, Puig I, Tenbaum SP, Argiles G, Dienstmann R, Fernandez N, Caratu G, Matito J, Silberschmidt D, Rodon J, Landolfi S, Prat A, Espin E, Charco R, Nuciforo P, Vivancos A, Shao W, Tabernero J, Palmer HG. Clin Cancer Res 2016;22(3):644-56.
  • First-in-man dose-escalation study of the selective BRAF inhibitor RG7256 in patients with BRAF V600-mutated advanced solid tumors. Dienstmann R, Lassen U, Cebon J, Desai J, Brown MP, Evers S, Su F, Zhang W, Doisserie F, Lestini B, Schostack K, Meresse V, Tabernero J. Target Oncol 2016;11(2):149-56.
  • Nanofluidic Digital PCR and Extended Genotyping of RAS and BRAF for Improved Selection of Metastatic Colorectal Cancer Patients for Anti-EGFR Therapies. Azuara D, Santos C, Lopez-Doriga A, Grasselli J, Nadal M, Sanjuan X, Marin F, Vidal J, Montal R, Moreno V, Bellosillo B, Argiles G, Elez E, Dienstmann R, Montagut C, Tabernero J, Capellá G, Salazar R. Mol Cancer Ther 2016;15(5):1106-12.
  • Spectrum of Gene Mutations in Colorectal Cancer: Implications for Treatment. Dienstmann R, Tabernero J. Cancer J 2016;22(3):149-55.
  • CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer. Griffith M, Spies NC, Krysiak K, Coffman AC, McMichael JF, Ainscough BJ, Rieke DJ, Danos AM, Kujan L, Ramirez CA, Wagner AH, Skidmore ZL, Liu CJ, Jones M, Bilski RL, Lesurf R, Barnell EK, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Karthik G, Eldred JM, Larson DE, Walker JR, Chu S, Bryan JN, Good BN, Wu C, Su AI, Dienstmann R, Jones SJM, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL. Nat Genetics 2017;49(2):170-174.
  • Consensus Molecular Subtyping and the Evolution of Precision Medicine in Colorectal Cancer. Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S, Tabernero J. Nat Rev Cancer 2017;7(2):79-92.
  • Prediction of overall survival in stage II and III colon cancer beyond the American Joint Commission on Cancer TNM system: a retrospective, pooled biomarker study. Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J. Ann Oncol 2017;28(5):1023-1031.
  • Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer. Grasselli J, Elez E, Caratù G, Matito J, Santos C, Macarulla T, Vidal J, Garcia M, Viéitez JM, Paéz D, Falcó E, Lopez Lopez C, Aranda E, Jones F, Sikri V, Nuciforo P, Fasani R, Tabernero J, Montagut C, Azuara D, Dienstmann R, Salazar R, Vivancos A. Ann Oncol 2017 Jun 1;28(6):1294-1301.
  • Pharmacokinetic/Pharmacodynamic Modeling for Drug Development in Oncology. Garralda E, Dienstmann R, Tabernero J. Am Soc Clin Oncol Educ Book 2017;37:210-215.
  • Personalizing Adjuvant Therapy for Stage II/III Colorectal Cancer. McCleary NJ, Benson AB 3rd, Dienstmann R. Am Soc Clin Oncol Educ Book 2017;37:232-245.
  • Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights. Dienstmann R, Elez E, Argiles G, Matos I, Sanz-Garcia E, Ortiz C, Macarulla T, Capdevila J, Alsina M, Sauri T, Verdaguer H, Vilaro M, Ruiz-Pace F, Viaplana C, Garcia A, Landolfi S, Palmer HG, Nuciforo P, Rodon J, Vivancos A, Tabernero J. Mol Oncol 2017;11(9):1263-1272.
  • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells. Roumeliotis TI, Williams SP, Gonçalves E, Alsinet C, Del Castillo Velasco-Herrera M, Aben N, Ghavidel FZ, Michaut M, Schubert M, Price S, Wright JC, Yu L, Yang M, Dienstmann R, Guinney J, Beltrao P, Brazma A, Pardo M, Stegle O, Adams DJ, Wessels L, Saez-Rodriguez J, McDermott U, Choudhary JS. Cell Rep 2017;20(9):2201-2214.
  • Cancer: A precision approach to tumour treatment. Dienstmann R, Tabernero J. Nature 2017;548(7665):40-41.
  • Reply to the letter to the editor ‘Including lynch syndrome in personalized prognostication and follow-up of stage II and III colon cancer’ by Sciallero et al. Dienstmann R, Guinney J. Annals Oncol 2017;28(11)2889-2890.
  • Tumor side as model of integrative molecular classification of colorectal cancer. Dienstmann R. Clin Cancer Res 2018;24(5):989-990.
  • Colorectal cancer Consensus Molecular Subtypes translated to preclinical models uncover potentially targetable cancer-cell dependencies. Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama MA, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA. Clin Cancer Res 2018;24(4):794-806.
  • Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial. Montagut C, Argilés G, Ciardiello F, Poulsen TT, Dienstmann R, Kragh M, Kopetz S, Lindsted T, Ding C, Vidal J, Clausell-Tormos J, Siravegna G, Sánchez-Martín FJ, Koefoed K, Pedersen MW, Grandal MM, Dvorkin M, Wyrwicz L, Rovira A, Cubillo A, Salazar R, Desseigne F, Nadal C, Albanell J, Zagonel V, Siena S, Fumi G, Rospo G, Nadler P, Horak ID, Bardelli A, Tabernero J. JAMA Oncol 2018:e175245.
  • CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer. Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA. Ann Oncol 2018; 29(5):1227-1234
  • Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations. Tamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A, Tusquets I, Albanell J, Rodon J, Tabernero J, de Torres C, Dienstmann R, Gonzalez-Perez A, Lopez-Bigas N. Genome Med 2018;10(1):25.
  • TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence. Puig I, Tenbaum SP, Chicote I, Arqués O, Martínez-Quintanilla J, Cuesta-Borrás E, Ramírez L, Gonzalo P, Soto A, Aguilar S, Eguizabal C, Caratù G, Prat A, Argilés G, Landolfi S, Casanovas O, Serra V, Villanueva A, Arroyo AG, Terracciano L, Nuciforo P, Seoane J, Recio JA, Vivancos A, Dienstmann R, Tabernero J, Palmer HG. J Clin Invest. 2018 Jun 26. pii: 96393.
  • A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations. Tamborero D, Rubio-Perez C, Muiños F, Sabarinathan R, Piulats JM, Muntasell A, Dienstmann R, Lopez-Bigas N, Gonzalez-Perez A. Clin Cancer Res 2018;24(15):3717-3728.
  • Molecular Subtypes and the Evolution of Treatment Decisions in Metastatic Colorectal Cancer. Dienstmann R, Salazar R, Tabernero J. Am Soc Clin Oncol Educ Book 2018;(38):231-238.
  • Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy. Allen WL, Dunne PD, McDade S, Scanlon E, Loughrey M, Coleman H, McCann C, McLaughlin K, Nemeth Z, Syed N, Jithesh P, Arthur K, Wilson R, Coyle V, McArt D, Murray GI, Samuel L, Nuciforo P, Jimenez J, Argiles G, Dienstmann R, Tabernero J, Messerini L, Nobili S, Mini E, Sheahan K, Ryan E, Johnston PG, Van Schaeybroeck S, Lawler M, Longley DB. JCO Precis Oncol 2018; Jun 13
  • Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2. Chang K, Willis JA, Reumers J, Taggart MW, San Lucas FA, Thirumurthi S, Kanth P, Delker DA, Hagedorn CH, Lynch PM, Ellis LM, Hawk ET, Scheet PA, Kopetz S, Arts J, Guinney J, Dienstmann R, Vilar E. Ann Oncol 2018;29(10):2061-2067.
  • A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Mateo J, Chakravarty D, Dienstmann R, Jezdic S, Gonzalez-Perez A, Lopez-Bigas N, Ng CKY, Bedard PL, Tortora G, Douillard JY, Van Allen EM, Schultz N, Swanton C, André F, Pusztai L. Ann Oncol 2018; 29(9):1895-1902
  • Should next-generation sequencing testing be routinely used in metastatic colorectal cancer? Dienstmann R, Ciner A, Hochster HS. Lancet Oncol 2018;19(11):1434-1435
  • Precision oncology: separating the wheat from the chaff. Remon J, Dienstmann R. ESMO Open 2018;3(6):e000446.
  • A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation. Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dienstmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O’Connor MJ, Díez O, Balmaña J, Serra V. EMBO Mol Med 2018;10(12).
  • New clinical trial designs in the era of precision medicine. Garralda E, Dienstmann R, Piris-Giménez A, Braña I, Rodon J, Tabernero J. Mol Oncol 2019;13(3):549-557.
  • Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer. Rodriguez-Freixinos V, Ruiz-Pace F, Fariñas-Madrid L, Garrido-Castro AC, Villacampa G, Nuciforo P, Vivancos A, Dienstmann R, Oaknin A. ESMO Open 2019;4(2):e000444
  • Chemotherapy and PARP inhibitors in heavily pretreated BRCA1/2 mutation ovarian cancer (BMOC) patients. Rodriguez-Freixinos V, Fariñas-Madrid L, Gil-Martin M, Barretina-Ginesta P, Romeo M, Villacampa G, Pardo B, Ahmed H, Recalde S, Piulats JM, Gómez-Plaza MC, Gil-Moreno A, Sala E, Martínez-Román S, Ponce J, Meléndez C, Carballas E, Dienstmann R, Oaknin A. Gynecol Oncol 2019;152(2):270-277.
  • Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer. Serna G, Ruiz-Pace F, Cecchi F, Fasani R, Jimenez J, Thyparambil S, Landolfi S, Elez ME, Vivancos A, Hembrough T, Tabernero J, Dienstmann R, Nuciforo P. Sci Rep 2019;9(1):13568.
  • Predictive modeling in colorectal cancer: time to move beyond consensus molecular subtypes. Sveen A, Cremolini C, Dienstmann R. Ann Oncol 2019;30(11):1682-1685.
  • Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer. Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J. Ann Oncol 2019;30(10):1622-1629.
  • Capturing Hyperprogressive disease with immune checkpoint inhibitors using RECIST 1.1 criteria. Matos I, Martin-Liberal J, Garcia-Ruiz A, Hierro C, Ochoa de Olza M, Viaplana  C, Azaro A, Vieito M, Brana I, Mur G, Ros J, Mateos J, Villacampa G, Berché R, Oliveira M, Alsina M, Élez E, Oaknin A, Muñoz-Couselo E, Carles J, Felip E, Rodon J, Tabernero J, Dienstmann R, Perez-Lopez R, Garralda E. Clin Cancer Res 2020;26(8):1846-1855.
  • Precision Therapy in RAS Mutant Colorectal Cancer. Dienstmann R, Connor K, Byrne AT; COLOSSUS Consortium. Gastroenterology 2020;158(4):806-811.
  • A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer. Wagner AH, Walsh B, Mayfield G, Tamborero D, Sonkin D, Krysiak K, Deu-Pons J, Duren RP, Gao J, McMurry J, Patterson S, Del Vecchio Fitz C, Pitel BA, Sezerman OU, Ellrott K, Warner JL, Rieke DT, Aittokallio T, Cerami E, Ritter DI, Schriml LM, Freimuth RR, Haendel M, Raca G, Madhavan S, Baudis M, Beckmann JS, Dienstmann R, Chakravarty D, Li XS, Mockus S, Elemento O, Schultz N, Lopez-Bigas N, Lawler M, Goecks J, Griffith M, Griffith OL, Margolin AA; Variant Interpretation for Cancer Consortium. Nat Genet 2020;52(4):448-457.
  • Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials. Dienstmann R, Garralda E, Aguilar S, Sala G, Viaplana C, Ruiz-Pace F, González-Zorelle J, Grazia LoGiacco D, Ogbah Z, Ramos Masdeu L, Mancuso F, Fasani R, Jimenez J, Martinez P, Oaknin A, Saura C, Oliveira M, Balmaña J, Carles J, Macarulla T, Elez E, Alsina M, Braña I, Felip E, Tabernero J, Rodon J, Nuciforo P, Vivancos A. JCO Precis Oncol 2020;4:PO.19.00398.
  • Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity. Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok BI, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA. Clin Cancer Res 2020, 26(15):4107-4119.
  • Analysis of mismatch repair (MMR) proteins expression in a series of malignant pleural mesothelioma (MPM) patients. Cedrés S, Ponce-Aix S, Iranzo P, Callejo A, Pardo N, Navarro A, Martinez- Marti A, Gómez-Abecia S, Zucchiatti AC, Sansano I, Enguita AB, Miquel JM, Viaplana C, Dienstmann R, Paz-Ares L, Felip E. Clin Transl Oncol 2020;22(8):1390-1398.
  • Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal. Tamborero D, Dienstmann R, Rachid MH, Boekel J, Baird R, Braña I, De Petris L, Yachnin J, Massard C, Opdam FL, Schlenk R, Vernieri C, Garralda E, Masucci M, Villalobos X, Chavarria E; Cancer Core Europe consortium, Calvo F, Fröhling S, Eggermont A, Apolone G, Voest EE, Caldas C, Tabernero J, Ernberg I, Rodon J, Lehtiö J. Nat Med 2020;26(7):992-994.
  • Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group. Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F. Ann Oncol 2020;S0923-7534(20):39971-3.
  • Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. Gris-Oliver A, Palafox M, Monserrat L, Brasó-Maristany F, Òdena A, Sánchez-Guixé M, Ibrahim YH, Villacampa G, Grueso J, Parés M, Guzmán M, Rodríguez O, Bruna A, Hirst CS, Barnicle A, de Bruin EC, Reddy A, Schiavon G, Arribas J, Mills GB, Caldas C, Dienstmann R, Prat A, Nuciforo P, Razavi P, Scaltriti M, Turner NC, Saura C, Davies BR, Oliveira M, Serra V. Clin Cancer Res 2020 ;26(14):3720-3731.
  • Association of premenopausal risk-reducing salpingo-oophorectomy with breast cancer risk in BRCA1/2 mutation carriers: Maximising bias-reduction. Stjepanovic N, Villacampa G, Nead KT, Torres-Esquius S, Melis GG, Nathanson KL, Teule A, Brunet J, Y Cajal TR, Llort G, Dienstmann R, Rue M, Domchek SM, Balmaña J. Eur J Cancer 2020;132:53-60.
  • Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype. Lupo B, Sassi F, Pinnelli M, Galimi F, Zanella ER, Vurchio V, Migliardi G, Gagliardi PA, Puliafito A, Manganaro D, Luraghi P, Kragh M, Pedersen MW, Horak ID, Boccaccio C, Medico E, Primo L, Nichol D, Spiteri I, Heide T, Vatsiou A, Graham TA, Élez E, Argiles G, Nuciforo P, Sottoriva A, Dienstmann R, Pasini D, Grassi E, Isella C, Bertotti A, Trusolino L. Sci Transl Med 2020;12(555):eaax8313.
  • Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer. Serna G, Ruiz-Pace F, Hernando J, Alonso L, Fasani R, Landolfi S, Comas R, Jimenez J, Elez E, Bullman S, Tabernero J, Capdevila J, Dienstmann R, Nuciforo P. Ann Oncol 2020;31(10):1366-1375.
  • Correlation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer. Zunder SM, Perez-Lopez R, de Kok BM, Raciti MV, van Pelt GW, Dienstmann R, Garcia-Ruiz A, Meijer CA, Gelderblom H, Tollenaar RA, Nuciforo P, Wasser MN, Mesker WE. Eur J Radiol 2020;133:109345.
  • Molecular subtypes and the evolution of treatment management in metastatic colorectal cancer. Martini G, Dienstmann R, Ros J, Baraibar I, Cuadra-Urteaga JL, Salva F, Ciardiello D, Mulet N, Argiles G, Tabernero J, Elez E. Ther Adv Med Oncol 2020;12:1758835920936089.
  • RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon. Yu J, Navickas A, Asgharian H, Culbertson B, Fish L, Garcia K, Olegario JP, Dermit M, Dodel M, Hänisch B, Luo Y, Weinberg EM, Dienstmann R, Warren RS, Mardakheh FK, Goodarzi H. Cancer Discov 2020;10(9):1410-1423.
  • A CT-based Radiomics Signature Is Associated with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors. Ligero M, Garcia-Ruiz A, Viaplana C, Villacampa G, Raciti MV, Landa J, Matos I, Martin-Liberal J, Ochoa-de-Olza M, Hierro C, Mateo J, Gonzalez M, Morales-Barrera R, Suarez C, Rodon J, Elez E, Braña I, Muñoz-Couselo E, Oaknin A, Fasani R, Nuciforo P, Gil D, Rubio-Perez C, Seoane J, Felip E, Escobar M, Tabernero J, Carles J, Dienstmann R, Garralda E, Perez-Lopez R. Radiology 2021:200928.
  • Determinants of COVID-19 Mortality in Patients With Cancer From a Community Oncology Practice in Brazil. Ferrari BL, Ferreira CG, Menezes M, De Marchi P, Canedo J, Melo AC, Jácome AA, Reinert T, Paes RD, Sodré B, Barrios CH, Dienstmann R. JCO Glob Oncol 2021;7:46-55.
  • Dynamics of clinical biomarkers as predictors of immunotherapy benefit in metastatic melanoma patients. Hernando-Calvo A, García-Alvarez A, Villacampa G, Ortiz C, Bodet D, García-Patos V, Recio JA, Dienstmann R, Muñoz-Couselo E. Clin Transl Oncol 2021;23(2):311-317.
  • Minimizing acquisition-related radiomics variability by image resampling and batch effect correction to allow for large-scale data analysis. Ligero M, Jordi-Ollero O, Bernatowicz K, Garcia-Ruiz A, Delgado-Muñoz E, Leiva D, Mast R, Suarez C, Sala-Llonch R, Calvo N, Escobar M, Navarro-Martin A, Villacampa G, Dienstmann R, Perez-Lopez R. Eur Radiol 2021;31(3):1460-1470.
  • PI3K activation promotes resistance to eribulin in HER2-negative breast cancer. Gris-Oliver A, Ibrahim YH, Rivas MA, García-García C, Sánchez-Guixé M, Ruiz-Pace F, Viaplana C, Pérez-García JM, Llombart-Cussac A, Grueso J, Parés M, Guzmán M, Rodríguez O, Anton P, Cozar P, Calvo MT, Bruna A, Arribas J, Caldas C, Dienstmann R, Nuciforo P, Oliveira M, Cortés J, Serra V. Br J Cancer 2021 Mar 15.
  • Evolution of Angiogenic Factors in Pregnant Patients with Breast Cancer Treated with Chemotherapy. Saura C, Sánchez O, Martínez S, Domínguez C, Dienstmann R, Ruíz-Pace F, Céspedes MC, Peñuelas Á, Cortés J, Llurba E, Córdoba O. Cancers (Basel) 2021;13(4):923.
  • EUCANCan: a federated network of aligned and interoperable infrastructures for the homogeneous analysis, management and sharing of genomic oncology data for Personalized Medicine.
  • COLOSSUS: Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions.
  • LEGACy: improving gastric cancer outcomes by applying personalized medicine at the three levels of prevention in Europe and Latin America populations based on an “omics integrative epidemiology” conceptual model.
  • Cancer Core Europe (CCE) Consortium’s Basket of Baskets (BoB).
  • American Association for Cancer Research’s (AACR) Genomics Evidence Neoplasia Information Exchange (GENIE) project.