19th Ave New York, NY 95822, USA

Grupo de Tumores Genitourinarios, del SNC y Sarcomas 

Nuestro ámbito de trabajo es el desarrollo de la investigación clínica y traslacional contra el cáncer, para lo que contamos con una amplia experiencia y conocimientos en el tratamiento de neoplasias diversas. Diseñamos y desarrollamos ensayos clínicos para tumores genitourinarios malignos en distintas fases de la enfermedad en colaboración con urólogos y radioterapeutas.

En los últimos años, varios avances han conducido a un tratamiento más eficaz de las neoplasias malignas genitourinarias (GU). La inmunoterapia (IO) está adquiriendo cada vez más importancia en el tratamiento del cáncer de vejiga y de riñón. En el cáncer de vejiga, la combinación de conjugados anticuerpo-fármaco (ADC) e IO ha cambiado el panorama del tratamiento de primera línea de los pacientes con enfermedad metastásica. Estamos orgullosos de haber participado en el estudio EV-302 (NCT04223856), cuyos resultados demostraron que enfortumab vedotin más pembrolizumab casi duplicaron la mediana de supervivencia global en comparación con la quimioterapia estándar basada en platino.

En el cáncer de riñón, la terapia combinada basada en el sistema inmunitario, o IO más antiangiogénicos, se considera ahora el tratamiento estándar de primera línea. Actualmente estamos estudiando nuevas combinaciones que incluyen inhibidores de HIF2α y otros inmunomoduladores.

En estrecha colaboración con el Servicio de Urología del Hospital Universitario Vall d’Hebron (HUVH), participamos en diferentes estudios de fase I con fármacos dirigidos contra el FGFR. También estamos evaluando ADCs en pacientes con cáncer de vejiga no músculo-invasivo que recaen o progresan a pesar de una terapia intravesical suficiente con Bacillus Calmette-Guerin (BCG), para los que se recomienda una cistectomía radical temprana. Estos nuevos tratamientos, destinados a preservar la vejiga, se administran por vía intravesical.

La teranosis representa un enfoque terapéutico innovador en el cáncer de próstata basado en la administración de radioligandos mediante emisores beta. Actualmente se están desarrollando nuevos radioligandos que utilizan emisores α. Hemos participado en ensayos de fase III con pacientes de cáncer de próstata metastásico no hormonados y resistentes a la castración. Este tipo de terapia requiere una estrecha colaboración con los equipos de medicina nuclear para coordinar la administración y el seguimiento de los pacientes.

También en colaboración con el Departamento de Urología del HUVH, hemos participado en estudios recientes que han demostrado la utilidad de los inhibidores de puntos de control inmunitarios (ICI) en el contexto adyuvante para pacientes con cáncer de vejiga y riñón con alto riesgo de recurrencia de la enfermedad.

También colaboramos con otros centros de investigación de renombre, como la Clínica Cleveland (Ohio, EE.UU.), la Universidad de California en San Francisco (California, EE.UU.), y participamos en estudios realizados en colaboración con el Instituto Gustave Roussy (París, Francia), el Barts Health NHS Trust – Hospital (Londres, Reino Unido) y el Kantonsspital St. Gallen (Suiza).

Este año hemos seguido ampliando nuestro programa de investigación traslacional en cáncer de próstata, colaborando con el Grupo de Investigación Traslacional en Cáncer de Próstata del VHIO, dirigido por Joaquín Mateo, así como con otros hospitales de Cataluña.

También estamos desarrollando nuevos métodos para identificar características tumorales utilizando exosomas, y seguimos participando en el proyecto IRONMAN dirigido por el Memorial Sloan Kettering Cancer Center (MSKCC – Nueva York, EE.UU.), como repositorio nacional español. Este registro internacional está construyendo un completo banco de datos clínicos y bioespecímenes de pacientes con cáncer de próstata metastásico. Nuestra participación en este proyecto cuenta con el apoyo de la Movember Foundation y la Fundación FERO.

En marzo de este año, pusimos en marcha un proyecto de colaboración con el Grupo SOLTI y las sociedades de cáncer de próstata de España, centrado en capacitar a los pacientes con cáncer de próstata metastásico resistente a la castración (CPRCm). Para facilitarlo, hemos desarrollado un sitio web específico que integra la secuenciación de próxima generación (NGS) de muestras tumorales y datos de biopsia líquida obtenidos a través de la plataforma Guardant Health. Como parte de nuestra iniciativa, solicitamos a los pacientes que participen en una encuesta para evaluar sus expectativas antes y después del análisis NGS. Este feedback nos ayuda a conocer su percepción sobre los tratamientos recomendados por un panel de especialistas. Este estudio está avalado por la Asociación Española Contra el Cáncer (AECC) y la Fundación Movember. En el primer año del proyecto, hemos reclutado a más de 100 pacientes.

En colaboración con el Grupo de Radiómica del VHIO liderado por Raquel Pérez-López, hemos iniciado otro nuevo proyecto utilizando PET MRI para definir biomarcadores de respuesta basados en imagen funcional en cáncer de próstata. Este estudio está financiado por el Programa RETOS del Ministerio de Ciencia español.

Iniciado en mayo de este año, CARE1 es un proyecto europeo coordinado por Gustave Roussy. Centrado en ensayos clínicos pragmáticos y aprovechando una red académica europea única, CARE 1 tiene como objetivo mejorar el tratamiento de primera línea de los pacientes con cáncer renal metastásico mediante la implementación de un biomarcador de rutina. Nuestra participación en este proyecto cuenta con el apoyo de la CRIS Cancer Foundation y del programa de investigación e innovación Horizon Europe de la UE.

Financiado por la Sociedad Española de Oncología Médica (SEOM), coordinamos un estudio nacional para identificar biomarcadores predictivos de respuesta al tratamiento de primera línea del carcinoma de células renales (CCR). Financiado por una subvención recibida del Grupo Español de Oncología Genitourinaria (SOGUG), también participamos en un proyecto dedicado al análisis de biopsias tumorales paritarias.

En 2023, lanzamos el ensayo CHECKYMID para investigar prospectivamente el papel y la seguridad de la IO en el tratamiento de pacientes con cáncer (CCR, vejiga, pulmón o melanoma) y afectados por enfermedades inflamatorias inmunomediadas (IMID). Coordinamos este estudio en colaboración con los equipos de reumatología, digestivo y dermatología del HUVH.

Somos fundadores y coordinadores del Grupo de Trabajo de Adolescentes del grupo cooperativo español GEINO para la investigación en neuro-oncología, y hemos participado en las primeras guías clínicas GEINO-SEOM para el meduloblastoma del adulto.

Nuestro Banco de Sueros incluye ya la mayoría de los tipos tumorales que estudiamos (tumores del SNC, GIST; carcinoma de células renales y CPRC), y seguiremos recogiendo muestras de nuestros pacientes.

Hemos puesto en marcha la primera Unidad de Adolescentes y Adultos Jóvenes (AYAs) en España para pacientes entre 16 y 25 años. Este programa recoge datos para el desarrollo de nuevos tratamientos para tumores que aparecen durante la edad adulta pero que se observan predominantemente en poblaciones pediátricas, y viceversa. Dirigida por oncólogos pediátricos y de adultos, esta Unidad está tratando inicialmente a pacientes con tumores del SNC, sarcoma y tumores testiculares, pero también pretende incluir otros tipos de tumores y avanzar en el conocimiento de la toxicidad de la terapia tardía del cáncer.

En cuanto a los tumores de primario desconocido (CUP), estamos trabajando con investigadores del Instituto de Investigación contra la Leucemia Josep Carreras dirigidos por Manel Esteller. Utilizando la multiómica (genómica, transcriptómica y epigenómica) para caracterizar las características moleculares de 500 casos de cáncer de CUP, pretendemos profundizar en el conocimiento de los mecanismos moleculares que rigen el desarrollo de estos tumores. Con el apoyo del Instituto de Salud Carlos III (ISCIII), también lideramos y coordinamos el programa de medicina de precisión IMPaCT-GENóMICA para avanzar en el diagnóstico de los tumores CUP.

Dedicados a promover la educación y el intercambio, en 2023 acogimos a siete becarios de España y del extranjero para estancias cortas de 3 meses.

Joan Carles
Jefe de grupo
Rafael_Morales
Rafael Morales
Investigador sénior
Cristina_Suárez
Cristina Suárez
Investigadora sénior
Claudia_Valverde
Claudia Valverde
Investigadora sénior
  • Diseñar y desarrollar ensayos clínicos que abarcan todos los tumores malignos estudiados por nuestro grupo. Pretendemos proporcionar a nuestros pacientes los mejores y más innovadores tratamientos, como pueden ser tratamientos a partir de inmunoterapia, tratamientos dirigidos y nuevas quimioterapias.
  • Llevar a cabo ensayos clínicos en diferentes fases de la enfermedad con especial atención a un diseño adaptado a la histología y un planteamiento multidisciplinar.
  • Consolidar nuestro programa de biopsias (principalmente en hueso) en el caso de pacientes con cáncer de próstata metastásico resistente a la castración (CPRCm) para abordar alteraciones genómicas como las alteraciones en las rutas PI3K, los genes de reparación del ADN y los receptores androgénicos.
  • Seguir consolidando nuestra plantilla de colaboradores en el ámbito del cáncer de riñón en el VHIO en colaboración con investigadores del Vall d’Hebron Instituto de Investigación (VHIR) y el Instituto de Investigación Biomédica de Bellvitge (IDIBELL).
  • Llevar a cabo estudios de la microbiota como biomarcador para inmunoterapias a fin de tratar los tumores malignos de vejiga y riñón.
  • Ampliar nuestra plataforma de investigación traslacional sobre el glioblastoma en colaboración con el Grupo de Expresión Génica y Cáncer del VHIO.
  • Desarrollar nuestra plataforma traslacional sobre el tumor del estroma gastrointestinal (GIST) y ampliar la investigación en colaboración con el Grupo Español de Investigación en Sarcomas (GEIS) y otros centros europeos de referencia. También somos un miembro activo de la Red Europea de Referencia (ERN).
  • Desarrollar nuevas herramientas y técnicas, como la biopsia líquida, para nuestros pacientes, con el fin de adaptar de manera más precisa los tratamientos contra el CPRCm, el GIST y el cáncer de riñón.
Jefe de grupo
Joan Carles
Oncólogos médicos y asistentes clínicos
Carlo Cicala, Macarena González, David Marmolejo, Rafael Morales, César Serrano, Cristina Suárez, Claudia Valverde, María Vieito, Joaquin Mateo
Enfermería clínica especializada
Alexandre Sierra, Anna Vázquez

Publicaciones científicas más relevantes

  • Pook D, Geynisman DM, Carles J, de Braud F, Joshua AM, Pérez-Gracia JL, Llácer Pérez C, Shin SJ, Fang B, Barve M, Maruzzo M, Bracarda S, Kim M, Kerloeguen Y, Gallo JD, Maund SL, Harris A, Huang KC, Poon V, Sutaria DS, Gurney H. A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer. Clin Cancer Res. 2023 Sep 1;29(17):3292-3300.
  • Agarwal N, Azad AA, Carles J, Fay AP, Matsubara N, Heinrich D, Szczylik C, De Giorgi U, Young Joung J, Fong PCC, Voog E, Jones RJ, Shore ND, Dunshee C, Zschäbitz S, Oldenburg J, Lin X, Healy CG, Di Santo N, Zohren F, Fizazi K. Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial. Lancet. 2023 Jul 22;402(10398):291-303.
  • Carles J, Medina-Lopez RA, Puente J, Gómez-Ferrer Á, Nebra JC, Sáez Medina MI, Ribal MJ, Antolín AR, Álvarez-Ossorio JL, Suárez Novo JF, Agut CM, Srinivasan S, Ortiz J, Fizazi K. Darolutamide in Spanish patients with nonmetastatic castration-resistant prostate cancer: ARAMIS subgroup analysis. Future Oncol. 2023 Apr;19(12):819-828.
  • Yu EY, Piulats JM, Gravis G, Fong PCC, Todenhöfer T, Laguerre B, Arranz JA, Oudard S, Massard C, Heinzelbecker J, Nordquist LT, Carles J, Kolinsky MP, Augustin M, Gurney H, Tafreshi A, Li XT, Qiu P, Poehlein CH, Schloss C, de Bono JS. Pembrolizumab plus Olaparib in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort A Study. Eur Urol. 2023 Jan;83(1):15-26.
  • Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. Lancet. 2022 Apr 30;399(10336):1695-1707.
  • Agarwal N, Azad A, Carles J, Chowdhury S, McGregor B, Merseburger AS, Oudard S, Saad F, Soares A, Benzaghou F, Kerloeguen Y, Kimura A, Mohamed N, Panneerselvam A, Wang F, Pal S. A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer. Future Oncol. 2022 Mar;18(10):1185-1198.
  • Suarez C, Marmolejo D, Valdivia A, Morales-Barrera R, Gonzalez M, Mateo J, Semidey ME, Lorente D, Trilla E, Carles J. Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease. Front Oncol. 2022 Oct 4;12:970199.
  • Carles J, Alonso-Gordoa T, Mellado B, Méndez-Vidal MJ, Vázquez S, González-Del-Alba A, Piulats JM, Borrega P, Gallardo E, Morales-Barrera R, Paredes P, Reig O, Garcías de España C, Collado R, Bonfill T, Suárez C, Sampayo-Cordero M, Malfettone A, Garde J. Radium-223 for patients with metastatic castration-resistant prostate cancer with asymptomatic bone metastases progressing on first-line abiraterone acetate or enzalutamide: A single-arm phase II trial. Eur J Cancer. 2022 Sep;173:317-326.
  • Sternberg CN, Castellano D, de Bono J, Fizazi K, Tombal B, Wülfing C, Kramer G, Eymard JC, Bamias A, Carles J, Iacovelli R, Melichar B, Sverrisdóttir Á, Theodore C, Feyerabend S, Helissey C, Poole EM, Ozatilgan A, Geffriaud-Ricouard C, de Wit R. Efficacy and Safety of Cabazitaxel Versus Abiraterone or Enzalutamide in Older Patients with Metastatic Castration-resistant Prostate Cancer in the CARD Study. Eur Urol. 2021 Oct;80(4):497-506.
  • Neeb A, Herranz N, Arce-Gallego S, Miranda S, Buroni L, Yuan W, Athie A, Casals T, Carmichael J, Rodrigues DN, Gurel B, Rescigno P, Rekowski J, Welti J, Riisnaes R, Gil V, Ning J, Wagner V, Casanova-Salas I, Cordoba S, Castro N, Fenor de la Maza MD, Seed G, Chandran K, Ferreira A, Figueiredo I, Bertan C, Bianchini D, Aversa C, Paschalis A, Gonzalez M, Morales-Barrera R, Suarez C, Carles J, Swain A, Sharp A, Gil J, Serra V, Lord C, Carreira S, Mateo J, de Bono JS. Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. Eur Urol. 2021 Feb;79(2):200-211.
  • Powles T, Carroll D, Chowdhury S, Gravis G, Joly F, Carles J, Fléchon A, Maroto P, Petrylak D, Rolland F, Cook N, Balar AV, Sridhar SS, Galsky MD, Grivas P, Ravaud A, Jones R, Cosaert J, Hodgson D, Kozarewa I, Mather R, McEwen R, Mercier F, Landers D. An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nat Med. 2021 May;27(5):793-801.
  • Suárez C, Díaz-Mejía N, Morales-Barrera R, González M, Mateo J, Carles J. Metastatic nonclear renal cell carcinoma current review in evolving treatment strategies. Curr Opin Urol. 2021 May 1;31(3):242-248.
  • Mateo J, Porta N, Bianchini D, McGovern U, Elliott T, Jones R, Syndikus I, Ralph C, Jain S, Varughese M, Parikh O, Crabb S, Robinson A, McLaren D, Birtle A, Tanguay J, Miranda S, Figueiredo I, Seed G, Bertan C, Flohr P, Ebbs B, Rescigno P, Fowler G, Ferreira A, Riisnaes R, Pereira R, Curcean A, Chandler R, Clarke M, Gurel B, Crespo M, Nava Rodrigues D, Sandhu S, Espinasse A, Chatfield P, Tunariu N, Yuan W, Hall E, Carreira S, de Bono JS. Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2020 Jan;21(1):162-174. Clinical Trial.
  • Matos I, Martin-Liberal J, Garcia-Ruiz A, Hierro C, Ochoa de Olza M, Viaplana C, Azaro A, Vieito M, Braña I, Mur G, Ros J, Mateos J, Villacampa G, Berche R, Oliveira M, Alsina M, Elez E, Oaknin Ana, Munoz-Couselo E, Carles J, Felip E, Rodon J, Tabernero J, Dienstmann R, Perez-Lopez R, Garralda E. Capturing Hyperprogressive Disease with Immune-Checkpoint Inhibitors Using RECIST 1.1 Criteria. Clin Cancer Res. 2020 Apr 15;26(8):1846-1855.
  • Morales-Barrera R, Suárez C, González M, Valverde C, Serra E, Mateo J, Raventos C, 03 Maldonado X, Morote J, Carles J. The future of bladder cancer therapy: Optimizing the inhibition of the fibroblast growth factor receptor. Cancer Treat Rev. 2020 Jun; 86. Article 102000.
  • Fizazi K, Kramer G, Eymard JC, Sternberg CN, de Bono J, Castellano D, Tombal B, Whuelfing C, Liontos M, Carles J, Iacovelli R, Melichar B, Sverrisdottir A, Theodore C, Eyerabend S, Helissey C, Oudard S, Facchini G, Poole EM, Ozatilgan A, Geffriaud-Ricouard C, Bensfia S, de Wit R. Quality of life in patients with metastatic prostate cancer following treatment with cabazitaxel versus abiraterone or enzalutamide (CARD): an analysis of a randomised, multicentre, open-label, phase 4 study. Lancet Oncol. 2020 Nov;21(11):1513-1525.
  • De Wit R, De Bono J, Sternberg CN, Fizazi K, Tombal B, Wulfing C, Kramer G, Eymard JC, Bamias A, Carles J, Iacovelli R, Melichar B, Sverrisdottir A, Theodore C, Feyerabend S, Helissey C, Ozatilgan A, Geffriaud-Ricouard C, Castellano D, CARD Investigators. Cabazitaxel versus abiraterone or enzalutamide in metastatic prostate cancer. N Engl J Med. 2019 Dec 26;381(26):2506-2518.
  • Slovin S, Clark W, Carles J, Krivoshik A, Park JW, Wang F, George D. Seizure Rates in Enzalutamide-Treated Men With Metastatic Castration-Resistant Prostate Cancer and Risk of Seizure: The UPWARD Study. JAMA Oncol. 2018 May 4(5): 702-706.
  • Carles J, Castellano D, Mendez-Vidal MJ, Mellado B, Saez MI, Gonzalez del Alba A, Perez-Gracia JL, Jimenez J, Suarez C, Sepulveda JM, Manneh R, Porras I, Lopez C, Morales-Barrera R, Arranz JA. Circulating tumor cells as a biomarker of survival and response to Radium-223 therapy: Experience in a cohort of patients with metastatic castration-resistant prostate cancer. Clin Genitourin Cancer. 2018 Dec;16(6):e1133-e1139.
  • Miller K, Carles J, Gschwend JE, Van Poppel H, Diels J, Brookman-May SD. The Phase 3 COU-AA-302 Study of Abiraterone Acetate Plus Prednisone in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Stratified Analysis Based on Pain, Prostate-specific Antigen, and Gleason Score. Eur Urol. 2018 Jul 74 (1): 17-23.
  • Carles J, Pichler A, Korunkova H, Tomova A, Ghosn M, El Karak F, Makdessi J, Koroleva I, Barnes G, Bury D, Ozatilgan A, Hitier S, Katolicka J. An observational, multicentre study of cabazitaxel in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (CAPRISTANA). BJU Int. 2019 Mar;123(3):456-464. Epub 2018 Sep 16.
  • Eisenberger M, Hardy-Bessard AC, Kim CS, Géczi L, Ford D, Mourey L, Carles J, Parente P, Font A, Kacso G, Chadjaa M, Zhang W, Bernard J, de Bono J. Phase III Study Comparing a Reduced Dose of Cabazitaxel (20 mg/m2) and the Currently Approved Dose (25 mg/m2) in Postdocetaxel Patients With Metastatic Castration-Resistant Prostate Cancer-PROSELICA. J Clin Oncol. 2017 Oct 1;35(28):3198-3206.
  • García-Donas J, Font A, Pérez-Valderrama B, Virizuela JA, Climent MÁ, Hernando-Polo S, Arranz JÁ, Del Mar Llorente M, Lainez N, Villa-Guzmán JC, Mellado B, Del Alba AG, Castellano D, Gallardo E, Anido U, Del Muro XG, Domènech M, Puente J, Morales-Barrera R, Pérez-Gracia JL, Bellmunt J. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial. Lancet Oncol. 2017 May;18(5):672-681.
  • Necchi A, Sonpavde G, Lo Vullo S, Giardiello D, Bamias A, Crabb SJ, Harshman LC, Bellmunt J, De Giorgi U, Sternberg CN, Cerbone L, Ladoire S, Wong YN, Yu EY, Chowdhury S, Niegisch G, Srinivas S, Vaishampayan UN, Pal SK, Agarwal N, Alva A, Baniel J, Golshayan AR, Morales-Barrera R, Bowles DW, Milowsky MI, Theodore C, Berthold DR, Daugaard G, Sridhar SS, Powles T, Rosenberg JE, Galsky MD, Mariani L; RISC Investigators. Nomogram-based Prediction of Overall Survival in Patients with Metastatic Urothelial Carcinoma Receiving First-line Platinum-based Chemotherapy: Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC). Eur Urol. 2017 Feb;71(2):281-289.
  • Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A. A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors. Cancer Discov.2017 Jan;7(1):102-113.
  • Saad F, Carles J, Gillessen S, Heidenreich A, Heinrich D, Gratt J, Lévy J, Miller K, Nilsson S, Petrenciuc O, Tucci M, Wirth M, Federhofer J, O’Sullivan JM; Radium-223 International Early Access Program Investigators. Radium-223 and concomitant therapies in patients with metastatic castration-resistant prostate cancer: an international, early access, open-label, single-arm phase 3b trial. Lancet Oncol. 2016 Sep;17(9):1306-16.
  • Moran S, Martínez-Cardús A, Sayols S, Musulén E, Balañá C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Miró M, Matias-Guiu X, Pazo-Cid R, Antón A, Lopez-Lopez R, Soler G, Longo F, Guerra I, Fernandez S, Assenov Y, Plass C, Morales R, Carles J, Bowtell D, Mileshkin L, Sia D, Tothill R, Tabernero J, Llovet JM, Esteller M. Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. Lancet Oncol. 2016 Oct;17(10):1386-1395.
  • Jiménez-Valerio G, Martínez-Lozano M, Bassani N, Vidal A, Ochoa-de-Olza M, Suárez C, García-Del-Muro X, Carles J, Viñals F, Graupera M, Indraccolo S, Casanovas O. Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients. Cell Rep. 2016 May 10;15(6):1134-43.
  • Morales-Barrera R, Suárez C, de Castro AM, Racca F, Valverde C, Maldonado X, Bastaros JM, Morote J, Carles J. Targeting fibroblast growth factor receptors and immune checkpoint inhibitors for the treatment of advanced bladder cancer: New direction and New Hope. Cancer Treat Rev. 2016 Nov; 50: 208-216.
  • Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Srinivas S, Morales-Barrera R, Carles J, Al-Wardat R, Al-Rabi K, Maakoseh M.  Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model. Clin Genitourin Cancer 2016 Jun; 14(3): 255-60
  • Serrano C, Romagosa C, Hernandez-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Verges R, Domínguez R, Carles J, Ramón y Cajal S.  RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Cancer 2016 Jan; 122(1): 99-107
  • Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE.  Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015 Feb; 16(2): 152-60
  • De Mattos-Arruda L, Mayor R, Ng CK, Weigelt B, Martínez-Ricarte F, Torrejón D, Oliveira M, Arias A, Raventós C, Tang J, Guerini-Rocco E, Martínez-Sáez E, Lois S, Marín O, de la Cruz X, Piscuoglio S, Towers R, Vivancos A, Peg V, Ramón y Cajal S, Carles J, Rodón J, González-Cao M, Tabernero J, Felip E, Sahuquillo J, Berger MF, Cortes J, Reis-Filho JS, Seoane J.  Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat Commun 2015; 6: 8839
  • Smith MR, Rathkopf DE, Mulders PF, Carles J, Van Poppel H, Li J, Kheoh T, Griffin TW, Molina A, Ryan CJ.  Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. J. Urol. 2015 Nov; 194(5): 1277-84
  • Suárez C, Morales-Barrera R, Ramos V, Nuñez I, Valverde C, Planas J, Morote J, Maldonado X, Carles J.  Role of immunotherapy in castration-resistant prostate cancer (CRPC). BJU Int. 2014 Mar; 113(3): 367-75
  • Morales-Barrera R, Suárez C, Valverde C, Nuñez I, Maldonado X, Morote J, Carles J.  Do patients with metastatic urothelial carcinoma benefit from docetaxel as second-line chemotherapy? Clin Transl Oncol 2014 Jan; 16(1): 102-6
  • Simonetti S, Serrano C, Hernandez-Losa J, Bagué S, Orellana R, Valverde C, Lleonart ME, Aizpurua M, Carles J, Ramón y Cajal S, Romagosa C.  Schwannomas, benign tumors with a senescent phenotype.Histol. Histopathol. 2014 Jun; 29(6): 721-30
  • Prior C, Pérez-Gracia JL, García-Donas J, Rodriguez-Antona C, Guruceaga E, Esteban E, Suárez C, Castellano D, del Alba AG, Lozano MD, Carles J, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Gurpide A, Lopez-Picazo JM, Hernandez AG, Mellado B, Martínez E, Moreno F, Font A, Calvo A.  Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS ONE 2014; 9(1): e86263

Todas las publicaciones

  • DM Geynisman; M Burotto; C Porta; C Suarez; MT Bourlon; V Del Tejo; EX Du; X Yang; SR Sendhil; KA Betts; S Huo. Grade 3/4 Adverse Event Costs of Immuno-oncology Combination Therapies for Previously Untreated Advanced Renal Cell Carcinoma. Oncologist.28 – 1, pp. 72 – 79. 18/01/2023. ISSN 1549490X. DOI: 10.1093/oncolo/oyac186
  • Matthew S. Ernst; Vishal Navani; J. Connor Wells; Frede Donskov; Naveen Basappa; Chris Labaki; Sumanta K. Pal; Luis Meza; Lori A. Wood; D. Scott Ernst; Bernadett Szabados; Rana R. McKay; Francis Parnis; Cristina Suarez; Takeshi Yuasa; Aly-Khan Lalani; Ajjai Alva; Georg A Bjarnason; Toni K. Choueiri; Daniel Y.C. Henga. Outcomes for International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Groups in Contemporary First-line Combination Therapies for Metastatic Renal Cell Carcinoma.  European Urology. 26/01/2023. ISSN 0302-2838. DOI: 10.1016/j.eururo.2023.01.001
  • Suarez, Cristina; Vieito, Maria; Valdivia, Augusto; Gonzalez, Macarena; Carles, Joan. Selective HIF2A Inhibitors in the Management of Clear Cell Renal Cancer and Von Hippel-Lindau-Disease-Associated Tumors. Med Sci (Basel, Switzerland). 11 – 3, 01/01/2023. ISSN 2076-3271
  • Pestana RC, Serrano C.  Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database. Front Oncol. 2023 Jan 18;12:1079909. doi: 10.3389/fonc.2022.1079909. eCollection 2022.
  • RJ Motzer; M Schmidinger; M Eto; C Suarez; R Figlin; Y Liu; R Perini; Y Zhang; DY. Heng. LITESPARK-011: Belzutifan plus lenvatinib vs cabozantinib in advanced renal cell carcinoma after anti-PD-1/PD-L1 therapy. Future Oncol.08/02/2023. ISSN 1479-6694. DOI: 10.2217/fon-2022-0802
  • Yu, Evan Y.; Piulats, Josep M.; Gravis, Gwenaelle; Fong, Peter C. C.; Todenhoefer, Tilman; Laguerre, Brigitte; Arranz, Jose A.; Oudard, Stephane; Massard, Christophe; Heinzelbecker, Julia; Nordquist, Luke T.; Carles, Joan; Kolinsky, Michael P.; Augustin, Marinela; Gurney, Howard; Tafreshi, Ali; Li, Xin Tong; Qiu, Ping; Poehlein, Christian H.; Schloss, Charles; de Bono, Johann S.Pembrolizumab plus Olaparib in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort A Study (vol 83, pg 15, 2023). Eur Urol. 83 – 3, pp. E87 – E87. 16/02/2023. ISSN 0302-2838, ISSN 1873-7560
  • Moreno V, Vieito M, Sepulveda JM, Galvao V, Hernández-Guerrero T, Doger B, Saavedra O, Carlo-Stella C, Michot JM, Italiano A, Magagnoli M, Carpio C, Pinto A, Sarmiento R, Amoroso B, Aronchik I, Filvaroff E, Hanna B, Wei X, Nikolova Z, Braña I. BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas. Nat Commun. 2023 Mar 13;14(1):1359. doi: 10.1038/s41467-023-36976-1. PMID: 36914652 Free PMC article. Clinical Trial.
  • He W, Xu L, Ding J, Song L, Yang W, Klooster I, Pilco-Janeta DF, Serrano C, Fang H, Jiang G, Wang X, Yu J, Ou WB. Co-targeting of ACK1 and KIT triggers additive anti-proliferative and -migration effects in imatinib-resistant gastrointestinal stromal tumors. Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166690. doi: 10.1016/j.bbadis.2023.166690. Epub 2023 Mar 13.
  • Gillessen S, Bossi A, Davis ID, de Bono J, Fizazi K, James ND, Mottet N, Shore N, Small E, Smith M, Sweeney CJ, Tombal B, Antonarakis ES, Aparicio AM, Armstrong AJ, Attard G, Beer TM, Beltran H, Bjartell A, Blanchard P, Briganti A, Bristow RG, Bulbul M, Caffo O, Castellano D, Castro E, Cheng HH, Chi KN, Chowdhury S, Clarke CS, Clarke N, Daugaard G, De Santis M, Duran I, Eeles R, Efstathiou E, Efstathiou J, Ekeke ON, Evans CP, Fanti S, Feng FY, Fonteyne V, Fossati N, Frydenberg M, George D, Gleave M, Gravis G, Halabi S, Heinrich D, Herrmann K, Higano C, Hofman MS, Horvath LG, Hussain M, Jereczek-Fossa BA, Jones R, Kanesvaran R, Kellokumpu-Lehtinen PL, Khauli RB, Klotz L, Kramer G, Leibowitz R, Logothetis C, Mahal B, Maluf F, Mateo J, Matheson D, Mehra N, Merseburger A, Morgans AK, Morris MJ, Mrabti H, Mukherji D, Murphy DG, Murthy V, Nguyen PL, Oh WK, Ost P, O’Sullivan JM, Padhani AR, Pezaro CJ, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin MA, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Sharifi N, Skoneczna I, Soule H, Spratt DE, Srinivas S, Sternberg CN, Steuber T, Suzuki H, Sydes MR, Taplin ME, Tilki D, Türkeri L, Turco F, Uemura H, Uemura H, Ürün Y, Vale CL, van Oort I, Vapiwala N, Walz J, Yamoah K, Ye D, Yu EY, Zapatero A, Zilli T, Omlin A. Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022. Eur J Cancer. 2023 May;185:178-215. doi: 10.1016/j.ejca.2023.02.018. Epub 2023 Mar 3. PMID: 37003085.
  • Moreno V, Vieito M, Sepulveda JM, Galvao V, Hernández-Guerrero T, Doger B, Saavedra O, Carlo-Stella C, Michot JM, Italiano A, Magagnoli M, Carpio C, Pinto A, Sarmiento R, Amoroso B, Aronchik I, Filvaroff E, Hanna B, Wei X, Nikolova Z, Braña I. BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas. Nat Commun. 2023 Mar 13;14(1):1359. doi: 10.1038/s41467-023-36976-1. PMID: 36914652 Free PMC article. Clinical Trial.
  • Pérez-Fidalgo JA, Ortega E, Ponce J, Redondo A, Sevilla I, Valverde C, Isern Verdum J, de Alava E, Galera López M, Marquina G, Sebio A. Uterine sarcomas: clinical practice guidelines for diagnosis, treatment, and follow-up, by Spanish group for research on sarcomas (GEIS). Ther Adv Med Oncol. 2023 Mar 28;15:17588359231157645. doi: 10.1177/17588359231157645. PMID: 37007636; PMCID: PMC10052607.
  • T Powles; M Kockx; A Rodriguez-Vida; I Duran; SJ Crabb; MS Van Der Heijden; B Szabados; AF Pous; G Gravis; UA Herranz; A Protheroe; A Ravaud; D Maillet; MJ Mendez; C Suarez; M Linch; A Prendergast; PJ van Dam; D Stanoeva; S Daelemans; S Mariathasan; JS Tea; K Mousa; R Banchereau; D Castellano. Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial. Nat Med. 29 – 12, pp. 3271. 21/03/2023. DOI: 10.1038/s41591-019-0628-7
  • C Loo Gan; J Huang; E Pan; W Xie; AL Schmidt; C Labaki; L Meza; G Bouchard; H Li; F Jackson-Spence; C Sánchez-Ruiz; T Powles; SA Kumar; N Weise; WA Hall; BS Rose; B Beuselinck; C Suarez; SK Pal; TK Choueiri; DYC Heng; RR. McKay. Real-world Practice Patterns and Safety of Concurrent Radiotherapy and Cabozantinib in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium. Eur Urol Oncol. 6 – 2, pp. 204 – 211. 01/04/2023. DOI: 10.1016/j.euo.2022.10.004
  • Serrano C, Bauer S, Gómez-Peregrina D, Kang YK, Jones RL, Rutkowski P, Mir O, Heinrich MC, Tap WD, Newberry K, Grassian A, Shi H, Bialick S, Schöffski P, Pantaleo MA, von Mehren M, Trent JC, George S. Circulating tumor DNA analysis of the phase III VOYAGER trial: KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib.  Ann Oncol. 2023 Jul;34(7):615-625. doi: 10.1016/j.annonc.2023.04.006. Epub 2023 Apr 25.
  • Ruiz-Demoulin S, Trenquier E, Dekkar S, Deshayes S, Boisguérin P, Serrano C, de Santa Barbara P, Faure S. LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib. Int J Mol Sci. 2023 Apr 12;24(8):7138. doi: 10.3390/ijms24087138.
  • Carles, Joan; Medina-Lopez, Rafael A.; Puente, Javier; Gomez-Ferrer, Alvaro; Nebra, Javier Casas; Medina, Maria Isabel Saez; Ribal, Maria J.; Antolin, Alfredo Rodriguez; Alvarez-Ossorio, Jose Luis; Novo, Jose Francisco Suarez; Agut, Cristina Moretones; Srinivasan, Shankar; Ortiz, Jorge; Fizazi, Karim. Darolutamide in Spanish patients with nonmetastatic castration-resistant prostate cancer: ARAMIS subgroup analysis. Fut Oncol. 19 – 12, pp. 819 – 828. Fut Med LTD, 24/05/2023. ISSN 1479-6694, ISSN 1744-8301
  • Morales-Barrera, Rafael; Villacampa, Guillermo; Vidal, Natalia; Figols, Mariona; Giner, Julia; Bonfill, Teresa; Suarez, Cristina; Diaz, Nely; Mateo, Joaquin; Gonzalez, Macarena; Domenech, Montserrat; Puente, Javier; Carles, Joan. Prevalence of immune-related adverse events and anti-tumor efficacy in advanced/metastatic urothelial carcinoma following immune-checkpoint inhibitor treatment. Clin & Trans Oncol. 25 – 12, pp. 3556 – 3564. SPRINGER INT PUBL AG, 22/05/2023. ISSN 1699-048X, ISSN 1699-3055
  • C Suárez; JMG Larkin; P Patel; BP Valderrama; A Rodriguez-Vida; H Glen; F Thistlethwaite; C Ralph; G Srinivasan; MJ Mendez-Vidal; R Hartmaier; A Markovets; A Prendergast; B Szabados; K Mousa; T Powles. Phase II Study Investigating the Safety and Efficacy of Savolitinib and Durvalumab in Metastatic Papillary Renal Cancer (CALYPSO). J Clin Oncol.41 – 14, pp. 2493 – 2502. 10/05/2023. ISSN 2394-6520. DOI: 10.1200/JCO.22.01414
  • Hernando-Calvo A, Mirallas O, Marmolejo D, Saavedra O, Vieito M, Assaf Pastrana JD, Aguilar S, Bescós C, Lorente J, Giralt J, Benavente S, Temprana-Salvador J, Alberola M, Dienstmann R, Garralda E, Felip E, Villacampa G, Brana I. Nutritional status associates with immunotherapy clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma patients. Oral Oncol. 2023 May;140:106364. doi: 10.1016/j.oraloncology.2023.106364. Epub 2023 Mar 28. PMID: 36989964 Free article.
  • TK Choueiri; T Powles; L Albiges; M Burotto; C Szczylik; B Zurawski; E Yanez Ruiz; M Maruzzo; A Suarez Zaizar; LE Fein; FA Schutz; DYC Heng; F Wang; F Mataveli; YL Chang; M van Kooten Losio; C Suarez; RJ Motzer. Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma. N. Engl J Med.388 – 19, pp. 1767 – 1778. 11/05/2023. DOI: 10.1056/NEJMoa2212851
  • AB McGregor; DM Geynisman; M Burotto; C Suárez; MT Bourlon; PC Barata; S Gulati; S Huo; F Ejzykowicz; SI Blum; V Del Tejo; M Hamilton; JR May; EX Du; A Wu; P Kral; C Ivanescu; A Chin; KA Betts; CH Lee; TK Choueiri; D Cella; C Porta. Matching-adjusted Indirect Comparison of Nivolumab Plus Cabozantinib Versus Pembrolizumab Plus Axitinib in Patients with Advanced Renal Cell Carcinoma. Eur. Urol. Oncol.6 – 3, pp. 339 – 348. 01/06/2023. ISSN 2588-9311. DOI: 10.1016/j.euo.2023.01.012
  • Suárez C, Vieito M, Valdivia A, González M, Carles J. Med Sci (Basel). Selective HIF2A Inhibitors in the Management of Clear Cell Renal Cancer and Von Hippel-Lindau-Disease-Associated Tumors. 2023 Jun 30;11(3):46. doi: 10.3390/medsci11030046. PMID: 37489462 Free PMC article. Review.
  • Agarwal, N.; Azad, A. A.; Carles, J. Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial (vol 402, pg 291, 2023). LANCET. 402 – 10398, pp. 290 – 290. 22/07/2023. ISSN 0140-6736, ISSN 1474-547X
  • MS Ernst; V Navani; JC Wells; F Donskov; N Basappa; C Labaki; SK Pal; L Meza; LA Wood; DS Ernst; B Szabados; RR McKay; F Parnis; C Suarez; T Yuasa; AK Lalani; A Alva; GA Bjarnason; TK Choueiri; DYC Heng. Outcomes for International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Groups in Contemporary First-line Combination Therapies for Metastatic Renal Cell Carcinoma. Eur. Urol  2023; 84 (1): 109 – 116. 07/2023. DOI: 10.1016/j.eururo.2023.01.001
  • Gelderblom H, Jones RL, Blay JY, George S, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Siontis BL, Goldstein D, Boye K, Sanchez C, Steeghs N, Rutkowski P, Druta M, Serrano C, Somaiah N, Chi P, Harrow B, Becker C, Reichmann W, Sherman ML, Ruiz-Soto R, Heinrich MC, Bauer S; INTRIGUE investigators. Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study. Eur J Cancer. 2023 Oct;192:113245. doi:  10.1016/j.ejca.2023.113245. Epub 2023 Jul 20. PMID: 37598656 Free article. Clinical Trial.
  • SK Pal; L Albiges; P Tomczak; C Suárez; MH Voss; G de Velasco; J Chahoud; A Mochalova; G Procopio; H Mahammedi; F Zengerling; C Kim; T Osawa; M Angel; S Gupta; O Khan; G Bergthold; B Liu; M Kalaitzidou; M Huseni; C Scheffold; T Powles; TK Choueiri. Atezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomized, open-label, phase 3 trial. Lancet, 402, pp. 185 – 195. 15/07/2023. DOI: 10.1016/S0140-6736(23)00922-4.
  • Serrano C, Martín-Broto J, Asencio-Pascual JM, López-Guerrero JA, Rubió-Casadevall J, Bagué S, García-Del-Muro X, Fernández-Hernández JÁ, Herrero L, López-Pousa A, Poveda A, Martínez-Marín V. 2023 GEIS Guidelines for gastrointestinal stromal tumors.  Ther Adv Med Oncol. 2023 Aug 24;15:17588359231192388. doi: 10.1177/17588359231192388. eCollection 2023. PMID: 37655207 Free PMC article. Review.
  • Laurence Albiges; Howard Gurney; Vagif Atduev; Cristina Suarez; Miguel A Climent; David Pook; Piotr Tomczak; Philippe Barthelemy; Jae Lyun Lee; Viktor Stus; Thomas Ferguson; Erhan Gokmen; Louis Lacombe; Craig Gedye; Rodolfo F Perini; Manish Sharma; Xiang Peng; Lee Chung-Han. Pembrolizumab plus lenvatinib as first-line therapy for advanced nonclear-cell renal cell carcinoma (KEYNOTE-B61): a single-arm, multicentre, phase 2 trial. The Lancet. 24 – 8, pp. 881 – 891. 01/08/2023. DOI: 10.1016/S1470-2045(23)00276-0
  • Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF; INDIGO Trial Investigators. Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. N Engl J Med. 2023 Aug 17;389(7):589-601. doi: 10.1056/NEJMoa2304194. Epub 2023 Jun 4. PMID: 37272516 Clinical Trial.
  • Tabernero J, Bedard PL, Bang YJ, Vieito M, Ryu MH, Fagniez N, Chadjaa M, Soufflet C, Masson N, Gazzah A. Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens. Cancer Res Commun. 2023 Aug 28;3(8):1662-1671. doi: 10.1158/2767-9764.CRC-23-0284. eCollection 2023 Aug. PMID: 37645622 Free PMC article. Clinical Trial.
  • Di Vito A, Ravegnini G, Gorini F, Aasen T, Serrano C, Benuzzi E, Coschina E, Monesmith S, Morroni F, Angelini S, Hrelia P. The multifaceted landscape behind imatinib resistance in gastrointestinal stromal tumors (GISTs): A lesson from ripretinib. Pharmacol Ther. 2023  Aug; 248:108475. doi: 10.1016/j.pharmthera.2023.108475. Epub 2023 Jun 10.
  • Martin-Broto J, Valverde C, Hindi N, Vincenzi B, Martinez-Trufero J, Grignani G, Italiano A, Lavernia J, Vallejo A, Tos PD, Le Loarer F, Gonzalez-Campora R, Ramos R, Hernández-Jover D, Gutierrez A, Serrano C, Monteagudo M, Letón R, Robledo M, Moura DS, Martin-Ruiz M, López-Guerrero JA, Cruz J, Fernandez-Serra A, Blay JY, Fumagalli E, Martinez-Marin V. REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial. Mol Cancer. 2023 Aug 9;22(1):127.
  • Carreras, Maria-Josep; Tomas-Guillen, Elena; Farriols, Anna; Renedo-Miro, Berta; Valdivia, Carolina; Vidal, Jana; Saura, Cristina; Carles, Joan; Felip, Enriqueta; Gorgas, Maria-Queralt; Tabernero, Josep; Monterde, Josep. Use of Drugs in Clinical Practice and the Associated Cost of Cancer Treatment in Adult Patients with Solid Tumors: A 10-Year Retrospective Cohort Study. Curr Oncol. 30 – 9, pp. 7984 – 8004. MDPI, 01/09/2023. ISSN 1198-0052, ISSN 1718-7729
  • Pook, David; Geynisman, Daniel M.; Carles, Joan; de Braud, Filippo; Joshua, Anthony M.; Perez-Gracia, Jose Luis; Perez, Casilda Llacer; Shin, Sang Joon; Fang, Bruno; Barve, Minal; Maruzzo, Marco; Bracarda, Sergio; Kim, Miso; Kerloeguen, Yannick; Gallo, Jorge Daniel; Maund, Sophia L.; Harris, Adam; Huang, Kuan-Chieh; Poon, Victor; Sutaria, Dhruvitkumar S.; Gurney, Howard. A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer. Clin Can Res 2023; 29 – 17, AMER ASSOC CANCER RESEARCH, 01/09/2023. ISSN 1078-0432, ISSN 1557-3265
  • Serrano C, Álvarez R, Carrasco JA, Marquina G, Martínez-García J, Martínez-Marín V, Sala MÁ, Sebio A, Sevilla I, Martín-Broto J. SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022). Clin Transl Oncol. 2023 Sep;25(9):2707-2717. doi: 10.1007/s12094-023-03177-7. Epub 2023 May 2. PMID: 37129716 Free PMC article.
  • Giacomo Nuvola; Veronica Mollica; Francesco Massari; Cristina Suárez. SEP The future of immunotherapy in advanced renal cell carcinoma: beyond PD-1/PD-L1 inhibitors.  Future Medicine. 18/09/2023. DOI: 10.2217/imt-2023-021
  • Vieito M, Moreno V, Spreafico A, Brana I, Wang JS, Preis M, Hernández T, Genta S, Hansen AR, Doger B, Galvao V, Lenox L, Brown RJ, Kalota A, Mehta J, Pastore F, Patel B, Mistry P, Gu J, Lauring J, Patel MR. Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors.  Clin Cancer Res. 2023 Sep 15;29(18):3592-3602. doi: 10.1158/1078-0432.CCR-23-0092. PMID: 37491846 Clinical Trial.
  • Hernando-Calvo A, Vila-Casadesús M, Bareche Y, Gonzalez-Medina A, Abbas-Aghababazadeh F, Lo Giacco D, Martin A, Saavedra O, Brana I, Vieito M, Fasani R, Stagg J, Mancuso F, Haibe-Kains B, Han M, Berche R, Pugh TJ, Mirallas O, Jimenez J, Gonzalez NS, Valverde C, Muñoz-Couselo E, Suarez C, Diez M, Élez E, Capdevila J, Oaknin A, Saura C, Macarulla T, Carles Galceran J, Felip E, Dienstmann R, Bedard PL, Nuciforo P, Seoane J, Tabernero J, Garralda E, Vivancos A. A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials.  Med. 2023 Oct 13;4(10):710-727.e5. doi: 10.1016/j.medj.2023.07.006. Epub 2023 Aug 11. PMID: 37572657 Free article.
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  • Genetic counseling in prostate cancer How to implement it in daily clinical practice?. Borque-Fernando A, Espilez R, Miramar D, Corbaton D, Rodriguez A, Castro E, Mateo J, Rello L, Mendez A, Gil Sanz M. J. Actas Urol Españolas. 2021 Jan; 45 (1): 8-20.
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  • Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer. Gonzalez A, Mateo J, Stenzinger A, Rojo F, Shiller M, Alexander W, Penault-Llorca F, Gomella LG, Eeles R, Bjartell A. J Pathol Clin Res. 2021 Jul; 7 (4): 311 – 325.
  • Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer. Casanova-Salas I, Athie A, Boutros PC, Del Re M, Miyamoto DT, Pienta   KJ, Posadas EM, Sowalsky AG, Stenzl A, Wyatt AW, Mateo J. Eur Urol. 2021 79 (6): 762 – 771.
  • Ripretinib and MEK inhibitors synergize to induce apoptosis in preclinical models of GIST and systemic mastocytosis. Gupta A, Singh J, García-Valverde A, Serrano C, Flynn DL Smith BD. Mol Cancer Ther. 2021 Jul; 20 (7): 1234 – 1245.
  • Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA. Sumanasuriya Semini, Seed G, Parr H, Christova R, Pope L, Bertan C, Bianchini D, Rescigno P, Figueiredo I, Goodall J, Fowler G, Flohr P; Mehra N, Neeb A, Rekowski J, Eisenberger M, Sartor O, Oudard S, Geffriaud-Ricouard C, Ozatilgan A, Chadjaa M, Mace S, Lord C, Baxter J, Pettitt S, Lambros M, Sharp A, Mateo J, Carreira S, Yuan W, de Bono JS. Eur Urol. 2021 Aug; 80 (2): 243 – 253.
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  • SEOM Clinical Guideline of management of soft-tissue sarcoma (2016). López-Pousa A, Martin Broto J, Martinez Trufero J, Sevilla I, Valverde C, Alvarez R, Carrasco Alvarez JA, Cruz Jurado J, Hindi N, Garcia Del Muro X.  Clin Transl Oncol. 2016 Dec;18(12):1213-1220.
  • Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Srinivas S, Morales-Barrera R, Carles J, Al-Wardat R, Al-Rabi K, Maakoseh M.  Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model. Clin Genitourin Cancer 2016 Jun; 14(3): 255-60
  • Serrano C, Romagosa C, Hernandez-Losa J, Simonetti S, Valverde C, Moliné T, Somoza R, Pérez M, Vélez R, Verges R, Domínguez R, Carles J, Ramón y Cajal S.  RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas. Cancer 2016 Jan; 122(1): 99-107
  • Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE.  Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015 Feb; 16(2): 152-60
  • De Mattos-Arruda L, Mayor R, Ng CK, Weigelt B, Martínez-Ricarte F, Torrejón D, Oliveira M, Arias A, Raventós C, Tang J, Guerini-Rocco E, Martínez-Sáez E, Lois S, Marín O, de la Cruz X, Piscuoglio S, Towers R, Vivancos A, Peg V, Ramón y Cajal S, Carles J, Rodón J, González-Cao M, Tabernero J, Felip E, Sahuquillo J, Berger MF, Cortes J, Reis-Filho JS, Seoane J.  Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat Commun 2015; 6: 8839
  • Smith MR, Rathkopf DE, Mulders PF, Carles J, Van Poppel H, Li J, Kheoh T, Griffin TW, Molina A, Ryan CJ.  Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. J. Urol. 2015 Nov; 194(5): 1277-84
  • Suárez C, Morales-Barrera R, Ramos V, Nuñez I, Valverde C, Planas J, Morote J, Maldonado X, Carles J.  Role of immunotherapy in castration-resistant prostate cancer (CRPC). BJU Int. 2014 Mar; 113(3): 367-75
  • Morales-Barrera R, Suárez C, Valverde C, Nuñez I, Maldonado X, Morote J, Carles J.  Do patients with metastatic urothelial carcinoma benefit from docetaxel as second-line chemotherapy? Clin Transl Oncol 2014 Jan; 16(1): 102-6
  • Simonetti S, Serrano C, Hernandez-Losa J, Bagué S, Orellana R, Valverde C, Lleonart ME, Aizpurua M, Carles J, Ramón y Cajal S, Romagosa C.  Schwannomas, benign tumors with a senescent phenotype.Histol. Histopathol. 2014 Jun; 29(6): 721-30
  • Prior C, Pérez-Gracia JL, García-Donas J, Rodriguez-Antona C, Guruceaga E, Esteban E, Suárez C, Castellano D, del Alba AG, Lozano MD, Carles J, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Gurpide A, Lopez-Picazo JM, Hernandez AG, Mellado B, Martínez E, Moreno F, Font A, Calvo A.  Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS ONE 2014; 9(1): e86263
  • Castellano DE, Bellmunt J, Maroto JP, Font-Pous A, Morales-Barrera R, Ghanem I, Suárez C, Martín Lorente C, Etxaniz O, Capdevila L, Coronado C, Alfaro V, Siguero M, Fernández-Teruel C, Carles J. Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen. Cancer Chemother. Pharmacol. 2014 Apr; 73(4): 857-67
  • Rathkopf DE, Smith MR, de Bono JS, Logothetis CJ, Shore ND, de Souza P, Fizazi K, Mulders PF, Mainwaring P, Hainsworth JD, Beer TM, North S, Fradet Y, Van Poppel H, Carles J, Flaig TW, Efstathiou E, Yu EY, Higano CS, Taplin ME, Griffin TW, Todd MB, Yu MK, Park YC, Kheoh T, Small EJ, Scher HI, Molina A, Ryan CJ, Saad F.  Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302). Eur. Urol. 2014 Nov; 66(5): 815-25
  • Foro P, Algara M, Lozano J, Rodriguez N, Sanz X, Torres E, Carles J, Reig A, Membrive I, Quera J, Fernandez-Velilla E, Pera O, Lacruz M, Bellosillo B.  Relationship between radiation-induced apoptosis of T lymphocytes and chronic toxicity in patients with prostate cancer treated by radiation therapy: a prospective study. Int. J. Radiat. Oncol. Biol. Phys. 2014 Apr; 88(5): 1057-63
  • Morote J, Planas J, Maldonado X, Carles J.  Non-metastatic castration-resistant prostate cancer (CPRCM0), an old scenario with renewed clinical interest. Actas Urol Esp 2014 Sep; 38(7): 419-20
  • Bellmunt J, Suárez C, Gallardo E, Rodón J, Pons F, Bonfill T, Beltran M, Moya I, Galtes S, Albanell J, Carles J.  Phase I study of sunitinib in combination with gemcitabine and capecitabine for first-line treatment of metastatic or unresectable renal cell carcinoma. Oncologist 2014 Sep; 19(9): 917-8
  • Morote J, Celma A, Planas J, Placer J, de Torres I, Olivan M, Carles J, Reventos J, Doll A.  Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness. Int J Mol Sci 2014; 15(8): 13615-23
  • Serrano C, Simonetti S, Hernandez-Losa J, Valverde C, Carrato C, Bagué S, Orellana R, Somoza R, Moliné T, Carles J, Huguet P, Romagosa C, Ramón y Cajal S.  BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumours. Histopathology 2013 Feb; 62(3): 499-504
  • Morote J, Ropero J, Planas J, Bastarós JM, Delgado G, Placer J, Celma A, de Torres IM, Carles J, Reventos J, Doll A.  Metabolic syndrome increases the risk of aggressive prostate cancer detection. BJU Int. 2013 Jun; 111(7): 1031-6
  • Mesia R, Rueda A, Vera R, Lozano A, Medina JA, Aguiar D, Árias F, Triana G, Carles J, Lopez-Lopez R.  Adjuvant therapy with cetuximab for locally advanced squamous cell carcinoma of the oropharynx: results from a randomized, phase II prospective trial. Ann. Oncol. 2013 Feb; 24(2): 448-53
  • Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE.  Abiraterone in metastatic prostate cancer without previous chemotherapy. N. Engl. J. Med. 2013 Jan; 368(2): 138-48
  • de la Piedra C, Alcaraz A, Bellmunt J, Meseguer C, Gómez-Caamano A, Ribal MJ, Vazquez F, Anido U, Samper P, Esteban E, Álvarez-Ossorio JL, Lara PC, San José LA, Contreras JA, del Alba AG, González-Gragera B, Tabernero AJ, González-Enguita C, Fernández JM, García-Escudero A, Gómez-Veiga F, Méndez MJ, Segarra J, Virizuela JA, Carles J, Lassa A, Calderero V, Constela M, Delgado D, Mañas A, Murias A, Reynes G, Rodriguez B, Rubio G, Sánchez E, Unda M, Solsona E, Martínez-Javaloyas JM, Comet-Batlle J, Quicios C, Martín-Fernández M, Mahillo-Fernández I, Morote J. Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study. Br. J. Cancer 2013 Jun; 108(12): 2565-72
  • Alcaraz A, González-López R, Morote J, de la Piedra C, Meseguer C, Esteban E, Climent M, González-Gragera B, Álvarez-Ossorio JL, Chirivella I, Mellado B, Lara PC, Vazquez F, Contreras JA, Carles J, Murias A, Calderero V, Comet-Batlle J, González-Del Alba A, León-Mateos L, Mañas A, Segarra J, Lassa A, González-Enguita C, Méndez MJ, Samper P, Unda M, Mahillo-Fernández I, Bellmunt J.  Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study.Br. J. Cancer 2013 Jul; 109(1): 121-30
  • Serrano C, Morales R, Suárez C, Nuñez I, Valverde C, Rodón J, Humbert J, Padrós O, Carles J. Emerging therapies for urothelial cancer. Cancer Treat. Rev. 2012 Jun; 38(4): 311-7
  • Castellano D, Carles J, Esteban E, Trigo JM, Climent MA, Maroto JP, del Muro XG, Font A, Paz-Ares L, Arranz JA, Bellmunt J.  Recommendations for the optimal management of early and advanced urothelial carcinoma. Cancer Treat. Rev. 2012 Aug; 38(5): 431-41
  • Carles J, Castellano D, Climent MA, Maroto P, Medina R, Alcaraz A.  Castration-resistant metastatic prostate cancer: current status and treatment possibilities. Clin Transl Oncol 2012 Mar; 14(3): 169-76
  • Carles J, Chirivella I, Climent MA, Gallardo E, Gonzalez Del Alba A, Maroto JP, Mellado B, García del Muro FX.  Evaluation of patients with metastatic renal cell carcinoma after failure of first-line treatment. Cancer Metastasis Rev. 2012 Sep; 31 Suppl 1: S3-9
  • Morales-Barrera R, Bellmunt J, Suárez C, Valverde C, Guix M, Serrano C, Gallen M, Carles J.  Cisplatin and gemcitabine administered every two weeks in patients with locally advanced or metastatic urothelial carcinoma and impaired renal function. Eur. J. Cancer 2012 Aug; 48(12): 1816-21
  • Cózar JM, Solsona E, Morote J, Miñana B, Maroto JP, Gonzalez Del Alba A, Climent MA, Carles J, Alcaraz A, Castellano D.  [Recomendations on the management of controversies in advanced castrate-resistant prostate cancer]. Actas Urol Esp 2012; 36(10): 569-77
  • Alcaraz A, Medina R, Maroto P, Climent MA, Castellano D, Carles J.  [Castration-resistant prostate cancer: where are we going?]. Actas Urol Esp 2012 Jun; 36(6): 367-74
  • Morales R, Font A, Carles J, Isla D.  SEOM clinical guidelines for the treatment of invasive bladder cancer. Clin Transl Oncol 2011 Aug; 13(8): 552-9
  • Bellmunt J, González-Larriba JL, Prior C, Maroto P, Carles J, Castellano D, Mellado B, Gallardo E, Pérez-Gracia JL, Aguilar G, Villanueva X, Albanell J, Calvo A.  Phase II study of sunitinib as first-line treatment of urothelial cancer patients ineligible to receive cisplatin-based chemotherapy: baseline interleukin-8 and tumor contrast enhancement as potential predictive factors of activity. Ann. Oncol. 2011 Dec; 22(12): 2646-53
  • Morales-Barrera R, Valverde C, Rodón J, Pérez J, Maldonado X, Suárez C, Trilla E, Carles J.  Bilateral testicular germ cell tumours: a single hospital experience. Clin Transl Oncol 2010 Apr; 12(4): 299-302
  • Carles J, Nogué M, Sole JM, Foro P, Domènech M, Suarez M, Gallardo E, García D, Ferrer F, Gelabert-Mas A, Gayo J, Fabregat X.  Phase II study of vinorelbine and estramustine in combination with conformational radiotherapy for patients with high-risk prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 2010 Mar; 76(4): 1085-91
  • Serrano C, Suárez C, Andreu J, Carles J.  Acute aortic dissection during sorafenib-containing therapy.Ann. Oncol. 2010 Jan; 21(1): 181-2
  • Pérez-García J, Morales R, Valverde CM, Rodón J, Suárez C, Semidey ME, Garcia-Patos V, Bartralot R, Serra M, Carles J.  Eccrine porocarcinoma presenting with scrotal lymphedema: a case report and review of systemic treatment. Ann. Oncol. 2010 Apr; 21(4): 907
  • Bellmunt J, Maroto-Rey P, Trigo JM, Carles J, Guillem V, López-Martín JA, Antón-Torres A, Urruticoechea L.  A phase II trial of first-line sorafenib in patients with metastatic renal cell carcinoma unwilling to receive or with early intolerance to immunotherapy: SOGUG Study 06-01. Clin Transl Oncol 2010 Jul; 12(7): 503-8
  • Suárez C, Morales R, Muñoz E, Rodón J, Valverde CM, Carles J.  Molecular basis for the treatment of renal cell carcinoma. Clin Transl Oncol 2010 Jan; 12(1): 15-21
  • Bellmunt J, Trigo JM, Calvo E, Carles J, Pérez-Gracia JL, Rubió J, Virizuela JA, López R, Lázaro M, Albanell J.  Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06). Lancet Oncol. 2010 Apr; 11(4): 350-7
  • Carles J, Morales R, Perez JM, Suárez C, Rodón J, Valverde C.  Management and interpretation of novel toxicities of molecular targeted therapies: renal toxicities. Eur. J. Cancer 2009 Sep; 45 Suppl 1: 309-17
  • Bellmunt J, Théodore C, Demkov T, Komyakov B, Sengelov L, Daugaard G, Caty A, Carles J, Jagiello-Gruszfeld A, Karyakin O, Delgado FM, Hurteloup P, Winquist E, Morsli N, Salhi Y, Culine S, von der Maase H.  Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J. Clin. Oncol. 2009 Sep; 27(27): 4454-61
  • Bellmunt J, Macià F, Malmusi D, Llorente JA, Carles J, Lloreta J, Foro P, Gelabert A, Albanell J, Castells X.  Impact of PSA implementation and combined radiation and hormonal therapy (RT+HT) on outcome of prostate cancer patients. Eur. J. Cancer 2009 Nov; 45(16): 2804-9
  • Bellmunt J, Carles J, Albanell J.  Predictive modelling in hormone-refractory prostate cancer (HRPC). Clin Transl Oncol 2009 Feb; 11(2): 82-5
  • Martínez P, Valverde C, Morales R, Rodón J, Suárez C, Baselga J, Carles J.  Docetaxel activity in second line treatment for urothelial carcinoma: a retrospective analysis European Journal of Cancer Supplements 2009 September; 7(2): 448
  • Carles J, Font A, Mellado B, Domènech M, Gallardo E, González-Larriba JL, Catalan G, Alfaro J, Gonzalez Del Alba A, Nogué M, Lianes P, Tello JM.  Weekly administration of docetaxel in combination with estramustine and celecoxib in patients with advanced hormone-refractory prostate cancer: final results from a phase II study. Br. J. Cancer 2007 Nov; 97(9): 1206-10
  • Carles J, Esteban E, Climent M, Font A, González-Larriba JL, Berrocal A, Garcia-Ribas I, Marfa X, Fabregat X, Albanell J, Bellmunt J.  Gemcitabine and oxaliplatin combination: a multicenter phase II trial in unfit patients with locally advanced or metastatic urothelial cancer. Ann. Oncol. 2007 Aug; 18(8): 1359-62
  1. Gene mutation profiling of patients with Metastatic renal cell carcinoma treated with mTOR. inhibitors PI: Joan Carles Funding: FERO From 01/10/2015 to 31/12/2023
  2. Defining the Landscape and Clinical Relevance of ATM Defects in Lethal Prostate Cancer. IP: Joaquín Mateo Funding: Prostate Cancer Foundation From 21/11/2017 to 31/12/2023
  3. Base de datos europea de inmunoterapia en cáncer vesical​. PI: Rafael Morales. Entity:  Barts Cancer Centre 2017
  4. Caracterización del potencial predictivo y terapéutico del FBXO32 como mediador crítico de la señalización oncogénica de KIT/PDGFRA en tumores del estroma gastrointestinal. PI: César Serrano Funding: FMPJC From 18/12/2017 to 31/12/2023
  5. Estudio de los determinantes bioloógicos responsables de respuesta prolongada (>5 años) a la inhibición de KIT en tumores del estroma gastrointestinal (GIST). PI: Cesar Serrano Funding: SEOM From 12/02/2018 to 31/12/2023
  6. Caracterización del impacto funcional de mutaciones en genes de la reparación del DNA en pacientes con cáncer de próstata. PI: Joaquín Mateo Funding: SEOM From 12/02/2018 to 31/12/2023
  7. Analisis mutacional de los pacientes de todos los centros participantes en el estudio GEIS 36 (COSYMO). Detección de mutación PIK3CA y PTEN en liposarcomas mixoides. PI: Joan Carles Entity: COSYMO (GEIS 36) From 21/02/2018 to 31/12/2023
  8. W81XWH1810758/Clinical Qualification of DNA Repair Defects as Biomarkers in Metastatic Prostate Cancer Using Integrated Genomics and Tissue-Based Functional Assays. PI: Joaquín Mateo Funding: DoD From 30/09/2018 to 30/09/2023
  9. Perfiles moleculares de cáncer de próstata asociados a defectos de la reparación del ADN para el desarrollo de estrategias de medicina personalizada. PI: Joaquín Mateo Funding: FIS From 01/01/2019 to 30/06/2022
  10. Co-targeting androgen receptor signalling and DNA damage repair for precision therapy. PI: Joaquín Mateo Funding: H2020-MSCA-IF-2018 From 01/05/2019 to 21/07/2021
  11. IRONMAN-ES: Estudio prospectivo observacional de parámetros clinicos y biomarcadores en cáncer de próstata avanzado en hospitales de España. PI: Joaquín Mateo Funding: IRONMAN From 15/05/2019 to  31/12/2023
  12. Novel approaches to liquid biopsy in prostate cancer to inform precision medicine. PI: Joaquín Mateo Funding: FERO From 01/07/2019 to 31/12/2022
  13. Start-up César Serrano – Estudio de los mecanismos de resistencia a la terapia personalizada (inhibidores KIT/PDGFRA) en tumores gastrointestinales de estroma (GIST). PI: Cesar Serrano Funding: FERO From 01/01/2020 to 31/12/2022
  14. Expresión de pd-l1, infiltración linfocitario  antes y después del tratamiento de quimioterapia neoadyuvante en el carcinoma urotelial y la relación con los diferentes subtipos moleculares de carcinoma urotelial. PI: Rafael Morales Entity: VHIO From: 2020 to 2023
  15. Avaluant l’efectivitat de teràpies de precisió dirigides a alteracions genètiques recurrents en Tumors Malignes de la Beina del Nervi Perifèric. PI: Joan Carles Funding: MARATÓ From 01/07/2020 to 30/06/2023
  16. DIVAS-Dissecting VAsculas Sarcomas. PI: Cesar Serrano Funding: GEIS From 02/11/2020 to 31/12/2023
  17. Estudio de la interacción entre las vías de señalización de andrógenos y reparación del ADN en cáncer de próstata metastásico y tratamiento con combinaciones con inhibidores de PARP. PI: Joaquín Mateo Funding: AECC From 01/12/2020 to 30/11/2023
  18. Becas de Posdoctorado Junior Leader La Caixa – Integrated analysis of blood circulating tumor signatures to monitor genomic evolution and therapy responses in advanced Prostate Cancer. PI: Joaquín Mateo Funding: LA CAIXA From 01/12/2020 to 22/04/2024
  19. Perfiles de resistencia molecular a la inhibición de KIT/PDGFRA en tumores del estroma gastrointestinal. PI: Cesar Serrano Funding: AECC From 01/12/2020 to 30/11/2024
  20. TCGA de tumores de origen desconocido. PI: Rafael Morales Entity: National Cancer Institute, National Human Genome Research Institute From: 2020 to 2024
  21. Exploitng therapy-induced senescence in a synthetic lethal approach to treat advanced Prostate Cancer. PI: Joaquín Mateo Funding: FERO From 01/05/2021 to 30/04/2023
  22. RELAGERM: recaidas tardias de tumores germinales. PI: Rafael Morales Entity: Istituto Oncologico della Svizzera Italiana From: 2021 to 2023
  23. Características y resultados de los pacientes con diagnóstico de carcinoma urotelial metastásico que desarrollan toxicidad inmunomediada relacionada con el tratamiento de inmunoterapia sistémica. PI: Rafael Morales Entity: VHIO From: 2021 to 2024
  24. Prostate Cancer genomic evolution and signatures of DNA damage repair deficiencies. PI: Joaquín Mateo Grantor: CRIS Cancer Foundation From 01/09/2021 to 01/09/2026
  25. Tumoral senescence induced by anti-cancer therapies constitutes a novel prognostic biomarker and a therapeutic target IP: Joaquín Mateo Funding: AECC From 01/10/2021 to 30/09/2026
  26. Modulating our ubiquitination machinery to innovate treatments and drug discovery in cancer. PI: Cesar Serrano Funding: AECC From 01/12/2021 to 30/11/2024
  27. Impacto de la quimioterapia neoadyuvante en pacientes con variantes histológicas en el carcinoma urotelial de vejiga. PI: Rafael Morales Funding: SOGUG From: 2022 to 2024
  28. Start-Up: Estudio de los mecanismos de resistencia a la terapia personalizada (inhibidores KIT/PDGFRA) en tumores gastrointestinales de estroma (GIST). PI: Cesar Serrano Funding: FERO From 01/01/2022 to 31/12/2023
  29. Traslación a la clínica de una nueva terapia dirigida para el tratamiento del sarcoma de ewing. PI: Cesar Serrano Funding: RETOS From 01/03/2022 to 28/02/2025
  30. Multi-analyte liquid biopsy to monitor tumor genomic evolution and therapy response in advanced Prostate Cancer. PI: Joaquín Mateo Funding: H2020-MSCA-IF-2020 From 28/03/2022 to 28/03/2024
  31. Multimodal Biomarkers for Precise Management of Metastatic Prostate Cancer. MARION. PI: Joaquín Mateo Funding: RETOS From 01/09/2022 to 31/08/2025
  32. Translational research and innovation programme clinics. PI: Cesar Serrano Entity: IRB From 01/11/2022 to 31/12/2024
  33. Real world clinical practice study to assess the feasibility and impact of liquid biopsy-based genomic profiling on treatment decision making for patients with metastatic prostate cancer in Spain. PIs: Joaquín Mateo and Joan Carles Funding: SOLTI From 24/11/2022 to 31/12/2024
  34. Targeted kinase inhibition and immune response in gastrointestional stromalm – GEIS. PI: Cesar Serrano Funding: FMPJC GEIS From 31/12/2022 to 31/12/2025

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