Biosketch

Mate Maus

matemaus@vhio.net

Posició actual

Cap del Grup d’Envelliment i Càncer

Formació acadèmica

Doctorat en Immunologia, Universitat Eötvös Loránd, Hongria, 2010
Grau en Ciències de la Vida, Universitat Eötvös Loránd, Hongria, 2006

Àrees d'investigació

Envelliment del microentorn i càncer
Immunosenescència i càncer
Detecció de nutrients en la senescència cel·lular en l’envelliment i el càncer

Premis i beques

2022 – 2027 Beca Ramón y Cajal,Investigador principal: Mate Maus; afiliació: IRB Barcelona; dotació econòmica: 219 250 €

Publicacions

Maus M, López-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, Meyer K, Sola A, Lopez-Martinez C, López-Alonso I, Guasch-Piqueras M, Hernandez-Gonzalez F, Chaib S, Rovira M, Sanchez M, Faner R, Agusti A, Diéguez-Hurtado R, Ortega S, Manonelles A, Engelhardt S, Monteiro F, Stephan-Otto Attolini C, Prats N, Albaiceta G, Cruzado JM, Serrano M. Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype. Nat Metab. 2023 Dec;5(12):2111-2130.
Maus M, López-Polo V, Lafarga M, Aguilera M, De Lama E, Meyer K, Manonelles A, Sola A, López Martínez C, López-Alonso I, Hernández-Gonzales F, Chaib S, Rovira M, Sánchez M, Faner R, Agusti A, Prats N, Albaiceta G, Cruzado JM, Serrano M. Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype. bioRxiv 2022 https://doi.org/10.1101/2022.07.29.501953
Rovira M, […], Maus M, […], Serrano M. (2022) The lysosomal proteome of senescent cells contributes to the senescence secretome. Aging Cell. 2022 Oct;21(10):e13707
Maus M, Serrano M. A novel redox cycle diverts cells from oncogene-induced senescence into cancer. Mol Cell. 16 sept. 2021;81(18):3672-3674.
Kahlfuss S, Kaufmann U, Concepción AR, Noyer L, Raphael D, Vaeth M, Yang J, Pancholi P, Maus M, Muller J, Kozhaya L, Khodadadi-Jamayran A, Sun Z, Shaw P, Unutmaz D, Stathopulos PB, Feist C, Cameron SB, Turvey SE, Feske S. STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. EMBO Mol Med. 7 ago. 2020;12(8):e11592.
Saint Fleur-Lominy S* y Maus M*, Vaeth M, Lange I, Zee I, Suh D, Liu C, Wu X, Tikhonova A, Aifantis I, Feske S. STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep. 11 sept. 2018;24(11):3045-3060.e5. (*contribución por igual)
Vaeth M* y Maus M*, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, Cameron S, Turvey SE, Serfling E, Berberich-Siebelt F, Possemato R, Feske S. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity. 17 oct. 2017;47(4):664-679.e6. (*contribución por igual)
Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do HT, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. Cell Metab. 7 mar. 2017;25(3):698-712.
Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol. 1 ago. 2015;195(3):1202-17.
Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S. Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation. Proc Natl Acad Sci U S A. 12 may. 2015;112(19):6206-11.
Maus M, Medgyesi D, Kiss E, Schneider AE, Enyedi A, Szilágyi N, Matkó J, Sármay G. B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes. J Leukoc Biol. 2013;93(4):537-47.
Maus M, Medgyesi D, Kövesdi D, Csuka D, Koncz G, Sármay G. Grb2 associated binder 2 couples B-cell receptor to cell survival. Cell Signal. Feb 2009;21(2):220-7.
Sármay G, Angyal A, Kertész A, Maus M, Medgyesi D. The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol Lett. 15 abr. 2006;104(1-2):76-82.