Marta Crespo
macrespo@vhio.net
Lloc actual
Investigadora senior. Coordinadora d’Investigació Translacional Grup d’Hematologia Experimental, VHIO
Llocs anteriors
- 2001-2007 Estudiant de doctorat al laboratori d’Hematologia Experimental, Hospital Clínic, Barcelona
- 2007-2010 Investigadora postdoctoral, Institut de Genètica del Càncer, Universitat de Columbia, Nova York
- 2010-2016 Investigadora titular, laboratori d’Hematologia Experimental, Vall d’Hebron Institut de Recerca, Barcelona
Formació acadèmica
- 2013 Investigadora Ramón y Cajal
- 2006 Doctorada en Biopatologia en Medicina per la Universitat de Barcelona
- 2001 Llicenciada en Biologia per la Universitat de Barcelona
Àrees de recerca
- Mecanismes de progressió i patogènesi en les neoplàsies limfoides
- Estudi preclínic d’opcions terapèutiques en models que imiten el microambient immunitari tumoral (centrat en l’SNC)
- Biomarcadors per a un tractament racional i precís dels pacients
Premis i beques
- Beca de formació permanent Ramón y Cajal (2013)
- Beca postdoctoral MEC-Fulbright (2007)
- Premi als èxits dels resums de la Societat Americana d’Hematologia (2016)
- Premi Extraordinari de Tesi (2007)
Projectes
- AECC-2018 Macrophage mediated immunotherapy optimization in lymphomas affecting the central nervous system.
- ISCIII-2018 Role of immune surveillance and evasion in the physiopathology and immunotherapy in central nervous system lymphomas.
- AECC-2016- Targeted therapy for acute myeloid leukemia: ex vivo testing under conditions mimicking the bone marrow microenvironment.
- ISCIII-2014- New therapeutic options for primary central nervous system lymphoma: targeting deregulated signaling pathways using in vivo models.
Publicacions científiques més rellevants
- Isabel Jiménez; Júlia Carabia; Sabela Bobillo; Carles Palacio; Pau Abrisqueta; Carlota Pagès; Juan C. Nieto; Josep Castellví; Francisco Martínez-Ricarte; Lourdes Escoda; Cristóbal Perla; Dennis H. Céspedes Torrez; Joan Boix; Noelia Purroy; Lluís Puigdefàbregas; Joan Seoane; Francesc Bosch; Marta Crespo. Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.Journal of Neuro-Oncology. 20/07/2020.
- Marta Crespo; Sabela Bobillo; Laura Escudero; Regina Mayor; Priyanka Raheja; Cecilia del Carmen Carpio; Carlota Rubio-Pérez; Bárbara Tazón-Vega; Carles Palacio; Júlia Carabia; Isabel Jiménez; Juana C. Nieto; Júlia Montoro; Francisco Martínez-Ricarte; Josep Castellví; Marc Simó; Lluís Puigdefàbregas; Pau Abrisqueta; Joan Seoane; Francesc Bosch. Cell Free Circulating Tumor DNA in Cerebrospinal Fluid detects and monitors Central Nervous System Involvement of B-Cell Lymphomas. Haematologica. 20/02/2020.
- Júlia Carabia; Cecilia Carpio; Pau Abrisqueta; Isabel Jiménez; Noelia Purroy; Eva Calpe; Carles Palacio; Francesc Bosch; Marta Crespo. Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia. Scientific Reports. 25/09/2017.
- Noelia Purroy; Pau Abrisqueta; Júlia Carabia; Cecilia Carpio; Eva Calpe; Carles Palacio; Josep Castellví; Francesc Bosch; Marta Crespo. Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein.Leukemia. pp. 1993 – 2004. 01/10/2014.
- E Calpe; C Codony; MJ Baptista; P Abrisqueta; C Carpio; N Purroy; F Bosch; M Crespo. ZAP-70 enhances migration of malignant B lymphocytes toward CCL21 by inducing CCR7 expression via IgM-ERK1/2 activation. 118 – 16, pp. 4401 – 4410. 2011.
- Marta Crespo; Neus Villamor; Eva Giné; Ana Muntañola; Dolors Colomer; Teresa Marafioti; Margaret Jones; Mireia Camós; Elias Campo; Emili Montserrat; Francesc Bosch. ZAP-70 expression in normal pro/pre B-cells, mature B-cells, and in B-cell acute lymphoblastic leukaemia. Clinical Cancer Research. 12 – 3, pp. 726 – 734. 2006.
- Marta Crespo; Francesc Bosch; Neus Villamor; Beatriz Bellosillo; Dolors Colomer; Maruja Rozman; Armando López-Guillermo; Elias Campo; Emili Montserrat. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. New England Journal of Medicine. 348- 18, pp. 1764 – 1775. 2003.
